{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nXGY2, which in the presented study corresponds to TMEM263, encodes a plasma membrane protein that plays a critical role in postnatal growth and skeletal development. Disruption of this gene in mice causes severe postnatal growth failure and proportional dwarfism, primarily due to impaired activation of the growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis. The deletion of XGY2 leads to low circulating IGF-1 levels, reduced hepatic GH receptor expression, and diminished GH-induced JAK2/STAT5 signaling, culminating in impaired bone acquisition and growth plate development. This molecular deficit also results in substantial alterations in the hepatic transcriptome, with the liver expression profiles of knockout male mice resembling those of wild-type females and other models of GH insensitivity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Together, the findings underscore the essential role of XGY2 in regulating key endocrine pathways that drive longitudinal bone growth, establishing its causal involvement in mediating the effects of GH signaling on postnatal development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dylan C Sarver, Jean Garcia-Diaz, Muzna Saqib, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tmem263 deletion disrupts the GH/IGF-1 axis and causes dwarfism and impairs skeletal acquisition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.90949"}], "href": "https://doi.org/10.7554/eLife.90949"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38241182"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38241182"}]}]}]}