{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn lung adenocarcinoma (LUAD), WDFY3‑AS2 is markedly up‐regulated, and its transcription is enhanced by the upstream factor USF1. Functionally, increased WDFY3‑AS2 expression promotes cell proliferation, migration, and invasion while inhibiting apoptosis. Mechanistically, WDFY3‑AS2 acts by binding and sequestering miR‑491‑5p, thereby relieving its inhibition on the oncogene zinc finger protein 703 (ZNF703), which further drives LUAD progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of breast cancer, although detailed functional studies remain limited, dysregulation of long non‑coding RNAs such as WDFY3‑AS2 is frequently observed. These findings suggest that WDFY3‑AS2 may play an important regulatory role in breast cancer tumorigenesis and could represent a novel candidate for further investigation as both a biomarker and a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn esophageal squamous cell carcinoma (ESCC), WDFY3‑AS2 is typically down‑regulated in tumor tissues and cell lines. Reduced expression of WDFY3‑AS2 correlates with advanced TNM stage, lymph node metastasis, and poor patient prognosis. Functional experiments demonstrated that overexpression of WDFY3‑AS2 suppresses cell proliferation, invasion, and epithelial‑to‑mesenchymal transition (EMT) by acting as a competing endogenous RNA (ceRNA) to sponge miR‑2355‑5p. This sequestration enhances the expression of SOCS2, which in turn dampens the JAK2/Stat5 signaling pathway—an axis critical for tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nEmerging evidence in oral squamous cell carcinoma (OSCC) highlights the dual nature of WDFY3‑AS2 in cancer biology. In OSCC, WDFY3‑AS2 has been linked to the modulation of β‑catenin expression and the regulation of tumor immunity, indicating that its impact on the disease is multifaceted. These findings underscore the complexity of WDFY3‑AS2’s roles across different cancer types and support its potential as both a prognostic biomarker and a therapeutic target in OSCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ping Ren, Xiaodong Hong, Liang Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "USF1-induced overexpression of long noncoding RNA WDFY3-AS2 promotes lung adenocarcinoma progression via targeting miR-491-5p/ZNF703 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.23181"}], "href": "https://doi.org/10.1002/mc.23181"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32275336"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32275336"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Daniel Rodrigues de Bastos, Maria A Nagai "}, {"type": "b", "children": [{"type": "t", "text": "In silico analyses identify lncRNAs: WDFY3-AS2, BDNF-AS and AFAP1-AS1 as potential prognostic factors for patients with triple-negative breast tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0232284"}], "href": "https://doi.org/10.1371/journal.pone.0232284"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32401758"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32401758"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Qing Zhang, Fangxia Guan, Tianli Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA WDFY3-AS2 suppresses proliferation and invasion in oesophageal squamous cell carcinoma by regulating miR-2355-5p/SOCS2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.15488"}], "href": "https://doi.org/10.1111/jcmm.15488"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32536038"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32536038"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiang Lin, Jian-Ming Ding, Xiong-Zhou Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Immunity-related long noncoding RNA WDFY3-AS2 inhibited cell proliferation and metastasis through Wnt/β-catenin signaling in oral squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Oral Biol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.archoralbio.2023.105625"}], "href": "https://doi.org/10.1016/j.archoralbio.2023.105625"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36657277"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36657277"}]}]}]}