| HGNC Family | Zinc fingers |
| Name | zinc finger protein 594 |
| Description | Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn the liver, insulin‐like growth factor binding protein‑1 (IGFBP1) emerges as a pivotal survival factor that limits hepatocyte apoptosis and supports regenerative signaling. In models of acute and toxic liver injury, IGFBP1 deficiency accentuates caspase activation and cell death by enhancing pro‐apoptotic signaling cascades—including integrin‐mediated activation of MMP‑9 and subsequent TGF‑β induction—while restoration of IGFBP1 normalizes these responses. Moreover, p53‐induced IGFBP1 not only elevates its transcription but also, once partially localized to the mitochondria, binds to the pro‑apoptotic protein BAK to restrain its oligomerization and apoptotic function. In settings of developmental inhibition of pathways such as EGNL1/PHD2 in the placenta, induced IGFBP1 expression correlates with embryopathic changes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its hepatic roles, IGFBP1 critically modulates the skeleton and adipose tissue dynamics. In bone, IGFBP1—through its RGD motif—binds integrin receptors on osteoclast precursors, enhancing RANKL‐stimulated signaling that drives osteoclast differentiation and bone resorption. Conversely, in adipose‐lineage cells, IGFBP1 interacts with membrane‐associated proteins (such as dlk1) to influence the bioavailability of IGF‑1, thereby modulating adipogenic potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRegulatory control of IGFBP1 spans nutritional, hormonal, and transcriptional levels in diverse physiological and pathological contexts. Amino acid deprivation triggers both transcriptional activation and mRNA stabilization of IGFBP1, while its overexpression in the fetal liver is linked to fetal growth restriction. Nuclear receptors such as PPARs, as well as factors including HBP1 and p53, directly regulate IGFBP1 gene transcription. In pancreatic islets, IGFBP1 exerts dual actions by suppressing insulin secretion in isolated beta‑cells yet amplifying it in intact islets—likely via modulation of paracrine somatostatin release—thereby implicating IGFBP1 in glucohomeostasis. In addition, IGFBP1 levels are modulated during starvation and re‑feeding, in diabetic states (where agents like carnosine lower its expression through HIF‑1α suppression), and even in hormone‑responsive cancers, where its altered expression may affect both cellular proliferation and metabolic homeostasis. Finally, in the context of cancer metastasis, secreted IGFBP1 supports tumor cell survival under spatial confinement by enhancing mitochondrial ROS detoxification."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Julia I Leu, Mary Ann S Crissey, Rebecca Taub "}, {"type": "b", "children": [{"type": "t", "text": "Massive hepatic apoptosis associated with TGF-beta1 activation after Fas ligand treatment of IGF binding protein-1-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI16712"}], "href": "https://doi.org/10.1172/JCI16712"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12511596"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12511596"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Julia I Leu, Mary Ann S Crissey, Linden E Craig, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Impaired hepatocyte DNA synthetic response posthepatectomy in insulin-like growth factor binding protein 1-deficient mice with defects in C/EBP beta and mitogen-activated protein kinase/extracellular signal-regulated kinase regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.23.4.1251-1259.2003"}], "href": "https://doi.org/10.1128/MCB.23.4.1251-1259.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12556485"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12556485"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "J I-Ju Leu, Donna L George "}, {"type": "b", "children": [{"type": "t", "text": "Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.1567107"}], "href": "https://doi.org/10.1101/gad.1567107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18056423"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18056423"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Terence R S Ozolins, Timothy S Fisher, Diane M Nadeau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Defects in embryonic development of EGLN1/PHD2 knockdown transgenic mice are associated with induction of Igfbp in the placenta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2009.08.057"}], "href": "https://doi.org/10.1016/j.bbrc.2009.08.057"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19683511"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19683511"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "María-Luisa Nueda, José Javier García-Ramírez, Jorge Laborda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "dlk1 specifically interacts with insulin-like growth factor binding protein 1 to modulate adipogenesis of 3T3-L1 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2008.03.070"}], "href": "https://doi.org/10.1016/j.jmb.2008.03.070"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18466921"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18466921"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xunde Wang, Wei Wei, Jing Y Krzeszinski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2015.09.010"}], "href": "https://doi.org/10.1016/j.cmet.2015.09.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26456333"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26456333"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Julien Averous, Anne-Catherine Maurin, Alain Bruhat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Induction of IGFBP-1 expression by amino acid deprivation of HepG2 human hepatoma cells involves both a transcriptional activation and an mRNA stabilization due to its 3'UTR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2005.03.077"}], "href": "https://doi.org/10.1016/j.febslet.2005.03.077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15862298"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15862298"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Carole S Watson, Peter Bialek, Makoto Anzo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated circulating insulin-like growth factor binding protein-1 is sufficient to cause fetal growth restriction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2005-0606"}], "href": "https://doi.org/10.1210/en.2005-0606"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16293667"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16293667"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Tatjana Degenhardt, Merja Matilainen, Karl-Heinz Herzig, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The insulin-like growth factor-binding protein 1 gene is a primary target of peroxisome proliferator-activated receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M605623200"}], "href": "https://doi.org/10.1074/jbc.M605623200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17062566"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17062566"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Fan Zhang, Åke Sjöholm, Qimin Zhang "}, {"type": "b", "children": [{"type": "t", "text": "Attenuation of insulin secretion by insulin-like growth factor binding protein-1 in pancreatic beta-cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2007.07.160"}], "href": "https://doi.org/10.1016/j.bbrc.2007.07.160"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17693389"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17693389"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Keiichi Minami, Miki Nakajima, Yuto Fujiki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of insulin-like growth factor binding protein-1 and lipoprotein lipase by the aryl hydrocarbon receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Toxicol Sci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2131/jts.33.405"}], "href": "https://doi.org/10.2131/jts.33.405"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18827440"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18827440"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Ashley Gray, William J Aronson, R James Barnard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Global Igfbp1 deletion does not affect prostate cancer development in a c-Myc transgenic mouse model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Endocrinol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/JOE-11-0240"}], "href": "https://doi.org/10.1530/JOE-11-0240"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21903863"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21903863"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Wen-Ying Shen, Gang Ren, Yao-Rong Zhu "}, {"type": "b", "children": [{"type": "t", "text": "[Effects of compensatory growth on the levels of IGF-1, IGFBP-1 and expressions of IGF-1 mRNA, IGF-1R mRNA in Carassius auratus gibelio]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dongwuxue Yanjiu (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3724/SP.J.1141.2012.03298"}], "href": "https://doi.org/10.3724/SP.J.1141.2012.03298"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22653858"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22653858"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Elisabete A Forsberg, Ileana R Botusan, Jing Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Carnosine decreases IGFBP1 production in db/db mice through suppression of HIF-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Endocrinol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/JOE-14-0571"}], "href": "https://doi.org/10.1530/JOE-14-0571"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25869614"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25869614"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yuning Cheng, Ruixiang Yang, Yue Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HBP1 inhibits the development of type 2 diabetes mellitus through transcriptional activation of the "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "IGFBP1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.204364"}], "href": "https://doi.org/10.18632/aging.204364"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36326689"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36326689"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Guoqing Cai, Yijun Qi, Ping Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IGFBP1 Sustains Cell Survival during Spatially-Confined Migration and Promotes Tumor Metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Adv Sci (Weinh) (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/advs.202206540"}], "href": "https://doi.org/10.1002/advs.202206540"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37296072"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37296072"}]}]}]}
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| Proteins | ZN594_HUMAN |
| NCBI Gene ID | 84622 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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ZNF594 has 3,457 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 73 datasets.
Click the + buttons to view associations for ZNF594 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of ZNF594 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ZNF594 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of ZNF594 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of ZNF594 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of ZNF594 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of ZNF594 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of ZNF594 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of ZNF594 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of ZNF594 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of ZNF594 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of ZNF594 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing ZNF594 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with ZNF594 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with ZNF594 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Chemical Interactions | chemicals interacting with ZNF594 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
| CTD Gene-Disease Associations | diseases associated with ZNF594 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of ZNF594 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by ZNF594 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with ZNF594 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at ZNF594 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of ZNF594 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of ZNF594 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing ZNF594 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of ZNF594 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of ZNF594 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of ZNF594 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of ZNF594 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of ZNF594 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of ZNF594 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving ZNF594 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving ZNF594 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing ZNF594 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing ZNF594 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by ZNF594 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by ZNF594 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of ZNF594 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of ZNF594 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ZNF594 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of ZNF594 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with ZNF594 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with ZNF594 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of ZNF594 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of ZNF594 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of ZNF594 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ZNF594 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for ZNF594 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of ZNF594 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of ZNF594 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Kinase Library Serine Threonine Kinome Atlas | kinases that phosphorylate ZNF594 protein from the Kinase Library Serine Threonine Atlas dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of ZNF594 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of ZNF594 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with ZNF594 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of ZNF594 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing ZNF594 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain ZNF594 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting ZNF594 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of ZNF594 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| NURSA Protein Complexes | protein complexs containing ZNF594 protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for ZNF594 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of ZNF594 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of ZNF594 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at ZNF594 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of ZNF594 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of ZNF594 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of ZNF594 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Sci-Plex Drug Perturbation Signatures | drug perturbations changing expression of ZNF594 gene from the Sci-Plex Drug Perturbation Signatures dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of ZNF594 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of ZNF594 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of ZNF594 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of ZNF594 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of ZNF594 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of ZNF594 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with ZNF594 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
