{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that ZNF711, an X‐linked zinc finger protein, plays an important role in neurodevelopment by interacting with epigenetic regulators. Notably, ZNF711 associates with the histone demethylase PHF8 to target key genes involved in brain function, thereby implicating this factor in X‐linked mental retardation (20346720."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, down regulation of ZNF711 has been linked to cisplatin resistance in epithelial ovarian cancer, suggesting that its expression level can fundamentally impact cellular responses to chemotherapy (34521054."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Family‐based studies have further established that mutations in ZNF711 are associated with non‐syndromic intellectual disability characterized by mild to moderate cognitive impairment and speech deficits (27993705."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nComplementary functional experiments have demonstrated that ZNF711 is a critical transcription regulator; CRISPR‐mediated knockouts in human cells reveal that loss of ZNF711, together with related zinc finger proteins, leads to widespread alterations in gene expression and impaired cell proliferation (32406922."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, its participation in a network of syntenic X‐chromosomal factors—including ARX, PHF8, and KDM5C—further corroborates its role in orchestrating epigenetic and transcriptional pathways during brain development (34356104."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In addition, investigations into protein–protein interactions have shown that ZNF711 is stabilized via its interaction with KCTD5, emphasizing an additional layer of regulation at the post‐translational level (26188516."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, comprehensive genetic analyses in multiple families affected by intellectual disability have reinforced the significance of ZNF711 mutations in neurodevelopmental disorders, with affected males often exhibiting autistic features alongside cognitive deficits (21384559."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " A distinct ZNF711‐specific methylation signature has also been identified, offering a novel biomarker to confirm the pathogenicity of variants in this gene (34992252."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Daniela Kleine-Kohlbrecher, Jesper Christensen, Julien Vandamme, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "ZNF711 down-regulation promotes CISPLATIN resistance in epithelial ovarian cancer via interacting with JHDM2A and suppressing SLC31A1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EBioMedicine (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ebiom.2021.103558"}], "href": "https://doi.org/10.1016/j.ebiom.2021.103558"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34521054"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34521054"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ilse M van der Werf, Anke Van Dijck, Edwin Reyniers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in two large pedigrees highlight the role of ZNF711 in X-linked intellectual disability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2016.12.013"}], "href": "https://doi.org/10.1016/j.gene.2016.12.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27993705"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27993705"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Weiya Ni, Andrew A Perez, Shannon Schreiner, et al. 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