Name | X antigen family, member 1B |
Description | This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene, in addition to alternative transcription start sites, results in multiple transcript variants. [provided by RefSeq, Jan 2010] |
Synonyms | CT12.1B, XAGE1A, CT12.1A |
NCBI Gene ID | 653220 |
API | |
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Predicted Functions |
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Co-expressed Genes |
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Expression in Tissues and Cell Lines |
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XAGE1B has 378 functional associations with biological entities spanning 6 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 21 datasets.
Click the + buttons to view associations for XAGE1B from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
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COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with XAGE1B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of XAGE1B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
CTD Gene-Disease Associations | diseases associated with XAGE1B gene/protein from the curated CTD Gene-Disease Associations dataset. | |
DISEASES Text-mining Gene-Disease Assocation Evidence Scores | diseases co-occuring with XAGE1B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of XAGE1B gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of XAGE1B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with XAGE1B gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of XAGE1B gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of XAGE1B gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of XAGE1B gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of XAGE1B gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Gene Expression Profiles | tissues with high or low expression of XAGE1B gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of XAGE1B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of XAGE1B gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
LOCATE Curated Protein Localization Annotations | cellular components containing XAGE1B protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain XAGE1B protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
Pathway Commons Protein-Protein Interactions | interacting proteins for XAGE1B from the Pathway Commons Protein-Protein Interactions dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of XAGE1B gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of XAGE1B protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with XAGE1B protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TRANSFAC Predicted Transcription Factor Targets | transcription factors regulating expression of XAGE1B gene predicted using known transcription factor binding site motifs from the TRANSFAC Predicted Transcription Factor Targets dataset. | |