{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nWSPAR, also known as lncTCF7, is a long noncoding RNA that acts as an oncogenic regulator in glioma pathology. In glioma, increased WSPAR expression is observed in tumor tissues compared to normal brain, and its levels correlate with higher WHO grades and larger tumor sizes. Functionally, knockdown of WSPAR in glioma cells leads to significant inhibition of migration, proliferation, and tumorigenicity both in vitro and in vivo. Moreover, under hypoxic conditions, glioma cells induce WSPAR expression through an autocrine IL-6 mechanism, emphasizing its role in promoting tumor progression and its potential as a prognostic biomarker and therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in glioma, WSPAR/lncTCF7 has been implicated in multiple myeloma, where elevated levels are associated with adverse clinicopathological features and poorer prognosis. This suggests that WSPAR may contribute broadly to tumorigenesis by modulating cellular pathways that drive proliferation and survival across different cancer types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiao Gao, Xing Guo, Hao Xue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncTCF7 is a negative prognostic factor, and knockdown of lncTCF7 inhibits migration, proliferation and tumorigenicity in glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-17340-y"}], "href": "https://doi.org/10.1038/s41598-017-17340-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29234033"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29234033"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Cui Zhang, Min Chu, Yingchao Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA T-cell factor 7 in multiple myeloma: A potential biomarker for deteriorated clinical features and poor prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.23400"}], "href": "https://doi.org/10.1002/jcla.23400"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32578294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32578294"}]}]}]}