{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nWWTR1-AS1 is a long noncoding RNA that has emerged as an important player in the oncogenesis of various human cancers. Aberrant upregulation of this lncRNA has been observed in tumor tissues, and its overexpression is linked with aggressive clinical features in malignant diseases. These findings highlight the potential of WWTR1-AS1 as both a prognostic biomarker and a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn head and neck squamous cell carcinoma (HNSCC), detailed analyses have revealed that WWTR1-AS1 is significantly overexpressed compared to adjacent non-tumor mucosa. Elevated levels of WWTR1-AS1 correlate strongly with larger tumor size, cervical node metastasis, and poorer patient prognosis. Functional studies further demonstrate that knockdown of WWTR1-AS1 markedly inhibits cell proliferation, migration, invasion, tumorsphere formation, and resistance to apoptosis, likely by modulating the stability of its sense partner, WWTR1 mRNA."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSimilarly, investigations in cervical squamous cell carcinoma (CSCC) have focused on elucidating the role of WWTR1-AS1 in disease progression. Although specific mechanistic insights in CSCC require further exploration, preliminary findings suggest that this lncRNA may be involved in promoting oncogenic behaviors in cervical tumors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jin Li, Zhongwu Li, Yaping Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of lncRNA WWTR1-AS1 associates with tumor aggressiveness and unfavorable survival in head-neck squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29132"}], "href": "https://doi.org/10.1002/jcb.29132"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31172583"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31172583"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaofeng Zhou, Zhizun Li, Moyu Li "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA WWTR1-AS1 upregulates Notch3 through miR-136 to increase cancer cell stemness in cervical squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Womens Health (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12905-024-02905-7"}], "href": "https://doi.org/10.1186/s12905-024-02905-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38331752"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38331752"}]}]}]}