YWHAH Gene

Name	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
Description	This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe YWHAH gene, which encodes the 14-3-3η isoform, has been implicated in critical neuronal signaling and neurodevelopmental processes. Several studies have explored its genetic variation and association with neuropsychiatric disorders such as schizophrenia, bipolar disorder, and prion diseases, while also demonstrating interactions with key nuclear regulators like p33ING1b that influence cellular localization in neuronal cells. (See."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the immune system and inflammatory diseases, particularly rheumatoid arthritis (RA), 14-3-3η plays a dual role. It is not only present in synovial fluids of patients with inflamed joints but also actively participates in signal transduction—such as facilitating MDA5-dependent type I interferon induction—thereby modulating innate immune responses. Its elevated expression has been linked to disease severity and poor clinical outcomes, establishing its potential as an accurate diagnostic and prognostic biomarker in RA. (See."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nYWHAH is also a significant player in cancer and metabolic regulation. In pituitary oncocytomas, for example, 14-3-3η overexpression has been implicated in the inhibition of glycolysis via direct interaction with lactate dehydrogenase A, contributing to mitochondrial biogenesis under conditions of compromised oxidative phosphorylation. Moreover, in hepatocellular carcinoma, a miR-660-5p/YWHAH axis has been shown to activate PI3K/AKT signaling and promote cell migration and invasion, while in papillary thyroid cancer, a circular RNA acts as a sponge for miR-1178-3p to upregulate YWHAH, thus enhancing malignant behavior and angiogenesis. Additionally, emerging evidence from studies in dental pulp stem cells suggests a regulatory role for YWHAH in differentiation processes. (See."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond these disease contexts, 14-3-3η is involved in various other vital cellular functions. It contributes to cell survival and protective responses; for instance, studies in amyotrophic lateral sclerosis (ALS) demonstrate its synaptic and cytoplasmic roles in anterior horn cells, while interactions with Cdc42 have highlighted its participation in modulating apoptosis and DNA damage responses. It also plays a role in defining the stoichiometry of neuronal nicotinic acetylcholine receptors via cytosolic molecular chaperoning, protects endothelial progenitor cells from oxidized low-density lipoprotein–induced damage through an interaction with BCL-2, and is implicated in bone metabolism and osteoporosis via a microRNA-mediated mechanism. (See."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these findings underscore the multifaceted roles of YWHAH/14-3-3η across diverse biological systems. Whether modulating neuronal signaling and psychiatric phenotypes, orchestrating inflammatory responses and innate immunity in rheumatoid arthritis, regulating cancer cell metabolism and progression, or safeguarding cellular homeostasis in neurodegeneration and tissue differentiation, YWHAH represents a compelling diagnostic biomarker and therapeutic target for a wide array of human diseases. (See also"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "and"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "for further insights).\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "R Bell, J Munro, C Russ, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Systematic screening of the 14-3-3 eta (eta) chain gene for polymorphic variants and case-control analysis in schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet (2000)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11121172"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11121172"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hong-Sheng Wang, Shi-Wei Duan, Qing-He Xing, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Association study between NPY and YWHAH gene polymorphisms and schizophrenia]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Yi Chuan Xue Bao (2005)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16459651"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16459651"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Deepak Grover, Ranjana Verma, Fernando S Goes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Family-based association of YWHAH in psychotic bipolar disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet B Neuropsychiatr Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.b.30927"}], "href": "https://doi.org/10.1002/ajmg.b.30927"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19160447"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19160447"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiao-Han Li, Akira Noguchi, Takeshi Nishida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cytoplasmic expression of p33ING1b is correlated with tumorigenesis and progression of head and neck squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histol Histopathol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14670/HH-26.597"}], "href": "https://doi.org/10.14670/HH-26.597"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21432775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21432775"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jisuk Yun, Byung-Hoon Jeong, Hae-Jung Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A polymorphism in the YWHAH gene encoding 14-3-3 eta that is not associated with sporadic Creutzfeldt-Jakob disease (CJD)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-011-1136-0"}], "href": "https://doi.org/10.1007/s11033-011-1136-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21739144"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21739144"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Walter P Maksymowych, Désirée van der Heijde, Cornelia F Allaart, et al. "}, {"type": "b", "children": [{"type": "t", "text": "14-3-3η is a novel mediator associated with the pathogenesis of rheumatoid arthritis and joint damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Res Ther (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/ar4547"}], "href": "https://doi.org/10.1186/ar4547"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24751211"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24751211"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Tingting Zeng, Liming Tan "}, {"type": "b", "children": [{"type": "t", "text": "14-3-3η protein: a promising biomarker for rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomark Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2217/bmm-2017-0385"}], "href": "https://doi.org/10.2217/bmm-2017-0385"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30022679"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30022679"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jhih-Pu Lin, Yu-Kuan Fan, Helene Minyi Liu "}, {"type": "b", "children": [{"type": "t", "text": "The 14-3-3η chaperone protein promotes antiviral innate immunity via facilitating MDA5 oligomerization and intracellular redistribution."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.1007582"}], "href": "https://doi.org/10.1371/journal.ppat.1007582"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30742689"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30742689"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Wafaa T El-Sherif, Dalia A Nigm, Mona H Abd-Elsamea, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evaluation of Serum Protein 14-3-3η (Eta) as a Novel Biomarker for Rheumatoid Arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Egypt J Immunol (2019)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31333006"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31333006"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Shaimaa A Fattah, Maha A Abdel Fattah, Noha M Mesbah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "YWHAH Genetic Variants are Associated with Increased Hypoxia Inducible Factor-1α/Vascular Endothelial Growth Factor in Egyptian Rheumatoid Arthritis Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Genet (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10528-022-10202-x"}], "href": "https://doi.org/10.1007/s10528-022-10202-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35190930"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35190930"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yun-Jui Chan, Nien-Tzu Liu, Fu Hsin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Temporal regulation of MDA5 inactivation by Caspase-3 dependent cleavage of 14-3-3η."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.1012287"}], "href": "https://doi.org/10.1371/journal.ppat.1012287"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38843304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38843304"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jie Feng, Qi Zhang, Chuzhong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhancement of mitochondrial biogenesis and paradoxical inhibition of lactate dehydrogenase mediated by 14-3-3η in oncocytomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pathol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/path.5090"}], "href": "https://doi.org/10.1002/path.5090"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29704241"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29704241"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yunyu Wu, Yan Zhang, Feng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-660-5p promotes the progression of hepatocellular carcinoma by interaction with YWHAH via PI3K/Akt signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2020.07.034"}], "href": "https://doi.org/10.1016/j.bbrc.2020.07.034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32807493"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32807493"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yinli Ma, Dan Yang, Pingan Guo "}, {"type": "b", "children": [{"type": "t", "text": "Circ_0000144 acts as a miR-1178-3p decoy to promote cell malignancy and angiogenesis by increasing YWHAH expression in papillary thyroid cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Otolaryngol Head Neck Surg (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s40463-022-00574-w"}], "href": "https://doi.org/10.1186/s40463-022-00574-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35902926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35902926"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Shu Diao, Xiao Han, Wei Long Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GREM1 Negatively Regulates Osteo-/Dentinogenic Differentiation of Dental Pulp Stem Cells via Association with YWHAH."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Chin J Dent Res (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3290/j.cjdr.b5698390"}], "href": "https://doi.org/10.3290/j.cjdr.b5698390"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39221981"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39221981"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Takahiko Umahara, Toshiki Uchihara, Noriyuki Shibata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "14-3-3 eta isoform colocalizes TDP-43 on the coarse granules in the anterior horn cells of patients with sporadic amyotrophic lateral sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.brainres.2016.05.051"}], "href": "https://doi.org/10.1016/j.brainres.2016.05.051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27256400"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27256400"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Luiz E Silva, Renan C Souza, Eduardo S Kitano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proteomic and Interactome Approaches Reveal PAK4, PHB-2, and 14-3-3η as Targets of Overactivated Cdc42 in Cellular Responses to Genomic Instability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteome Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.jproteome.9b00260"}], "href": "https://doi.org/10.1021/acs.jproteome.9b00260"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31478661"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31478661"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Simone Mazzaferro, Sara T Whiteman, Constanza Alcaino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NACHO and 14-3-3 promote expression of distinct subunit stoichiometries of the α4β2 acetylcholine receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-020-03592-x"}], "href": "https://doi.org/10.1007/s00018-020-03592-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32676916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32676916"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Hui Zhou, Xiaopei Sun, Yi Dai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "14-3-3-η interacts with BCL-2 to protect human endothelial progenitor cells from ox-LDL-triggered damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Int (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cbin.12105"}], "href": "https://doi.org/10.1002/cbin.12105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38100125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38100125"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Ya-Qian Liu, Yue-Chen Xu, Zong-Wen Shuai "}, {"type": "b", "children": [{"type": "t", "text": "Mir-142-3P regulates MAPK protein family by inhibiting 14-3-3η to enhance bone marrow mesenchymal stem cells osteogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-023-48950-4"}], "href": "https://doi.org/10.1038/s41598-023-48950-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38129425"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38129425"}]}]}]}
Synonyms	YWHA1
Proteins	1433F_HUMAN
NCBI Gene ID	7533
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

YWHAH has 8,973 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 122 datasets.

Click the + buttons to view associations for YWHAH from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

YWHAH Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of YWHAH gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of YWHAH gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of YWHAH gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of YWHAH gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of YWHAH gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving YWHAH protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of YWHAH gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of YWHAH gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of YWHAH gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of YWHAH gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of YWHAH gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with YWHAH gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with YWHAH protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with YWHAH gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of YWHAH gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of YWHAH gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of YWHAH gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of YWHAH gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing YWHAH protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing YWHAH protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing YWHAH protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with YWHAH protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with YWHAH protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing YWHAH protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with YWHAH gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with YWHAH gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with YWHAH gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of YWHAH protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by YWHAH gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with YWHAH gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with YWHAH gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with YWHAH gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with YWHAH gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with YWHAH gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at YWHAH gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of YWHAH gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of YWHAH gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing YWHAH from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with YWHAH gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with YWHAH gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.