WDR82 Gene

HGNC Family	WD repeat domain containing (WDR)
Name	WD repeat domain 82
Description	TMEM113 (WDR82) is a component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase complexes (Lee and Skalnik, 2005 [PubMed 16253997]; Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Jul 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nWDR82 functions as a key adaptor within human Set1/COMPASS complexes that catalyze histone H3 lysine 4 trimethylation—a chromatin mark associated with active transcription. In mammalian cells, WDR82 specifically associates with the Set1A/B complexes and is required for their efficient recruitment to transcription start sites by binding the Ser5‐phosphorylated C-terminal domain of RNA polymerase II. Through this interaction, WDR82 facilitates the widespread deposition of H3K4me3 at promoters, underscoring its critical role in transcription initiation and chromatin modification."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its central function in histone methylation, WDR82 is involved in the regulation of chromatin-related processes during cell cycle progression. It forms part of a multiprotein network that includes protein phosphatase 1 (PP1) and its regulatory subunits, contributing to the assembly of the PTW/PP1 phosphatase complex. This complex plays an essential role in chromosome decondensation at mitotic exit, thereby linking WDR82 to the broader regulation of the cell cycle and maintenance of chromatin structure."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nWDR82 also contributes to transcriptional fidelity by participating in a checkpoint mechanism that modulates divergent antisense transcription at promoter regions. In association with its RNA-binding partner ZC3H4, WDR82 helps to regulate the processing of enhancer-generated and promoter-antisense long noncoding RNAs that are inefficiently spliced, thus ensuring that these cis-regulatory elements maintain proper transcriptional output."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in transcription and chromatin regulation, WDR82 functions as a negative regulator in innate antiviral signaling pathways. Localized on mitochondria, it interacts with TRAF3 to promote K48-linked polyubiquitination, thereby suppressing virus-triggered type I interferon responses. This activity highlights a cell type-specific function of WDR82 in modulating antiviral defense mechanisms."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nStructural investigations have provided further insight into the assembly of WDR82 with histone methyltransferase complexes. Studies of the RRM domains of SETD1A and SETD1B reveal potential RNA-binding activities and demonstrate that an intrinsically disordered region within these catalytic subunits mediates binding to WDR82. This structural framework underscores the molecular basis for WDR82’s recruitment capabilities and its integration into diverse regulatory complexes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Min Wu, Peng Fei Wang, Jung Shin Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00976-08"}], "href": "https://doi.org/10.1128/MCB.00976-08"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18838538"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18838538"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jeong-Heon Lee, David G Skalnik "}, {"type": "b", "children": [{"type": "t", "text": "Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01356-07"}], "href": "https://doi.org/10.1128/MCB.01356-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17998332"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17998332"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jeong-Heon Lee, Jinsam You, Erika Dobrota, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and characterization of a novel human PP1 phosphatase complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.109801"}], "href": "https://doi.org/10.1074/jbc.M110.109801"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20516061"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20516061"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Liv M I Austenaa, Viviana Piccolo, Marta Russo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A first exon termination checkpoint preferentially suppresses extragenic transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41594-021-00572-y"}], "href": "https://doi.org/10.1038/s41594-021-00572-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33767452"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33767452"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kun Zhu, Xiang Wang, Lin-Gao Ju, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WDR82 Negatively Regulates Cellular Antiviral Response by Mediating TRAF3 Polyubiquitination in Multiple Cell Lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1500339"}], "href": "https://doi.org/10.4049/jimmunol.1500339"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26519536"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26519536"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Kihyun Park, Jian Zhong, Jin Sung Jang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZWC complex-mediated SPT5 phosphorylation suppresses divergent antisense RNA transcription at active gene promoters."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkac193"}], "href": "https://doi.org/10.1093/nar/gkac193"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35325203"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35325203"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Sijia Bao, Chao Xu "}, {"type": "b", "children": [{"type": "t", "text": "Molecular insight into the SETD1A/B N-terminal region and its interaction with WDR82."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2023.03.064"}], "href": "https://doi.org/10.1016/j.bbrc.2023.03.064"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37030068"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37030068"}]}]}]}
Synonyms	MST107, PRO34047, WDR82A, SWD2, MSTP107, PRO2730, TMEM113
Proteins	WDR82_HUMAN
NCBI Gene ID	80335
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

WDR82 has 6,978 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 107 datasets.

Click the + buttons to view associations for WDR82 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

WDR82 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of WDR82 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of WDR82 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of WDR82 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of WDR82 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of WDR82 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of WDR82 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of WDR82 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of WDR82 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of WDR82 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of WDR82 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of WDR82 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of WDR82 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with WDR82 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of WDR82 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of WDR82 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of WDR82 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of WDR82 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of WDR82 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing WDR82 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing WDR82 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with WDR82 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with WDR82 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing WDR82 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with WDR82 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with WDR82 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with WDR82 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with WDR82 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with WDR82 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with WDR82 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with WDR82 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at WDR82 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of WDR82 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of WDR82 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing WDR82 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of WDR82 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with WDR82 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing WDR82 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of WDR82 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of WDR82 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of WDR82 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.