{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations into gene-environment interactions have highlighted the increasing global burden of atherosclerosis (AS) and underscored the pivotal role of endothelial cell autophagy in this disease. In particular, dysregulation of autophagy can contribute to endothelial dysfunction, especially when autophagic activity becomes excessive during the later stages of AS."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nEmerging evidence implicates the long noncoding RNA ZNF295‐AS1 as a potential regulator of endothelial autophagy. Although the current abstract primarily discusses the autophagic processes in the context of AS, early data suggest that ZNF295‐AS1 may influence the fine balance of autophagy in endothelial cells by interacting with gene-environment factors. This regulatory capacity positions ZNF295‐AS1 as a promising candidate for further studies aimed at understanding its role in mitigating the excessive autophagy that characterizes the end stage of AS."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Q-W Qin, J Yuan, L Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZNF295-AS1 inhibits autophagy via the ZNF295-AS1/miR-508-5p/ATG7 axis in AS."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202006_21695"}], "href": "https://doi.org/10.26355/eurrev_202006_21695"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32633396"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32633396"}]}]}]}