Name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta |
Description | This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe YWHAH gene, which encodes the 14-3-3η isoform, has been implicated in critical neuronal signaling and neurodevelopmental processes. Several studies have explored its genetic variation and association with neuropsychiatric disorders such as schizophrenia, bipolar disorder, and prion diseases, while also demonstrating interactions with key nuclear regulators like p33ING1b that influence cellular localization in neuronal cells. (See."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the immune system and inflammatory diseases, particularly rheumatoid arthritis (RA), 14-3-3η plays a dual role. It is not only present in synovial fluids of patients with inflamed joints but also actively participates in signal transduction—such as facilitating MDA5-dependent type I interferon induction—thereby modulating innate immune responses. Its elevated expression has been linked to disease severity and poor clinical outcomes, establishing its potential as an accurate diagnostic and prognostic biomarker in RA. (See."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nYWHAH is also a significant player in cancer and metabolic regulation. In pituitary oncocytomas, for example, 14-3-3η overexpression has been implicated in the inhibition of glycolysis via direct interaction with lactate dehydrogenase A, contributing to mitochondrial biogenesis under conditions of compromised oxidative phosphorylation. Moreover, in hepatocellular carcinoma, a miR-660-5p/YWHAH axis has been shown to activate PI3K/AKT signaling and promote cell migration and invasion, while in papillary thyroid cancer, a circular RNA acts as a sponge for miR-1178-3p to upregulate YWHAH, thus enhancing malignant behavior and angiogenesis. Additionally, emerging evidence from studies in dental pulp stem cells suggests a regulatory role for YWHAH in differentiation processes. (See."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond these disease contexts, 14-3-3η is involved in various other vital cellular functions. It contributes to cell survival and protective responses; for instance, studies in amyotrophic lateral sclerosis (ALS) demonstrate its synaptic and cytoplasmic roles in anterior horn cells, while interactions with Cdc42 have highlighted its participation in modulating apoptosis and DNA damage responses. It also plays a role in defining the stoichiometry of neuronal nicotinic acetylcholine receptors via cytosolic molecular chaperoning, protects endothelial progenitor cells from oxidized low-density lipoprotein–induced damage through an interaction with BCL-2, and is implicated in bone metabolism and osteoporosis via a microRNA-mediated mechanism. (See."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these findings underscore the multifaceted roles of YWHAH/14-3-3η across diverse biological systems. Whether modulating neuronal signaling and psychiatric phenotypes, orchestrating inflammatory responses and innate immunity in rheumatoid arthritis, regulating cancer cell metabolism and progression, or safeguarding cellular homeostasis in neurodegeneration and tissue differentiation, YWHAH represents a compelling diagnostic biomarker and therapeutic target for a wide array of human diseases. (See also"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "and"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "for further insights).\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "R Bell, J Munro, C Russ, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Systematic screening of the 14-3-3 eta (eta) chain gene for polymorphic variants and case-control analysis in schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet (2000)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11121172"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11121172"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hong-Sheng Wang, Shi-Wei Duan, Qing-He Xing, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Association study between NPY and YWHAH gene polymorphisms and schizophrenia]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Yi Chuan Xue Bao (2005)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16459651"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16459651"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Deepak Grover, Ranjana Verma, Fernando S Goes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Family-based association of YWHAH in psychotic bipolar disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet B Neuropsychiatr Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.b.30927"}], "href": "https://doi.org/10.1002/ajmg.b.30927"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19160447"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19160447"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiao-Han Li, Akira Noguchi, Takeshi Nishida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cytoplasmic expression of p33ING1b is correlated with tumorigenesis and progression of head and neck squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histol Histopathol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14670/HH-26.597"}], "href": "https://doi.org/10.14670/HH-26.597"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21432775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21432775"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jisuk Yun, Byung-Hoon Jeong, Hae-Jung Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A polymorphism in the YWHAH gene encoding 14-3-3 eta that is not associated with sporadic Creutzfeldt-Jakob disease (CJD)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-011-1136-0"}], "href": "https://doi.org/10.1007/s11033-011-1136-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21739144"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21739144"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Walter P Maksymowych, Désirée van der Heijde, Cornelia F Allaart, et al. "}, {"type": "b", "children": [{"type": "t", "text": "14-3-3η is a novel mediator associated with the pathogenesis of rheumatoid arthritis and joint damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Res Ther (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/ar4547"}], "href": "https://doi.org/10.1186/ar4547"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24751211"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24751211"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Tingting Zeng, Liming Tan "}, {"type": "b", "children": [{"type": "t", "text": "14-3-3η protein: a promising biomarker for rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomark Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2217/bmm-2017-0385"}], "href": "https://doi.org/10.2217/bmm-2017-0385"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30022679"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30022679"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jhih-Pu Lin, Yu-Kuan Fan, Helene Minyi Liu "}, {"type": "b", "children": [{"type": "t", "text": "The 14-3-3η chaperone protein promotes antiviral innate immunity via facilitating MDA5 oligomerization and intracellular redistribution."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.1007582"}], "href": "https://doi.org/10.1371/journal.ppat.1007582"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30742689"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30742689"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Wafaa T El-Sherif, Dalia A Nigm, Mona H Abd-Elsamea, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evaluation of Serum Protein 14-3-3η (Eta) as a Novel Biomarker for Rheumatoid Arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Egypt J Immunol (2019)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31333006"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31333006"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Shaimaa A Fattah, Maha A Abdel Fattah, Noha M Mesbah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "YWHAH Genetic Variants are Associated with Increased Hypoxia Inducible Factor-1α/Vascular Endothelial Growth Factor in Egyptian Rheumatoid Arthritis Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Genet (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10528-022-10202-x"}], "href": "https://doi.org/10.1007/s10528-022-10202-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35190930"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35190930"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yun-Jui Chan, Nien-Tzu Liu, Fu Hsin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Temporal regulation of MDA5 inactivation by Caspase-3 dependent cleavage of 14-3-3η."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.1012287"}], "href": "https://doi.org/10.1371/journal.ppat.1012287"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38843304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38843304"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jie Feng, Qi Zhang, Chuzhong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhancement of mitochondrial biogenesis and paradoxical inhibition of lactate dehydrogenase mediated by 14-3-3η in oncocytomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pathol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/path.5090"}], "href": "https://doi.org/10.1002/path.5090"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29704241"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29704241"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yunyu Wu, Yan Zhang, Feng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-660-5p promotes the progression of hepatocellular carcinoma by interaction with YWHAH via PI3K/Akt signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2020.07.034"}], "href": "https://doi.org/10.1016/j.bbrc.2020.07.034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32807493"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32807493"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yinli Ma, Dan Yang, Pingan Guo "}, {"type": "b", "children": [{"type": "t", "text": "Circ_0000144 acts as a miR-1178-3p decoy to promote cell malignancy and angiogenesis by increasing YWHAH expression in papillary thyroid cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Otolaryngol Head Neck Surg (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s40463-022-00574-w"}], "href": "https://doi.org/10.1186/s40463-022-00574-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35902926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35902926"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Shu Diao, Xiao Han, Wei Long Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GREM1 Negatively Regulates Osteo-/Dentinogenic Differentiation of Dental Pulp Stem Cells via Association with YWHAH."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Chin J Dent Res (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3290/j.cjdr.b5698390"}], "href": "https://doi.org/10.3290/j.cjdr.b5698390"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39221981"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39221981"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Takahiko Umahara, Toshiki Uchihara, Noriyuki Shibata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "14-3-3 eta isoform colocalizes TDP-43 on the coarse granules in the anterior horn cells of patients with sporadic amyotrophic lateral sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.brainres.2016.05.051"}], "href": "https://doi.org/10.1016/j.brainres.2016.05.051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27256400"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27256400"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Luiz E Silva, Renan C Souza, Eduardo S Kitano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proteomic and Interactome Approaches Reveal PAK4, PHB-2, and 14-3-3η as Targets of Overactivated Cdc42 in Cellular Responses to Genomic Instability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteome Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.jproteome.9b00260"}], "href": "https://doi.org/10.1021/acs.jproteome.9b00260"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31478661"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31478661"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Simone Mazzaferro, Sara T Whiteman, Constanza Alcaino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NACHO and 14-3-3 promote expression of distinct subunit stoichiometries of the α4β2 acetylcholine receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-020-03592-x"}], "href": "https://doi.org/10.1007/s00018-020-03592-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32676916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32676916"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Hui Zhou, Xiaopei Sun, Yi Dai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "14-3-3-η interacts with BCL-2 to protect human endothelial progenitor cells from ox-LDL-triggered damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Int (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cbin.12105"}], "href": "https://doi.org/10.1002/cbin.12105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38100125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38100125"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Ya-Qian Liu, Yue-Chen Xu, Zong-Wen Shuai "}, {"type": "b", "children": [{"type": "t", "text": "Mir-142-3P regulates MAPK protein family by inhibiting 14-3-3η to enhance bone marrow mesenchymal stem cells osteogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-023-48950-4"}], "href": "https://doi.org/10.1038/s41598-023-48950-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38129425"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38129425"}]}]}]}
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Synonyms | YWHA1 |
Proteins | 1433F_HUMAN |
NCBI Gene ID | 7533 |
API | |
Download Associations | |
Predicted Functions |
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Co-expressed Genes |
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Expression in Tissues and Cell Lines |
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YWHAH has 8,973 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 122 datasets.
Click the + buttons to view associations for YWHAH from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
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Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of YWHAH gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of YWHAH gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of YWHAH gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of YWHAH gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of YWHAH gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
Biocarta Pathways | pathways involving YWHAH protein from the Biocarta Pathways dataset. | |
BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of YWHAH gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of YWHAH gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of YWHAH gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of YWHAH gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of YWHAH gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
CCLE Cell Line Gene Mutation Profiles | cell lines with YWHAH gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset. | |
CCLE Cell Line Proteomics | Cell lines associated with YWHAH protein from the CCLE Cell Line Proteomics dataset. | |
CellMarker Gene-Cell Type Associations | cell types associated with YWHAH gene from the CellMarker Gene-Cell Type Associations dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of YWHAH gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of YWHAH gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of YWHAH gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of YWHAH gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing YWHAH protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing YWHAH protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Experimental Protein Localization Evidence Scores | cellular components containing YWHAH protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with YWHAH protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with YWHAH protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
CORUM Protein Complexes | protein complexs containing YWHAH protein from the CORUM Protein Complexes dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with YWHAH gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Chemical Interactions | chemicals interacting with YWHAH gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
CTD Gene-Disease Associations | diseases associated with YWHAH gene/protein from the curated CTD Gene-Disease Associations dataset. | |
DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of YWHAH protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
DepMap CRISPR Gene Dependency | cell lines with fitness changed by YWHAH gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with YWHAH gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with YWHAH gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with YWHAH gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with YWHAH gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with YWHAH gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at YWHAH gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of YWHAH gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of YWHAH gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing YWHAH from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GAD Gene-Disease Associations | diseases associated with YWHAH gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
GAD High Level Gene-Disease Associations | diseases associated with YWHAH gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of YWHAH gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with YWHAH gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing YWHAH from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of YWHAH gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of YWHAH gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of YWHAH gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of YWHAH gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of YWHAH gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of YWHAH gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GO Biological Process Annotations 2015 | biological processes involving YWHAH gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving YWHAH gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving YWHAH gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing YWHAH protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Cellular Component Annotations 2023 | cellular components containing YWHAH protein from the curated GO Cellular Component Annotations 2023 dataset. | |
GO Cellular Component Annotations 2025 | cellular components containing YWHAH protein from the curated GO Cellular Component Annotations 2025 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by YWHAH gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GO Molecular Function Annotations 2023 | molecular functions performed by YWHAH gene from the curated GO Molecular Function Annotations 2023 dataset. | |
GO Molecular Function Annotations 2025 | molecular functions performed by YWHAH gene from the curated GO Molecular Function Annotations 2025 dataset. | |
GTEx eQTL 2025 | SNPs regulating expression of YWHAH gene from the GTEx eQTL 2025 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of YWHAH gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of YWHAH gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of YWHAH gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of YWHAH gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of YWHAH gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Gene Expression Profiles | tissues with high or low expression of YWHAH gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of YWHAH protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of YWHAH gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
HPM Cell Type and Tissue Protein Expression Profiles | cell types and tissues with high or low expression of YWHAH protein relative to other cell types and tissues from the HPM Cell Type and Tissue Protein Expression Profiles dataset. | |
Hub Proteins Protein-Protein Interactions | interacting hub proteins for YWHAH from the curated Hub Proteins Protein-Protein Interactions dataset. | |
HuGE Navigator Gene-Phenotype Associations | phenotypes associated with YWHAH gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for YWHAH protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of YWHAH gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
KEA Substrates of Kinases | kinases that phosphorylate YWHAH protein from the curated KEA Substrates of Kinases dataset. | |
KEGG Pathways | pathways involving YWHAH protein from the KEGG Pathways dataset. | |
Kinase Library Serine Threonine Kinome Atlas | kinases that phosphorylate YWHAH protein from the Kinase Library Serine Threonine Atlas dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of YWHAH gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of YWHAH gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with YWHAH gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of YWHAH gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of YWHAH gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of YWHAH gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of YWHAH gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
LOCATE Curated Protein Localization Annotations | cellular components containing YWHAH protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain YWHAH protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MiRTarBase microRNA Targets | microRNAs targeting YWHAH gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of YWHAH gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of YWHAH gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
MSigDB Cancer Gene Co-expression Modules | co-expressed genes for YWHAH from the MSigDB Cancer Gene Co-expression Modules dataset. | |
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of YWHAH gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
NURSA Protein Complexes | protein complexs containing YWHAH protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
PANTHER Pathways | pathways involving YWHAH protein from the PANTHER Pathways dataset. | |
Pathway Commons Protein-Protein Interactions | interacting proteins for YWHAH from the Pathway Commons Protein-Protein Interactions dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of YWHAH gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of YWHAH gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PFOCR Pathway Figure Associations 2023 | pathways involving YWHAH protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving YWHAH protein from the Wikipathways PFOCR 2024 dataset. | |
Phosphosite Textmining Biological Term Annotations | biological terms co-occuring with YWHAH protein in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset. | |
PID Pathways | pathways involving YWHAH protein from the PID Pathways dataset. | |
Reactome Pathways 2014 | pathways involving YWHAH protein from the Reactome Pathways dataset. | |
Reactome Pathways 2024 | pathways involving YWHAH protein from the Reactome Pathways 2024 dataset. | |
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of YWHAH gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of YWHAH gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of YWHAH gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of YWHAH gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of YWHAH gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at YWHAH gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of YWHAH gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of YWHAH gene from the RummaGEO Gene Perturbation Signatures dataset. | |
Sanger Dependency Map Cancer Cell Line Proteomics | cell lines associated with YWHAH protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset. | |
SynGO Synaptic Gene Annotations | synaptic terms associated with YWHAH gene from the SynGO Synaptic Gene Annotations dataset. | |
Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of YWHAH gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of YWHAH gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of YWHAH gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of YWHAH gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of YWHAH protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of YWHAH protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of YWHAH protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of YWHAH protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with YWHAH protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with YWHAH protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
WikiPathways Pathways 2014 | pathways involving YWHAH protein from the Wikipathways Pathways 2014 dataset. | |
WikiPathways Pathways 2024 | pathways involving YWHAH protein from the WikiPathways Pathways 2024 dataset. | |