{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe collection of abstracts provided offers an in‐depth look into the molecular components essential for inner ear function. In particular, they describe how proteins such as cadherin 23 (CDH23) and its interacting partners (including protocadherin‐15, harmonin, myosin VIIa, among others) form and maintain the tip links between hair cell stereocilia. These tip links are critical for converting mechanical stimuli into electrochemical signals—that is, for mechanoelectrical transduction—which underlies hearing and balance. Additionally, the studies explore how mutations or splicing defects in CDH23 and related genes contribute to various forms of hearing loss (including age‐related, congenital, and syndromic deafness) by disrupting tip link integrity, hair bundle organization, or downstream signaling pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "41"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIt is important to note that although the title of your query mentions ZNF337, none of the abstracts examined provide any data, analysis, or discussion pertaining to this particular zinc finger protein. In essence, while the studies elaborate on genetic mutations, protein interactions, alternative splicing, and the consequences of perturbations in CDH23 and its partners on auditory and vestibular function, they do not address any function, expression pattern, or potential role for ZNF337. Consequently, no conclusions regarding ZNF337’s function can be drawn from the present collection, and further targeted research will be needed to elucidate whether and how ZNF337 impacts inner ear or other biological processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "41"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ralph H Holme, Karen P Steel "}, {"type": "b", "children": [{"type": "t", "text": "Stereocilia defects in waltzer (Cdh23), shaker1 (Myo7a) and double waltzer/shaker1 mutant mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hear Res (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0378-5955(02)00334-9"}], "href": "https://doi.org/10.1016/s0378-5955(02"}, {"type": "t", "text": "00334-9) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12121736"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12121736"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jan Siemens, Piotr Kazmierczak, Anna Reynolds, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.232579599"}], "href": "https://doi.org/10.1073/pnas.232579599"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12407180"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12407180"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Batiste Boëda, Aziz El-Amraoui, Amel Bahloul, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/emboj/cdf689"}], "href": "https://doi.org/10.1093/emboj/cdf689"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12485990"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12485990"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Konrad Noben-Trauth, Qing Yin Zheng, Kenneth R Johnson "}, {"type": "b", "children": [{"type": "t", "text": "Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng1226"}], "href": "https://doi.org/10.1038/ng1226"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12910270"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12910270"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ralph H Holme, Karen P Steel "}, {"type": "b", "children": [{"type": "t", "text": "Progressive hearing loss and increased susceptibility to noise-induced hearing loss in mice carrying a Cdh23 but not a Myo7a mutation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Assoc Res Otolaryngol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10162-003-4021-2"}], "href": "https://doi.org/10.1007/s10162-003-4021-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14648237"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14648237"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jan Siemens, Concepcion Lillo, Rachel A Dumont, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cadherin 23 is a component of the tip link in hair-cell stereocilia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature02483"}], "href": "https://doi.org/10.1038/nature02483"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15057245"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15057245"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Qing Yin Zheng, Denise Yan, Xiao Mei Ouyang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Digenic inheritance of deafness caused by mutations in genes encoding cadherin 23 and protocadherin 15 in mice and humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddi010"}], "href": "https://doi.org/10.1093/hmg/ddi010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15537665"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15537665"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Vincent Michel, Richard J Goodyear, Dominique Weil, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cadherin 23 is a component of the transient lateral links in the developing hair bundles of cochlear sensory cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2005.01.014"}], "href": "https://doi.org/10.1016/j.ydbio.2005.01.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15882573"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15882573"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ayala Lagziel, Zubair M Ahmed, Julie M Schultz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Spatiotemporal pattern and isoforms of cadherin 23 in wild type and waltzer mice during inner ear hair cell development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2005.01.015"}], "href": "https://doi.org/10.1016/j.ydbio.2005.01.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15882574"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15882574"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Satoshi Yonezawa, Norio Yoshizaki, Takashi Kageyama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fates of Cdh23/CDH23 with mutations affecting the cytoplasmic region."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.20266"}], "href": "https://doi.org/10.1002/humu.20266"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16281288"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16281288"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Piotr Kazmierczak, Hirofumi Sakaguchi, Joshua Tokita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature06091"}], "href": "https://doi.org/10.1038/nature06091"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17805295"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17805295"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Qing Yin Zheng, Dalian Ding, Heping Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A locus on distal chromosome 10 (ahl4) affecting age-related hearing loss in A/J mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Aging (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neurobiolaging.2007.12.011"}], "href": "https://doi.org/10.1016/j.neurobiolaging.2007.12.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18280008"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18280008"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Kenneth R Johnson, Chantal Longo-Guess, Leona H Gagnon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A locus on distal chromosome 11 (ahl8) and its interaction with Cdh23 ahl underlie the early onset, age-related hearing loss of DBA/2J mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygeno.2008.06.007"}], "href": "https://doi.org/10.1016/j.ygeno.2008.06.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18662770"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18662770"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "A K Rzadzinska, K P Steel "}, {"type": "b", "children": [{"type": "t", "text": "Presence of interstereocilial links in waltzer mutants suggests Cdh23 is not essential for tip link formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroscience (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuroscience.2008.10.012"}], "href": "https://doi.org/10.1016/j.neuroscience.2008.10.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18996172"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18996172"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Martin Schwander, Wei Xiong, Joshua Tokita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0900691106"}], "href": "https://doi.org/10.1073/pnas.0900691106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19270079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19270079"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Ayala Lagziel, Nora Overlack, Steven L Bernstein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of cadherin 23 isoforms is not conserved: implications for a mouse model of Usher syndrome type 1D."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Vis (2009)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19756182"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19756182"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Marcos Sotomayor, Wilhelm A Weihofen, Rachelle Gaudet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural determinants of cadherin-23 function in hearing and deafness."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuron.2010.03.028"}], "href": "https://doi.org/10.1016/j.neuron.2010.03.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20399731"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20399731"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Kenneth R Johnson, Heping Yu, Dalian Ding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Separate and combined effects of Sod1 and Cdh23 mutations on age-related hearing loss and cochlear pathology in C57BL/6J mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hear Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.heares.2010.05.002"}], "href": "https://doi.org/10.1016/j.heares.2010.05.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20470874"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20470874"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Amel Bahloul, Vincent Michel, Jean-Pierre Hardelin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddq271"}], "href": "https://doi.org/10.1093/hmg/ddq271"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20639393"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20639393"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "F Han, H Yu, C Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A new mouse mutant of the Cdh23 gene with early-onset hearing loss facilitates evaluation of otoprotection drugs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenomics J (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/tpj.2010.60"}], "href": "https://doi.org/10.1038/tpj.2010.60"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20644563"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20644563"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Andrea Lelli, Piotr Kazmierczak, Yoshiyuki Kawashima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Development and regeneration of sensory transduction in auditory hair cells requires functional interaction between cadherin-23 and protocadherin-15."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.1949-10.2010"}], "href": "https://doi.org/10.1523/JNEUROSCI.1949-10.2010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20739546"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20739546"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Kumar N Alagramam, Richard J Goodyear, Ruishuang Geng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0019183"}], "href": "https://doi.org/10.1371/journal.pone.0019183"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21532990"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21532990"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Shehnaaz S M Manji, Kerry A Miller, Louise H Williams, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An ENU-induced mutation of Cdh23 causes congenital hearing loss, but no vestibular dysfunction, in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2011.04.002"}], "href": "https://doi.org/10.1016/j.ajpath.2011.04.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21689626"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21689626"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Kelly L Kane, Chantal M Longo-Guess, Leona H Gagnon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hear Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.heares.2011.11.007"}], "href": "https://doi.org/10.1016/j.heares.2011.11.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22138310"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22138310"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Siwei Liu, Shengli Li, Hongliang Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A mutation in the cdh23 gene causes age-related hearing loss in Cdh23(nmf308/nmf308) mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2012.01.084"}], "href": "https://doi.org/10.1016/j.gene.2012.01.084"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22326520"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22326520"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Marisa Zallocchi, Daniel T Meehan, Duane Delimont, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role for a novel Usher protein complex in hair cell synaptic maturation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0030573"}], "href": "https://doi.org/10.1371/journal.pone.0030573"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22363448"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22363448"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Marcos Sotomayor, Wilhelm A Weihofen, Rachelle Gaudet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature11590"}], "href": "https://doi.org/10.1038/nature11590"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23135401"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23135401"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Claire J Watson, Bruce L Tempel "}, {"type": "b", "children": [{"type": "t", "text": "A new Atp2b2 deafwaddler allele, dfw(i5), interacts strongly with Cdh23 and other auditory modifiers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hear Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.heares.2013.06.003"}], "href": "https://doi.org/10.1016/j.heares.2013.06.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23792079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23792079"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Yuki Miyasaka, Sari Suzuki, Yasuhiro Ohshiba, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Compound heterozygosity of the functionally null Cdh23(v-ngt) and hypomorphic Cdh23(ahl) alleles leads to early-onset progressive hearing loss in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Anim (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1538/expanim.62.333"}], "href": "https://doi.org/10.1538/expanim.62.333"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24172198"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24172198"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "J Hu, M Xu, J Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tauroursodeoxycholic acid prevents hearing loss and hair cell death in Cdh23(erl/erl) mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroscience (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuroscience.2015.12.050"}], "href": "https://doi.org/10.1016/j.neuroscience.2015.12.050"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26748055"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26748055"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Bruce E Mock, Sarath Vijayakumar, Jessica Pierce, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential effects of Cdh23(753A) on auditory and vestibular functional aging in C57BL/6J mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Aging (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neurobiolaging.2016.03.013"}], "href": "https://doi.org/10.1016/j.neurobiolaging.2016.03.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27255811"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27255811"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Kenneth R Johnson, Cong Tian, Leona H Gagnon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effects of Cdh23 single nucleotide substitutions on age-related hearing loss in C57BL/6 and 129S1/Sv mice and comparisons with congenic strains."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep44450"}], "href": "https://doi.org/10.1038/srep44450"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28287619"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28287619"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Baptiste Libé-Philippot, Vincent Michel, Jacques Boutet de Monvel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Auditory cortex interneuron development requires cadherins operating hair-cell mechanoelectrical transduction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1703408114"}], "href": "https://doi.org/10.1073/pnas.1703408114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28705869"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28705869"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Deepanshu Choudhary, Anusha Kumar, Thomas J Magliery, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Using thermal scanning assays to test protein-protein interactions of inner-ear cadherins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0189546"}], "href": "https://doi.org/10.1371/journal.pone.0189546"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29261728"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29261728"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Mengmeng Zhao, Ping Li, Yi Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recombinant protein of the first two ectodomains of cadherin 23 from erl mice shows impairment in Ca"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "2+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "-dependent proteolysis protection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Protein Expr Purif (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.pep.2018.02.009"}], "href": "https://doi.org/10.1016/j.pep.2018.02.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29486248"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29486248"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Alice L Burghard, Nazli P Morel, Douglas L Oliver "}, {"type": "b", "children": [{"type": "t", "text": "Mice heterozygous for the Cdh23/Ahl1 mutation show age-related deficits in auditory temporal processing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Aging (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neurobiolaging.2019.02.029"}], "href": "https://doi.org/10.1016/j.neurobiolaging.2019.02.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31247458"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31247458"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Nana Li, Haibo Du, Rui Ren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alternative Splicing of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Cdh23"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Exon 68 Is Regulated by RBM24, RBM38, and PTBP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neural Plast (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/8898811"}], "href": "https://doi.org/10.1155/2020/8898811"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32774357"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32774357"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Tong Zhao, Peng Ma, Fangfang Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phenotypic differences in the inner ears of CBA/CaJ and C57BL/6J mice carrying missense and single base pair deletion mutations in the Cdh23 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jnr.24905"}], "href": "https://doi.org/10.1002/jnr.24905"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34133797"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34133797"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Xiang Yi Kong, Camilla Huse, Kuan Yang, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Endonuclease V"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Regulates Atherosclerosis Through C-C Motif Chemokine Ligand 2-Mediated Monocyte Infiltration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Heart Assoc (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/JAHA.120.020656"}], "href": "https://doi.org/10.1161/JAHA.120.020656"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34259011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34259011"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Sherylanne Newton, Fanbo Kong, Adam J Carlton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1009937"}], "href": "https://doi.org/10.1371/journal.pgen.1009937"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35100259"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35100259"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Xuehan Hou, Shumpei P Yasuda, Midori Yamaguchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Impacts of an age-related hearing loss allele of cadherin 23 on severity of hearing loss in ICR and NOD/Shi mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2023.07.003"}], "href": "https://doi.org/10.1016/j.bbrc.2023.07.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37419036"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37419036"}]}]}]}