{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLong noncoding RNAs have emerged as key players in tumorigenesis, and this study sheds light on the role of lncRNA ZBED5‑AS1 in lung adenocarcinoma (LUAD). The researchers observed that ZBED5‑AS1 is significantly upregulated in LUAD specimens and cell lines, where its overexpression promotes cell proliferation, migration, and invasion in vitro, and enhances tumor growth in vivo. These findings suggest that ZBED5‑AS1 functions as an oncogenic factor in LUAD."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistically, the study demonstrated that ZBED5‑AS1 induces the expression of ZNF146, which in turn activates the ATR/Chk1 signaling pathway—an important driver of LUAD progression. Additionally, exosome analyses revealed that exosomes from LUAD cells contain higher levels of ZBED5‑AS1 compared to those derived from normal respiratory epithelial cells. Coculture experiments further showed that lowering the exosomal expression of ZBED5‑AS1 attenuates the aggressive phenotypes of LUAD cells, underscoring its pivotal role in tumor development and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Feng Jiang, Xiaolu Huang, Liqun Ling, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA ZBED5-AS1 Facilitates Tumor Progression and Metastasis in Lung Adenocarcinoma via ZNF146/ATR/Chk1 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms241813925"}], "href": "https://doi.org/10.3390/ijms241813925"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37762228"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37762228"}]}]}]}