SH2 domain containing Gene Family

HGNC Family ID 741

Genes

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
BCAR3 breast cancer anti-estrogen resistance 3
BLK BLK proto-oncogene, Src family tyrosine kinase
BLNK B-cell linker
BMX BMX non-receptor tyrosine kinase
BTK Bruton agammaglobulinemia tyrosine kinase
CHN1 chimerin 1
CHN2 chimerin 2
CISH cytokine inducible SH2-containing protein
CLNK cytokine-dependent hematopoietic cell linker
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSK c-src tyrosine kinase
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
FER fer (fps/fes related) tyrosine kinase
FES FES proto-oncogene, tyrosine kinase
FGR FGR proto-oncogene, Src family tyrosine kinase
FRK fyn-related Src family tyrosine kinase
FYN FYN proto-oncogene, Src family tyrosine kinase
GRAP GRB2-related adaptor protein
GRAP2 GRB2-related adaptor protein 2
GRAPL GRB2-related adaptor protein-like
GRB10 growth factor receptor-bound protein 10
GRB14 growth factor receptor-bound protein 14
GRB2 growth factor receptor-bound protein 2
GRB7 growth factor receptor-bound protein 7
HCK HCK proto-oncogene, Src family tyrosine kinase
HSH2D hematopoietic SH2 domain containing
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
INPPL1 inositol polyphosphate phosphatase-like 1
ITK IL2-inducible T-cell kinase
JAK2 Janus kinase 2
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LYN LYN proto-oncogene, Src family tyrosine kinase
MATK megakaryocyte-associated tyrosine kinase
NCK1 NCK adaptor protein 1
NCK2 NCK adaptor protein 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PTK6 protein tyrosine kinase 6
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RASA1 RAS p21 protein activator (GTPase activating protein) 1
SH2B1 SH2B adaptor protein 1
SH2B2 SH2B adaptor protein 2
SH2B3 SH2B adaptor protein 3
SH2D1A SH2 domain containing 1A
SH2D1B SH2 domain containing 1B
SH2D2A SH2 domain containing 2A
SH2D3A SH2 domain containing 3A
SH2D3C SH2 domain containing 3C
SH2D4A SH2 domain containing 4A
SH2D4B SH2 domain containing 4B
SH2D6 SH2 domain containing 6
SH2D7 SH2 domain containing 7
SH3BP2 SH3-domain binding protein 2
SHB Src homology 2 domain containing adaptor protein B
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC2 SHC (Src homology 2 domain containing) transforming protein 2
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SHC4 SHC (Src homology 2 domain containing) family, member 4
SHD Src homology 2 domain containing transforming protein D
SHE Src homology 2 domain containing E
SHF Src homology 2 domain containing F
SLA Src-like-adaptor
SLA2 Src-like-adaptor 2
SOCS1 suppressor of cytokine signaling 1
SOCS2 suppressor of cytokine signaling 2
SOCS3 suppressor of cytokine signaling 3
SOCS4 suppressor of cytokine signaling 4
SOCS5 suppressor of cytokine signaling 5
SOCS6 suppressor of cytokine signaling 6
SOCS7 suppressor of cytokine signaling 7
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
STAP1 signal transducing adaptor family member 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
SYK spleen tyrosine kinase
TEC tec protein tyrosine kinase
TNS1 tensin 1
TNS2 tensin 2
TNS3 tensin 3
TNS4 tensin 4
TXK TXK tyrosine kinase
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
YES1 YES proto-oncogene 1, Src family tyrosine kinase
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa