YKT6 Gene

Name	YKT6 v-SNARE homolog (S. cerevisiae)
Description	This gene product is one of the SNARE recognition molecules implicated in vesicular transport between secretory compartments. It is a membrane associated, isoprenylated protein that functions at the endoplasmic reticulum-Golgi transport step. This protein is highly conserved from yeast to human and can functionally complement the loss of the yeast homolog in the yeast secretory pathway. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nYKT6 is a multifunctional soluble N‐ethylmaleimide–sensitive factor attachment protein receptor (SNARE) that plays diverse roles in intracellular membrane trafficking. In the context of macroautophagy, YKT6 contributes to autophagosome–lysosome fusion by forming a complex with SNAP29 and the lysosomal SNARE syntaxin 7, acting in parallel with the STX17‐mediated pathway. Its recruitment to autophagosomes depends on its N‑terminal longin domain, distinguishing its targeting from the conventional Golgi localization that requires palmitoylation and farnesylation. Moreover, YKT6 is implicated in intra‐Golgi transport, being part of a distinct SNARE complex with GS15, syntaxin 5, and GS28, and its regulation via double prenylation by the novel geranylgeranyltransferase‐III is essential for proper Golgi architecture and vesicle fusion. In addition, recent evidence suggests that YKT6 can cooperate with STX17 and SNAP29 to prime the membrane fusion machinery during autophagy."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn oncogenesis and tumor progression, YKT6 has emerged as an important regulator of exosome production and release, thereby affecting intercellular communication and metastasis. For example, in non–small cell lung cancer, YKT6 is involved in the regulation of cancer‐derived exosomes, and in oral squamous cell carcinoma, its overexpression is linked to enhanced metastatic potential and an immunosuppressive tumor microenvironment. Furthermore, YKT6 modulates epithelial cell migration and invasion by affecting the integrity of adherens and tight junctions through microRNA‐directed pathways, with its altered expression serving as a candidate prognostic biomarker across multiple tumor types as shown in pan–cancer analyses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in vesicular trafficking and cancer, YKT6 is also critical in the cellular response to lysosomal stress associated with neurodegenerative disorders. In Parkinson’s disease models, for instance, YKT6 is normally activated during lysosomal stress to promote hydrolase trafficking and clearance, but aberrant binding by pathogenic α‑synuclein deactivates YKT6 and impairs this clearance mechanism. Notably, despite its broad functions in membrane fusion events, YKT6 has not yet been linked to Mendelian disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Takahide Matsui, Peidu Jiang, Saori Nakano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201712058"}], "href": "https://doi.org/10.1083/jcb.201712058"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29789439"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29789439"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yue Xu, Sally Martin, David E James, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e02-01-0004"}], "href": "https://doi.org/10.1091/mbc.e02-01-0004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12388752"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12388752"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ryutaro Shirakawa, Sakurako Goto-Ito, Kota Goto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A SNARE geranylgeranyltransferase essential for the organization of the Golgi apparatus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.2019104120"}], "href": "https://doi.org/10.15252/embj.2019104120"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32128853"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32128853"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Denghao Zheng, Mindan Tong, Shen Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human YKT6 forms priming complex with STX17 and SNAP29 to facilitate autophagosome-lysosome fusion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2024.113760"}], "href": "https://doi.org/10.1016/j.celrep.2024.113760"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38340317"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38340317"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Marc Ruiz-Martinez, Alfons Navarro, Ramón M Marrades, et al. "}, {"type": "b", "children": [{"type": "t", "text": "YKT6 expression, exosome release, and survival in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.9862"}], "href": "https://doi.org/10.18632/oncotarget.9862"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27285987"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27285987"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Zongcheng Yang, Guangxing Yan, Lixin Zheng, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "YKT6"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": ", as a potential predictor of prognosis and immunotherapy response for oral squamous cell carcinoma, is related to cell invasion, metastasis, and CD8+ T cell infiltration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncoimmunology (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/2162402X.2021.1938890"}], "href": "https://doi.org/10.1080/2162402X.2021.1938890"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34221701"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34221701"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Nayden G Naydenov, Supriya Joshi, Alex Feygin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A membrane fusion protein, Ykt6, regulates epithelial cell migration via microRNA-mediated suppression of Junctional Adhesion Molecule A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2018.1496755"}], "href": "https://doi.org/10.1080/15384101.2018.1496755"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30010460"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30010460"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jia-Ze Xu, Jun-Jie Jiang, Hao-Jie Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High expression of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "YKT6"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " associated with progression and poor prognosis of hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Scand J Gastroenterol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/00365521.2021.1961305"}], "href": "https://doi.org/10.1080/00365521.2021.1961305"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34396876"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34396876"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Xuezhong Zhang, Mark Lloyd G Dapar, Xin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A pan-cancer analysis of the oncogenic role of YKT6 in human tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Medicine (Baltimore) (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MD.0000000000033546"}], "href": "https://doi.org/10.1097/MD.0000000000033546"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37058019"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37058019"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Leah K Cuddy, Willayat Y Wani, Martino L Morella, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuron.2019.09.001"}], "href": "https://doi.org/10.1016/j.neuron.2019.09.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31648898"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31648898"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Mengqi Ma, Mythily Ganapathi, Yiming Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Homozygous missense variants in YKT6 result in loss of function and are associated with developmental delay, with or without severe infantile liver disease and risk for hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Med (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gim.2024.101125"}], "href": "https://doi.org/10.1016/j.gim.2024.101125"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38522068"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38522068"}]}]}]}
Proteins	YKT6_HUMAN
NCBI Gene ID	10652
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

YKT6 has 8,729 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 117 datasets.

Click the + buttons to view associations for YKT6 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

YKT6 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of YKT6 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of YKT6 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of YKT6 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of YKT6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of YKT6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of YKT6 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of YKT6 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of YKT6 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of YKT6 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of YKT6 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of YKT6 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of YKT6 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with YKT6 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of YKT6 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of YKT6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of YKT6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing YKT6 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of YKT6 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing YKT6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing YKT6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing YKT6 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing YKT6 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with YKT6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with YKT6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of YKT6 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with YKT6 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with YKT6 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with YKT6 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of YKT6 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with YKT6 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with YKT6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with YKT6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with YKT6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with YKT6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at YKT6 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of YKT6 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of YKT6 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing YKT6 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of YKT6 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with YKT6 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.