{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nVPS4B is an AAA ATPase that plays a central role in the endosomal sorting complex required for transport (ESCRT) pathway by recognizing and disassembling ESCRT‐III assemblies at membranes. Structural and biochemical studies reveal that its amino‐terminal microtubule interacting and trafficking (MIT) domain adopts a three‐helix bundle capable of binding conserved motifs in ESCRT‐III subunits (such as CHMP proteins) in a noncanonical orientation. Crystallographic analyses and solution studies have shown that VPS4B exists as monomers or dimers that, upon ATP binding, oligomerize into ring‐like structures to exert their remodeling functions, with its conformational domain rotations being key to substrate engagement and disassembly of ESCRT complexes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its structural attributes, VPS4B is indispensable for multiple membrane remodeling events. It regulates terminal membrane fission required for cytokinetic abscission and the proper maintenance of spindle poles and centrosomes during cell division, while also impacting the budding of enveloped viruses by recycling ESCRT components at sites of membrane scission. Studies in different viral systems demonstrate that while VPS4B function is essential for processes such as hepatitis B virus release and real‐time HIV-1 budding dynamics, it appears dispensable in influenza virus particle release. Importantly, regulatory inputs such as phosphorylation by CK2α and interactions with negative regulators like CHMP5 modulate VPS4B’s activity during these dynamic events."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "15"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDysregulation of VPS4B has been implicated in diverse pathophysiological contexts. In tumor cells, aberrant levels or activity of VPS4B contribute to altered receptor trafficking and growth signaling—for example, by affecting EGFR accumulation under hypoxic conditions—and synthetic lethal studies have identified VPS4B (and its paralog VPS4A) as crucial dependencies in cancers exhibiting chromosomal losses. Moreover, VPS4B modulates cell fate decisions in multiple settings: its dysregulation promotes pro-apoptotic signaling in intestinal epithelial cells associated with Crohn’s disease and in chondrocytes linked to osteoarthritis, while loss-of-function mutations impair the differentiation of dental pulp stem cells and underlie the pathogenesis of dentin dysplasia type I. Additionally, emerging evidence points to roles for VPS4B in virus-host interactions and even in modulating extracellular vesicle profiles in vascular malformations, underscoring its broad impact on cellular and tissue homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "26"}]}, {"type": "t", "text": ""}]}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Keiichi Katoh, Hidenori Suzuki, Yoshinori Terasawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The penta-EF-hand protein ALG-2 interacts directly with the ESCRT-I component TSG101, and Ca2+-dependently co-localizes to aberrant endosomes with dominant-negative AAA ATPase SKD1/Vps4B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20050398"}], "href": "https://doi.org/10.1042/BJ20050398"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16004603"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16004603"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hirotoshi Takasu, Jun Goo Jee, Ayako Ohno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural characterization of the MIT domain from human Vps4b."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2005.06.110"}], "href": "https://doi.org/10.1016/j.bbrc.2005.06.110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16018968"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16018968"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Anna Scott, Hyo-Young Chung, Malgorzata Gonciarz-Swiatek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural and mechanistic studies of VPS4 proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7600818"}], "href": "https://doi.org/10.1038/sj.emboj.7600818"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16193069"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16193069"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Melissa D Stuchell-Brereton, Jack J Skalicky, Collin Kieffer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ESCRT-III recognition by VPS4 ATPases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature06172"}], "href": "https://doi.org/10.1038/nature06172"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17928862"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17928862"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Michio Inoue, Hironari Kamikubo, Mikio Kataoka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nucleotide-dependent conformational changes and assembly of the AAA ATPase SKD1/VPS4B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Traffic (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0854.2008.00831.x"}], "href": "https://doi.org/10.1111/j.1600-0854.2008.00831.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18796009"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18796009"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Sonja Welsch, Anja Habermann, Stefanie Jäger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ultrastructural analysis of ESCRT proteins suggests a role for endosome-associated tubular-vesicular membranes in ESCRT function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Traffic (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0854.2006.00489.x"}], "href": "https://doi.org/10.1111/j.1600-0854.2006.00489.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17014699"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17014699"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Carsten Lambert, Tatjana Döring, Reinhild Prange "}, {"type": "b", "children": [{"type": "t", "text": "Hepatitis B virus maturation is sensitive to functional inhibition of ESCRT-III, Vps4, and gamma 2-adaptin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00479-07"}], "href": "https://doi.org/10.1128/JVI.00479-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17553870"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17553870"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Shuzo Urata, Hideyoshi Yokosawa, Jiro Yasuda "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of HTLV-1 Gag budding by Vps4A, Vps4B, and AIP1/Alix."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virol J (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1743-422X-4-66"}], "href": "https://doi.org/10.1186/1743-422X-4-66"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17601348"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17601348"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Emily A Bruce, Liz Medcalf, Colin M Crump, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Budding of filamentous and non-filamentous influenza A virus occurs via a VPS4 and VPS28-independent pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virology (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.virol.2009.05.016"}], "href": "https://doi.org/10.1016/j.virol.2009.05.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19524996"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19524996"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Eiji Morita, Leremy A Colf, Mary Anne Karren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1005938107"}], "href": "https://doi.org/10.1073/pnas.1005938107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20616062"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20616062"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Rie Watanabe, Robert A Lamb "}, {"type": "b", "children": [{"type": "t", "text": "Influenza virus budding does not require a functional AAA+ ATPase, VPS4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virus Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.virusres.2010.07.006"}], "href": "https://doi.org/10.1016/j.virusres.2010.07.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20621136"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20621136"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Mauro Salvi, Camilla Raiborg, Phyllis I Hanson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CK2 involvement in ESCRT-III complex phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Biochem Biophys (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.abb.2014.01.006"}], "href": "https://doi.org/10.1016/j.abb.2014.01.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24440309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24440309"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Luana L Scheffer, Sen Chandra Sreetama, Nimisha Sharma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanism of Ca²⁺-triggered ESCRT assembly and regulation of cell membrane repair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms6646"}], "href": "https://doi.org/10.1038/ncomms6646"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25534348"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25534348"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Cody J Vild, Yan Li, Emily Z Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel mechanism of regulating the ATPase VPS4 by its cofactor LIP5 and the endosomal sorting complex required for transport (ESCRT)-III protein CHMP5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.616730"}], "href": "https://doi.org/10.1074/jbc.M114.616730"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25637630"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25637630"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Shimon Harel, Yarin Altaras, Dikla Nachmias, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of individual HIV-1 budding event using fast AFM reveals a multiplexed role for VPS4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biophys J (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bpj.2022.08.035"}], "href": "https://doi.org/10.1016/j.bpj.2022.08.035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36042696"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36042696"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "H Helen Lin, Xu Li, Jo-Lin Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of an AAA ATPase VPS4B-dependent pathway that modulates epidermal growth factor receptor abundance and signaling during hypoxia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.06053-11"}], "href": "https://doi.org/10.1128/MCB.06053-11"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22252323"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22252323"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Yifei Liu, Liting Lv, Qun Xue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vacuolar protein sorting 4B, an ATPase protein positively regulates the progression of NSCLC via promoting cell division."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-013-1699-2"}], "href": "https://doi.org/10.1007/s11010-013-1699-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23737133"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23737133"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Dongmei Zhang, Liang Wang, Lijun Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vacuolar protein sorting 4B regulates apoptosis of intestinal epithelial cells via p38 MAPK in Crohn's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Pathol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexmp.2014.12.007"}], "href": "https://doi.org/10.1016/j.yexmp.2014.12.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25533544"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25533544"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Emily Z Guo, Zhaohui Xu "}, {"type": "b", "children": [{"type": "t", "text": "Distinct mechanisms of recognizing endosomal sorting complex required for transport III (ESCRT-III) protein IST1 by different microtubule interacting and trafficking (MIT) domains."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.607903"}], "href": "https://doi.org/10.1074/jbc.M114.607903"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25657007"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25657007"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Jie Tang, Lili Ji, Yuchan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell adhesion down-regulates the expression of vacuolar protein sorting 4B (VPS4B) and contributes to drug resistance in multiple myeloma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Hematol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12185-015-1783-3"}], "href": "https://doi.org/10.1007/s12185-015-1783-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25804841"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25804841"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Libin Xu, Leilei Zhai, Qingtian Ge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vacuolar Protein Sorting 4B (VPS4B) Regulates Apoptosis of Chondrocytes via p38 Mitogen-Activated Protein Kinases (MAPK) in Osteoarthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Inflammation (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10753-017-0633-2"}], "href": "https://doi.org/10.1007/s10753-017-0633-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28744712"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28744712"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Yuhua Pan, Ting Lu, Ling Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vacuolar protein sorting 4B regulates the proliferation and odontoblastic differentiation of human dental pulp stem cells through the Wnt-β-catenin signalling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Artif Cells Nanomed Biotechnol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21691401.2019.1629950"}], "href": "https://doi.org/10.1080/21691401.2019.1629950"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31218890"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31218890"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Ewelina Szymańska, Paulina Nowak, Krzysztof Kolmus, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/emmm.201910812"}], "href": "https://doi.org/10.15252/emmm.201910812"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31930723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31930723"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Qiang Li, Fangli Lu, Tianxuan Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VPS4B mutation impairs the osteogenic differentiation of dental follicle cells derived from a patient with dentin dysplasia type I."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oral Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41368-020-00088-z"}], "href": "https://doi.org/10.1038/s41368-020-00088-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32737282"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32737282"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Jasper E Neggers, Brenton R Paolella, Adhana Asfaw, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2020.108493"}], "href": "https://doi.org/10.1016/j.celrep.2020.108493"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33326793"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33326793"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Wen-Qiang Lai, Hou-Fu Xia, Gao-Hong Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p-AKT/VPS4B regulates the small extracellular vesicle size in venous malformation endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oral Dis (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/odi.14608"}], "href": "https://doi.org/10.1111/odi.14608"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37154262"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37154262"}]}]}]}