| HGNC Family | Non-coding RNAs |
| Name | vault RNA 2-1 |
| Description | This gene produces an RNA polymerase III transcript that resembles both a component of the ribonucleoprotein vault particle and a pre-microRNA. However, the RNA product does not function as a vault or microRNA; rather, it acts as a direct inhibitor of protein kinase R (also known as eukaryotic translation initiation factor 2-alpha kinase 2, EIF2AK2), and thereby plays an important role in the regulation of cell growth. This gene is located in the vicinity of a differentially methylated region (DMR) and is imprinted and may show allele-specific expression. This gene is also often hypermethylated and repressed in cancers. [provided by RefSeq, Nov 2015] |
| Synonyms | MIR886, pre-miR-886, NC886, VTRNA2, svtRNA2-1a, CBL3, MIRN886, HSA-MIR-886, HVG-5 |
| NCBI Gene ID | 100126299 |
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| Predicted Functions |
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| Expression in Tissues and Cell Lines |
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VTRNA2-1 has 1,006 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 11 datasets.
Click the + buttons to view associations for VTRNA2-1 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of VTRNA2-1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at VTRNA2-1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of VTRNA2-1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of VTRNA2-1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with VTRNA2-1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of VTRNA2-1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of VTRNA2-1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of VTRNA2-1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of VTRNA2-1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of VTRNA2-1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at VTRNA2-1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
