{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent findings have begun to implicate the long noncoding RNA ZBTB11‐AS1 as a potential regulator of gene expression changes in arrhythmogenic cardiomyopathy (ACM), a disease marked by progressive myocardial degeneration replaced by fibro‐fatty tissue, arrhythmias, and sudden death. Although the exact molecular function of ZBTB11‐AS1 remains to be fully elucidated, alterations in its expression have been observed alongside local transcriptional changes associated with tissue remodeling in ACM. Such observations suggest that ZBTB11‐AS1 may play a role in modulating pathways that govern the loss of cardiomyocytes and the subsequent fibrofatty replacement, thereby contributing to the complex pathological landscape of ACM."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn this context, ZBTB11‐AS1 emerges as a promising candidate for further investigation into how noncoding RNAs can influence cardiac remodeling. By potentially integrating signals that affect cellular structure and function, ZBTB11‐AS1 could help orchestrate the remodeling processes that lead to disease progression. Understanding its involvement may not only clarify key regulatory mechanisms underlying ACM but also open avenues for innovative therapeutic strategies targeting local gene expression changes driving myocardial degeneration and fibro‐fatty infiltration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Cornelis J Boogerd, Grégory P A Lacraz, Ábel Vértesy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Spatial transcriptomics unveils ZBTB11 as a regulator of cardiomyocyte degeneration in arrhythmogenic cardiomyopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiovasc Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/cvr/cvac072"}], "href": "https://doi.org/10.1093/cvr/cvac072"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35576477"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35576477"}]}]}]}