{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nVexin, a protein encoded by the C8orf46 gene, has emerged as an important factor in embryonic neurogenesis. Its altered mRNA levels in patients with psychiatric and neurological diseases underscore its potential relevance to neurodevelopmental and neuropsychiatric pathologies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn cultured rat cortical neurons, brain‐derived neurotrophic factor (BDNF) was found to upregulate Vexin mRNA, suggesting that Vexin may act as a downstream mediator in BDNF–dependent signaling pathways. The study in question investigates the regulatory mechanisms behind this BDNF-induced expression, aiming to uncover how Vexin contributes to both normal neuronal development and disease-related processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hisatsugu Koshimizu, Shingo Suzuki, Anna Kawai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vexin is upregulated in cerebral cortical neurons by brain-derived neurotrophic factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuropsychopharmacol Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/npr2.12119"}], "href": "https://doi.org/10.1002/npr2.12119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32558188"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32558188"}]}]}]}