{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have implicated ZNF503 antisense RNA 1 (ZNF503‐AS1), a long non-coding RNA, in the regulation of Ca²⁺ homeostasis and tumor suppression in bladder cancer. Specifically, evidence indicates that ZNF503‐AS1 may act as a tumor‐suppressing factor by modulating intracellular calcium levels that are critical for cell proliferation and apoptosis, suggesting a protective role in bladder carcinogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn parallel, ZNF503‐AS1 has been shown to play an important role in retinal pigment epithelium differentiation, with significant implications in diabetic retinopathy. Elevated plasma levels of ZNF503‐AS1 are correlated with a higher incidence of diabetic retinopathy, and its overexpression has been found to inhibit cell proliferation, promote apoptosis, and upregulate transforming growth factor beta 1 (TGF‑β1), thereby activating the TGF‑β signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Haiqing He, Shuiqing Wu, Kai Ai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA ZNF503-AS1 acts as a tumor suppressor in bladder cancer by up-regulating Ca"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "2+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " concentration via transcription factor GATA6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Oncol (Dordr) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13402-020-00563-z"}], "href": "https://doi.org/10.1007/s13402-020-00563-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33001357"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33001357"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ting Han, Wenrui Li, Hanrong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of long non-coding RNA ZNF503 antisense RNA 1 in diabetic retinopathy and its possible underlying mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2062988"}], "href": "https://doi.org/10.1080/21655979.2022.2062988"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35734878"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35734878"}]}]}]}