{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA review of the provided studies reveals an extensive body of work on the functions of ETS family transcription factors—most notably ER81 (also known as ETV1) and its paralogs—in diverse processes such as neuronal differentiation, synaptic connectivity, electrophysiological properties of the heart, branching morphogenesis, and oncogenic transformation. For example, several studies document how NT3‐dependent ER81 induction regulates proper sensory–motor connectivity in the spinal cord"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", while others highlight ER81/ETV1’s role in specifying neuronal subtype identity in the cortex"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "and in fine‐tuning fast conduction properties in cardiac tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional abstracts elucidate how these transcription factors integrate extracellular signals (e.g., FGF, TGF‑β/SMAD, BDNF) to modulate downstream gene networks that drive cellular maturation in the nervous system"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", contribute to the development of mechanoreceptors"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", and even affect tumor initiation and progression in prostate and gastrointestinal cancers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " In parallel, studies on other factors such as Annexin A8 have expanded our understanding of cellular differentiation in non-neural tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDespite the breadth of data detailed across these publications, a careful examination of the abstracts indicates that none address or even mention ZNF705G. In other words, while the literature richly characterizes the regulatory roles of ETS transcription factors and other mediators in development, physiology, and disease, no functional information regarding ZNF705G is provided. Thus, based on these studies, the biological role—or any contribution—of ZNF705G remains undefined, highlighting a gap to be filled by future research.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCitations:."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "13"}, {"type": "fg_f", "ref": "11"}, {"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "14"}, {"type": "fg_f", "ref": "12"}, {"type": "fg_f", "ref": "15"}, {"type": "fg_f", "ref": "3"}, {"type": "fg_fs", "start_ref": "17", "end_ref": "20"}, {"type": "fg_f", "ref": "5"}, {"type": "fg_f", "ref": "21"}, {"type": "fg_f", "ref": "9"}, {"type": "fg_fs", "start_ref": "22", "end_ref": "26"}, {"type": "fg_f", "ref": "7"}, {"type": "fg_f", "ref": "4"}, {"type": "fg_fs", "start_ref": "27", "end_ref": "30"}, {"type": "fg_f", "ref": "10"}, {"type": "fg_fs", "start_ref": "31", "end_ref": "34"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tushar D Patel, Ina Kramer, Jan Kucera, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Peripheral NT3 signaling is required for ETS protein expression and central patterning of proprioceptive sensory afferents."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuron (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0896-6273(03)00261-7"}], "href": "https://doi.org/10.1016/s0896-6273(03"}, {"type": "t", "text": "00261-7) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12741988"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12741988"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "H Yoneshima, S Yamasaki, C C J Voelker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Er81 is expressed in a subpopulation of layer 5 neurons in rodent and primate neocortices."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroscience (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuroscience.2005.08.075"}], "href": "https://doi.org/10.1016/j.neuroscience.2005.08.075"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16289830"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16289830"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tran Cong Tuoc, Anastassia Stoykova "}, {"type": "b", "children": [{"type": "t", "text": "Er81 is a downstream target of Pax6 in cortical progenitors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Dev Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-213X-8-23"}], "href": "https://doi.org/10.1186/1471-213X-8-23"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18307776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18307776"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Akshay Shekhar, Xianming Lin, Fang-Yu Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcription factor ETV1 is essential for rapid conduction in the heart."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI87968"}], "href": "https://doi.org/10.1172/JCI87968"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27775552"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27775552"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Haruka Abe, Makoto Okazawa, Shigetada Nakanishi "}, {"type": "b", "children": [{"type": "t", "text": "The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1109940108"}], "href": "https://doi.org/10.1073/pnas.1109940108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21746923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21746923"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Makoto Okazawa, Haruka Abe, Shigetada Nakanishi "}, {"type": "b", "children": [{"type": "t", "text": "The Etv1 transcription factor activity-dependently downregulates a set of genes controlling cell growth and differentiation in maturing cerebellar granule cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2016.04.017"}], "href": "https://doi.org/10.1016/j.bbrc.2016.04.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27059140"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27059140"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Michael S Fleming, Jian J Li, Daniel Ramos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A RET-ER81-NRG1 Signaling Pathway Drives the Development of Pacinian Corpuscles."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.2160-16.2016"}], "href": "https://doi.org/10.1523/JNEUROSCI.2160-16.2016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27707970"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27707970"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "J Sedý, S Tseng, J M Walro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ETS transcription factor ER81 is required for the Pacinian corpuscle development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Dyn (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dvdy.20710"}], "href": "https://doi.org/10.1002/dvdy.20710"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16493690"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16493690"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Esther Baena, Zhen Shao, Douglas E Linn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.211011.112"}], "href": "https://doi.org/10.1101/gad.211011.112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23512661"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23512661"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Sangphil Oh, Sook Shin, Hoogeun Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Relationship between ETS Transcription Factor ETV1 and TGF-β-regulated SMAD Proteins in Prostate Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-44685-3"}], "href": "https://doi.org/10.1038/s41598-019-44685-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31160676"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31160676"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Torsten Stein, Karen N Price, Joanna S Morris, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-05-0547"}], "href": "https://doi.org/10.1158/1078-0432.CCR-05-0547"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16203777"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16203777"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Fabian Runkel, Marion Michels, Sebastian Franken, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Specific expression of annexin A8 in adult murine stratified epithelia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Histol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10735-006-9063-4"}], "href": "https://doi.org/10.1007/s10735-006-9063-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17082908"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17082908"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Anne Chotteau-Lelievre, Roberto Montesano, Jesus Soriano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PEA3 transcription factors are expressed in tissues undergoing branching morphogenesis and promote formation of duct-like structures by mammary epithelial cells in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0012-1606(03)00182-9"}], "href": "https://doi.org/10.1016/s0012-1606(03"}, {"type": "t", "text": "00182-9) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12871699"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12871699"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "L Y Li, Z Wang, J Sedý, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neurotrophin-3 ameliorates sensory-motor deficits in Er81-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Dyn (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dvdy.20964"}], "href": "https://doi.org/10.1002/dvdy.20964"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17013886"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17013886"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Sachiko Saino-Saito, John W Cave, Yosuke Akiba, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ER81 and CaMKIV identify anatomically and phenotypically defined subsets of mouse olfactory bulb interneurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Comp Neurol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cne.21293"}], "href": "https://doi.org/10.1002/cne.21293"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17394138"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17394138"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Guoying Wang, Sheryl A Scott "}, {"type": "b", "children": [{"type": "t", "text": "Onset of ETS expression is not accelerated by premature exposure to signals from limb mesenchyme."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Dyn (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dvdy.21236"}], "href": "https://doi.org/10.1002/dvdy.21236"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17654714"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17654714"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Marten P Smidt, J Peter H Burbach "}, {"type": "b", "children": [{"type": "t", "text": "A passport to neurotransmitter identity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/gb-2009-10-7-229"}], "href": "https://doi.org/10.1186/gb-2009-10-7-229"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19591649"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19591649"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "John W Cave, Yosuke Akiba, Kasturi Banerjee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential regulation of dopaminergic gene expression by Er81."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.0419-10.2010"}], "href": "https://doi.org/10.1523/JNEUROSCI.0419-10.2010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20357122"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20357122"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Tania N Crotti, Regina P O'Sullivan, Zhenxin Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bone matrix regulates osteoclast differentiation and annexin A8 gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.22699"}], "href": "https://doi.org/10.1002/jcp.22699"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21344395"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21344395"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Lionel Budry, Catherine Couture, Aurélio Balsalobre, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Ets factor Etv1 interacts with Tpit protein for pituitary pro-opiomelanocortin (POMC) gene transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.202788"}], "href": "https://doi.org/10.1074/jbc.M110.202788"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21622576"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21622576"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Haruka Abe, Makoto Okazawa, Shigetada Nakanishi "}, {"type": "b", "children": [{"type": "t", "text": "Gene regulation via excitation and BDNF is mediated by induction and phosphorylation of the Etv1 transcription factor in cerebellar granule cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1206418109"}], "href": "https://doi.org/10.1073/pnas.1206418109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22586091"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22586091"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Yo-Ichi Yamamoto-Shiraishi, Hiroaki Higuchi, Shigeki Yamamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Etv1 and Ewsr1 cooperatively regulate limb mesenchymal Fgf10 expression in response to apical ectodermal ridge-derived fibroblast growth factor signal."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2014.07.022"}], "href": "https://doi.org/10.1016/j.ydbio.2014.07.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25109552"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25109552"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Juan Manuel Iglesias, Claire J Cairney, Roderick K Ferrier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Annexin A8 identifies a subpopulation of transiently quiescent c-kit positive luminal progenitor cells of the ductal mammary epithelium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0119718"}], "href": "https://doi.org/10.1371/journal.pone.0119718"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25803307"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25803307"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Yujiro Hayashi, Michael R Bardsley, Yoshitaka Toyomasu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Platelet-Derived Growth Factor Receptor-α Regulates Proliferation of Gastrointestinal Stromal Tumor Cells With Mutations in KIT by Stabilizing ETV1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2015.04.006"}], "href": "https://doi.org/10.1053/j.gastro.2015.04.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25865047"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25865047"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Nathalie Dehorter, Gabriele Ciceri, Giorgia Bartolini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tuning of fast-spiking interneuron properties by an activity-dependent transcriptional switch."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.aab3415"}], "href": "https://doi.org/10.1126/science.aab3415"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26359400"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26359400"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Tae-Dong Kim, Fang Jin, Sook Shin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI78132"}], "href": "https://doi.org/10.1172/JCI78132"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26731476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26731476"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Yu-Chien Kao, Yun-Shao Sung, Chun-Liang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ETV transcriptional upregulation is more reliable than RNA sequencing algorithms and FISH in diagnosing round cell sarcomas with CIC gene rearrangements."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Chromosomes Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/gcc.22454"}], "href": "https://doi.org/10.1002/gcc.22454"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28233365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28233365"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Leili Ran, Devan Murphy, Jessica Sher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ETV1-Positive Cells Give Rise to "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "BRAF"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "V600E"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " -Mutant Gastrointestinal Stromal Tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-16-3510"}], "href": "https://doi.org/10.1158/0008-5472.CAN-16-3510"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28539323"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28539323"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Carolin Rommel, Stephan Rösner, Achim Lother, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Transcription Factor ETV1 Induces Atrial Remodeling and Arrhythmia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.118.313036"}], "href": "https://doi.org/10.1161/CIRCRESAHA.118.313036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29930145"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29930145"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Akshay Shekhar, Xianming Lin, Bin Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ETV1 activates a rapid conduction transcriptional program in rodent and human cardiomyocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-28239-7"}], "href": "https://doi.org/10.1038/s41598-018-28239-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29967479"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29967479"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Alan P Tenney, Jean Livet, Timothy Belton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Etv1 Controls the Establishment of Non-overlapping Motor Innervation of Neighboring Facial Muscles during Development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2019.08.078"}], "href": "https://doi.org/10.1016/j.celrep.2019.08.078"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31597102"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31597102"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Ankur Garg, Abdul Hannan, Qian Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Etv transcription factors functionally diverge from their upstream FGF signaling in lens development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.51915"}], "href": "https://doi.org/10.7554/eLife.51915"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32043969"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32043969"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Noorya Yasmin Ahmed, Yadollah Ranjbar-Slamloo, Alice Shaam Al Abed, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Er81 Transcription Factor Fine-Tunes Striatal Cholinergic Interneuron Activity and Drives Habit Formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.0967-20.2021"}], "href": "https://doi.org/10.1523/JNEUROSCI.0967-20.2021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33849945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33849945"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Makoto Ohmoto, Masafumi Jyotaki, Karen K Yee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Transcription Factor Etv1/Er81 Is Involved in the Differentiation of Sweet, Umami, and Sodium Taste Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "eNeuro (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/ENEURO.0236-22.2023"}], "href": "https://doi.org/10.1523/ENEURO.0236-22.2023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37045597"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37045597"}]}]}]}