{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have highlighted ZNF252P‐AS1, an antisense long noncoding RNA, as a potential molecular regulator in ovarian cancer. In studies aimed at deciphering its function, researchers have explored the role of ZNF252P‐AS1 in modulating gene expression, cellular proliferation, and other tumor‐promoting pathways in ovarian carcinoma, suggesting that it may contribute to disease progression and serve as a possible therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn parallel, research on keloid formation has underscored the importance of the JAK2/STAT3 signaling pathway in driving fibroproliferative processes. Although the mechanisms upstream of this pathway’s activation remain to be fully elucidated, emerging insights raise the possibility that noncoding RNAs, including ZNF252P‐AS1, could act as regulatory molecules modulating these signaling cascades, thereby impacting pathological scar formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTogether, these studies propose that ZNF252P‐AS1 may function as an important molecular mediator in diverse pathologies by influencing gene regulatory networks and signal transduction pathways. Further characterization of its mechanistic roles could pave the way for novel diagnostic markers and therapeutic strategies in ovarian cancer and fibrotic conditions.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Li Geng, Zhongqiu Wang, Yongju Tian "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of ZNF252P-AS1 alleviates ovarian cancer progression by binding miR-324-3p to downregulate LY6K."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Ovarian Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13048-021-00933-7"}], "href": "https://doi.org/10.1186/s13048-021-00933-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34980214"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34980214"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yu Guo, Mengjuan Li, Jianhong Long, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA-ZNF252P-AS1/miR-15b-5p promotes the proliferation of keloid fibroblast by regulating the BTF3-STAT3 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Dermatol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jdermsci.2022.12.010"}], "href": "https://doi.org/10.1016/j.jdermsci.2022.12.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36641250"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36641250"}]}]}]}