{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent evidence indicates that YJU2B functions as a subunit within the evolutionarily conserved Integrator complex that associates with the C-terminal domain of RNA polymerase II. The Integrator complex is essential for recruiting processing factors to U1 and U2 small nuclear RNA (snRNA) genes, thereby mediating the 3′ end processing of these transcripts. In this context, YJU2B—along with at least 11 other novel subunits—likely contributes to the precise recognition and cleavage of nascent snRNA transcripts, a process reminiscent of the roles played by components of the cleavage and polyadenylation specificity factor (CPSF) complex."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nAdditionally, the recruitment of the Integrator complex, including YJU2B, to snRNA genes underscores a broader regulatory mechanism that links transcription and RNA processing. This coordinated function is vital for the maturation of snRNAs, which in turn are crucial for spliceosome assembly and accurate mRNA splicing in metazoans."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "David Baillat, Mohamed-Ali Hakimi, Anders M Näär, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2005.08.019"}], "href": "https://doi.org/10.1016/j.cell.2005.08.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16239144"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16239144"}]}]}]}