{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLong non‐coding RNA ZFAS1 plays divergent roles in mammary biology. In normal mouse mammary development as well as in breast cancer, ZFAS1 is highly expressed in the ducts and alveoli and appears to promote proper epithelial cell differentiation while restraining proliferation, suggesting a tumor‐suppressive function in these settings."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBy stark contrast, in a broad spectrum of solid tumors—including hepatocellular carcinoma, colorectal, gastric, colonic, glioma, ovarian, cervical, nasopharyngeal, head and neck, thyroid, melanoma, and clear cell renal cell carcinoma—ZFAS1 is frequently up‐regulated and exerts oncogenic functions. In these cancers, elevated ZFAS1 levels are strongly associated with enhanced cell proliferation, migration, invasion, epithelial–mesenchymal transition, metastasis, and even chemoresistance, all of which contribute to poor patient prognosis. Mechanistically, ZFAS1 acts principally as a competing endogenous RNA by sequestering multiple tumor‐suppressive microRNAs (for example, miR‑150‑5p, miR‑7‑5p, miR‑200b, miR‑27a, among others) and thereby de‐repressing key oncogenic targets such as transcription factors, matrix metalloproteinases, VEGFA, and other regulators that feed into critical signaling pathways including Wnt/β‑catenin, Notch, and Akt/mTOR."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "39"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its variable roles in cancer, ZFAS1 exerts regulatory influences in several non‐neoplastic disorders. Studies demonstrate that ZFAS1 modulates inflammatory responses, cell apoptosis, oxidative stress, and ferroptosis in conditions such as osteoarthritis, cerebral ischemia reperfusion injury, polycystic ovary syndrome, atherosclerosis, and diabetic retinopathy. In these diverse pathological settings, ZFAS1 similarly functions through interactions with specific microRNAs and protein effectors, underscoring its potential as a therapeutic target across multiple disease paradigms."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "40", "end_ref": "44"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Marjan E Askarian-Amiri, Joanna Crawford, Juliet D French, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1261/rna.2528811"}], "href": "https://doi.org/10.1261/rna.2528811"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21460236"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21460236"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shulin Fan, Chunni Fan, Ning Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of the long non-coding RNA ZFAS1 is associated with cell proliferation, migration and invasion in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.8707"}], "href": "https://doi.org/10.3892/mmr.2018.8707"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29532866"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29532866"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tao Li, Junjie Xie, Chuan Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Amplification of Long Noncoding RNA ZFAS1 Promotes Metastasis in Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-14-3721"}], "href": "https://doi.org/10.1158/0008-5472.CAN-14-3721"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26069248"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26069248"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Nithyananda Thorenoor, Petra Faltejskova-Vychytilova, Sonja Hombach, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.5807"}], "href": "https://doi.org/10.18632/oncotarget.5807"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26506418"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26506418"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Fengqi Nie, Xiang Yu, Mingde Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA ZFAS1 promotes gastric cancer cells proliferation by epigenetically repressing KLF2 and NKD2 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.9611"}], "href": "https://doi.org/10.18632/oncotarget.9611"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27246976"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27246976"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Weili Wang, Chungen Xing "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of long noncoding RNA ZFAS1 predicts poor prognosis and prompts invasion and metastasis in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2016.05.003"}], "href": "https://doi.org/10.1016/j.prp.2016.05.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27461828"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27461828"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Hu Zhou, Fubing Wang, Hao Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased expression of long-noncoding RNA ZFAS1 is associated with epithelial-mesenchymal transition of gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.101048"}], "href": "https://doi.org/10.18632/aging.101048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27654478"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27654478"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Changyi Fang, Jianbao Zan, Ben Yue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding ribonucleic acid zinc finger antisense 1 promotes the progression of colonic cancer by modulating ZEB1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gastroenterol Hepatol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jgh.13646"}], "href": "https://doi.org/10.1111/jgh.13646"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27862275"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27862275"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Kai Gao, Zhiwu Ji, Kun She, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA ZFAS1 is an unfavourable prognostic factor and promotes glioma cell progression by activation of the Notch signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2017.01.014"}], "href": "https://doi.org/10.1016/j.biopha.2017.01.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28081466"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28081466"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Bairong Xia, Yan Hou, Hong Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA ZFAS1 interacts with miR-150-5p to regulate Sp1 expression and ovarian cancer cell malignancy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.14663"}], "href": "https://doi.org/10.18632/oncotarget.14663"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28099946"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28099946"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Lei Pan, Wei Liang, Min Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomes-mediated transfer of long noncoding RNA ZFAS1 promotes gastric cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Clin Oncol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00432-017-2361-2"}], "href": "https://doi.org/10.1007/s00432-017-2361-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28285404"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28285404"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Qiao-Li Lv, Shu-Hui Chen, Xue Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of long noncoding RNA zinc finger antisense 1 enhances epithelial-mesenchymal transition in vitro and predicts poor prognosis in glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1010428317695022"}], "href": "https://doi.org/10.1177/1010428317695022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28349823"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28349823"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Esra Baytak, Qiang Gong, Burcu Akman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Whole transcriptome analysis reveals dysregulated oncogenic lncRNAs in natural killer/T-cell lymphoma and establishes MIR155HG as a target of PRDM1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1010428317701648"}], "href": "https://doi.org/10.1177/1010428317701648"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28468592"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28468592"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yang Ye, Xiaomei Gao, Nanping Yang "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA ZFAS1 promotes cell migration and invasion of fibroblast-like synoviocytes by suppression of miR-27a in rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Cell (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13577-017-0179-5"}], "href": "https://doi.org/10.1007/s13577-017-0179-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28721682"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28721682"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Shuping Xie, Quanxing Ge, Xueyan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA ZFAS1 sponges miR-484 to promote cell proliferation and invasion in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2017.1407895"}], "href": "https://doi.org/10.1080/15384101.2017.1407895"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29179614"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29179614"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Weiran Xu, Liang He, Ying Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of lncRNA ZFAS1 inhibits malignancies by blocking Wnt/β-catenin signaling in gastric cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Biotechnol Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/09168451.2018.1431518"}], "href": "https://doi.org/10.1080/09168451.2018.1431518"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29424266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29424266"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Ping Luo, Chunzi Liang, Xianwei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of long non-coding RNA "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "ZFAS1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " as a novel biomarker for diagnosis of HCC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20171359"}], "href": "https://doi.org/10.1042/BSR20171359"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29559565"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29559565"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Jin-Shan Wang, Qing-Hong Liu, Xiao-Hua Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The long noncoding RNA ZFAS1 facilitates bladder cancer tumorigenesis by sponging miR-329."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2018.04.031"}], "href": "https://doi.org/10.1016/j.biopha.2018.04.031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29653362"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29653362"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Haifan Yang, Ge Li, Bo Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZFAS1 functions as an oncogenic long non-coding RNA in bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20180475"}], "href": "https://doi.org/10.1042/BSR20180475"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29678899"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29678899"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "X Chen, J Li, C-L Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA ZFAS1 promotes nasopharyngeal carcinoma through activation of Wnt/β-catenin pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201806_15165"}], "href": "https://doi.org/10.26355/eurrev_201806_15165"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29917194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29917194"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Xiaoxiang Chen, Kaixuan Zeng, Mu Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SP1-induced lncRNA-ZFAS1 contributes to colorectal cancer progression via the miR-150-5p/VEGFA axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-018-0962-6"}], "href": "https://doi.org/10.1038/s41419-018-0962-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30250022"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30250022"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Anbang He, Shiming He, Xuesong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZFAS1: A novel vital oncogenic lncRNA in multiple human cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Prolif (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cpr.12513"}], "href": "https://doi.org/10.1111/cpr.12513"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30288832"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30288832"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Silin Gan, Ping Ma, Jie Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of ZFAS1 suppresses the progression of acute myeloid leukemia by regulating microRNA-150/Sp1 and microRNA-150/Myb pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Pharmacol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejphar.2018.11.036"}], "href": "https://doi.org/10.1016/j.ejphar.2018.11.036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30502345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30502345"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Lan-Lan Feng, Fang-Rong Shen, Jin-Hua Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of the lncRNA ZFAS1 in cervical cancer and its correlation with prognosis and chemosensitivity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2019.01.025"}], "href": "https://doi.org/10.1016/j.gene.2019.01.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30738960"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30738960"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Liangliang Shi, Xiaohua Hong, Li Ba, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA ZNFX1-AS1 promotes the tumor progression and metastasis of colorectal cancer by acting as a competing endogenous RNA of miR-144 to regulate EZH2 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-019-1332-8"}], "href": "https://doi.org/10.1038/s41419-019-1332-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30770796"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30770796"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Dan Dong, Zhongyi Mu, Ning Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA ZFAS1 promotes proliferation and metastasis of clear cell renal cell carcinoma via targeting miR-10a/SKA1 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2018.12.143"}], "href": "https://doi.org/10.1016/j.biopha.2018.12.143"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30841471"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30841471"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Lili Liang, Zhixin Zhang, Xiaowei Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA ZFAS1 promotes tumorigenesis through regulation of miR-150-5p/RAB9A in melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Melanoma Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/CMR.0000000000000595"}], "href": "https://doi.org/10.1097/CMR.0000000000000595"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30889053"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30889053"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Fan Zhang, Ying Li, Weiran Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA ZFAS1 regulates the malignant progression of gastric cancer via the microRNA-200b-3p/Wnt1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Biotechnol Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/09168451.2019.1606697"}], "href": "https://doi.org/10.1080/09168451.2019.1606697"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30999814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30999814"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Tomasz Kolenda, Kacper Guglas, Magda Kopczyńska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncogenic Role of ZFAS1 lncRNA in Head and Neck Squamous Cell Carcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells8040366"}], "href": "https://doi.org/10.3390/cells8040366"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31010087"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31010087"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Chuan-Gang Han, Yan Huang, Lu Qin "}, {"type": "b", "children": [{"type": "t", "text": "Long Non-Coding RNA ZFAS1 as a Novel Potential Biomarker for Predicting the Prognosis of Thyroid Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.912921"}], "href": "https://doi.org/10.12659/MSM.912921"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31012438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31012438"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Gongli Yang, Banghua Han, Tao Feng "}, {"type": "b", "children": [{"type": "t", "text": "ZFAS1 knockdown inhibits viability and enhances cisplatin cytotoxicity by up-regulating miR-432-5p in glioma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Basic Clin Pharmacol Toxicol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/bcpt.13286"}], "href": "https://doi.org/10.1111/bcpt.13286"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31246330"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31246330"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Xiaoqiong Wang, Qiaozhi Jin, Xue Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA ZFAS1 promotes proliferation and migration and inhibits apoptosis in nasopharyngeal carcinoma via the PI3K/AKT pathway in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-182080"}], "href": "https://doi.org/10.3233/CBM-182080"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31403940"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31403940"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Xiaojian Li, Yidan Luo, Liang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The long noncoding RNA ZFAS1 promotes the progression of glioma by regulating the miR-150-5p/PLP2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29199"}], "href": "https://doi.org/10.1002/jcp.29199"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31535380"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31535380"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Zhenglong Li, Xingming Jiang, Lining Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Up-regulation of ZFAS1 indicates dismal prognosis for cholangiocarcinoma and promotes proliferation and metastasis by modulating USF1 via miR-296-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.14698"}], "href": "https://doi.org/10.1111/jcmm.14698"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31565837"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31565837"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Zhirong Li, Xuebo Qin, Wei Bian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal lncRNA ZFAS1 regulates esophageal squamous cell carcinoma cell proliferation, invasion, migration and apoptosis via microRNA-124/STAT3 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-019-1473-8"}], "href": "https://doi.org/10.1186/s13046-019-1473-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31775815"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31775815"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Xiaoqiang Tang, Ruohan Yin, Haifeng Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA ZFAS1 confers inflammatory responses and reduces cholesterol efflux in atherosclerosis through regulating miR-654-3p-ADAM10/RAB22A axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cardiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ijcard.2020.03.056"}], "href": "https://doi.org/10.1016/j.ijcard.2020.03.056"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32349937"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32349937"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Huizhe Wu, Wenyan Qin, Senxu Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA ZFAS1 promoting small nucleolar RNA-mediated 2'-O-methylation via NOP58 recruitment in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-020-01201-w"}], "href": "https://doi.org/10.1186/s12943-020-01201-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32443980"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32443980"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Xiufang Wang, Zhikun Wu, Wenyan Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA ZFAS1 promotes colorectal cancer tumorigenesis and development through DDX21-POLR1B regulatory axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.103875"}], "href": "https://doi.org/10.18632/aging.103875"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33202381"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33202381"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Senxu Lu, Li Han, Xiaoyun Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "N6-methyladenosine reader IMP2 stabilizes the ZFAS1/OLA1 axis and activates the Warburg effect: implication in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hematol Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13045-021-01204-0"}], "href": "https://doi.org/10.1186/s13045-021-01204-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34743750"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34743750"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Dong Ye, Weihong Jian, Jie Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of long noncoding RNA ZFAS1 in proliferation, apoptosis and migration of chondrocytes in osteoarthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2018.04.124"}], "href": "https://doi.org/10.1016/j.biopha.2018.04.124"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29703568"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29703568"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Yanyan Zhang, Yiping Zhang "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA ZFAS1 Improves Neuronal Injury and Inhibits Inflammation, Oxidative Stress, and Apoptosis by Sponging miR-582 and Upregulating NOS3 Expression in Cerebral Ischemia/Reperfusion Injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Inflammation (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10753-020-01212-1"}], "href": "https://doi.org/10.1007/s10753-020-01212-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32180078"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32180078"}]}, {"type": "r", "ref": 42, "children": [{"type": "t", "text": "Hong-Li Zhu, Yue-Qun Chen, Zhi-Fen Zhang "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of lncRNA ZFAS1 and upregulation of microRNA-129 repress endocrine disturbance, increase proliferation and inhibit apoptosis of ovarian granulosa cells in polycystic ovarian syndrome by downregulating HMGB1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygeno.2020.04.011"}], "href": "https://doi.org/10.1016/j.ygeno.2020.04.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32320818"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32320818"}]}, {"type": "r", "ref": 43, "children": [{"type": "t", "text": "Shanshan Yang, Wei Yin, Yan Ding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lnc RNA ZFAS1 regulates the proliferation, apoptosis, inflammatory response and autophagy of fibroblast-like synoviocytes via miR-2682-5p/ADAMTS9 axis in rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20201273"}], "href": "https://doi.org/10.1042/BSR20201273"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32744323"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32744323"}]}, {"type": "r", "ref": 44, "children": [{"type": "t", "text": "Yu Liu, Zhengyu Zhang, Jing Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA ZFAS1 Positively Facilitates Endothelial Ferroptosis via miR-7-5p/ACSL4 Axis in Diabetic Retinopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oxid Med Cell Longev (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/9004738"}], "href": "https://doi.org/10.1155/2022/9004738"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36092160"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36092160"}]}]}]}