(4-Chlorobenzyl)pyridine Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/78124
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Genes

199 proteins with high or low expression in (4-Chlorobenzyl)pyridine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
VAV1 vav 1 guanine nucleotide exchange factor 1.56
USP6NL USP6 N-terminal like 1.5
TTLL4 tubulin tyrosine ligase-like family member 4 1.43
MYT1 myelin transcription factor 1 1.22
EPHA1 EPH receptor A1 1.2
MTUS2 microtubule associated tumor suppressor candidate 2 1.08
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 1.05
NEK4 NIMA-related kinase 4 0.94
MARCHF7 membrane associated ring-CH-type finger 7 0.94
TPM1 tropomyosin 1 (alpha) 0.87
ADPRH ADP-ribosylarginine hydrolase 0.85
HPCAL4 hippocalcin like 4 0.8
ACTBL2 actin, beta-like 2 0.76
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.73
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae) 0.72
DTX3L deltex 3 like, E3 ubiquitin ligase 0.65
SLC26A2 solute carrier family 26 (anion exchanger), member 2 0.65
KMT2B lysine (K)-specific methyltransferase 2B 0.64
SREBF2 sterol regulatory element binding transcription factor 2 0.63
TRAM2 translocation associated membrane protein 2 0.6
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 0.59
CHD6 chromodomain helicase DNA binding protein 6 0.58
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 0.58
PIP prolactin-induced protein 0.56
ALG6 ALG6, alpha-1,3-glucosyltransferase 0.52
SLF2 SMC5-SMC6 complex localization factor 2 0.51
AASDH aminoadipate-semialdehyde dehydrogenase 0.51
CAPN15 calpain 15 0.51
UEVLD UEV and lactate/malate dehyrogenase domains 0.5
MT-CO1 cytochrome c oxidase subunit I 0.5
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 0.49
SIK2 salt-inducible kinase 2 0.49
MADD MAP-kinase activating death domain 0.49
BBS1 Bardet-Biedl syndrome 1 0.49
TMCO3 transmembrane and coiled-coil domains 3 0.49
RINL Ras and Rab interactor-like 0.48
ARHGAP44 Rho GTPase activating protein 44 0.48
DEPDC1B DEP domain containing 1B 0.48
ZNF516 zinc finger protein 516 0.48
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 0.47
IFNGR1 interferon gamma receptor 1 0.47
RBKS ribokinase 0.47
C6ORF47 chromosome 6 open reading frame 47 0.46
ZNF440 zinc finger protein 440 0.46
RBSN rabenosyn, RAB effector 0.46
ELAC1 elaC ribonuclease Z 1 0.46
ZUP1 zinc finger containing ubiquitin peptidase 1 0.45
ACTR3B ARP3 actin-related protein 3 homolog B (yeast) 0.44
LAMA3 laminin, alpha 3 0.44
MATR3 matrin 3 0.43
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.43
AZGP1 alpha-2-glycoprotein 1, zinc-binding 0.43
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 0.43
COMMD7 COMM domain containing 7 0.43
WNT10B wingless-type MMTV integration site family, member 10B 0.43
VSNL1 visinin-like 1 0.43
PDLIM3 PDZ and LIM domain 3 0.42
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.42
CREG1 cellular repressor of E1A-stimulated genes 1 0.42
LATS2 large tumor suppressor kinase 2 0.42
CTSH cathepsin H 0.42
LAMA1 laminin, alpha 1 0.41
KIAA0586 KIAA0586 0.41
FGD1 FYVE, RhoGEF and PH domain containing 1 0.41
RPUSD3 RNA pseudouridylate synthase domain containing 3 0.41
CLCN3 chloride channel, voltage-sensitive 3 0.41
STK11 serine/threonine kinase 11 0.4
ZNF428 zinc finger protein 428 0.4
DTX2 deltex 2, E3 ubiquitin ligase 0.4
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.4
CDK11A cyclin-dependent kinase 11A 0.4
IQGAP2 IQ motif containing GTPase activating protein 2 0.4
KDM4C lysine (K)-specific demethylase 4C 0.4
PRPF40B PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) 0.39
DUSP6 dual specificity phosphatase 6 0.39
POU2F1 POU class 2 homeobox 1 0.39
CMC1 C-x(9)-C motif containing 1 0.39
MERTK MER proto-oncogene, tyrosine kinase 0.39
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.39
NALCN sodium leak channel, non selective 0.39
PUM1 pumilio RNA-binding family member 1 0.39
TRO trophinin 0.39
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.38
HPS3 Hermansky-Pudlak syndrome 3 0.37
ARHGAP42 Rho GTPase activating protein 42 0.37
ANKRD10 ankyrin repeat domain 10 0.37
KIAA0100 KIAA0100 0.37
UBXN2A UBX domain protein 2A 0.37
MT-ATP6 ATP synthase F0 subunit 6 0.36
SOCS2 suppressor of cytokine signaling 2 0.36
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.36
STX1A syntaxin 1A (brain) 0.36
TMEM246 transmembrane protein 246 0.36
OGFRL1 opioid growth factor receptor-like 1 0.36
TMEM260 transmembrane protein 260 0.36
PTPRE protein tyrosine phosphatase, receptor type, E 0.36
EMP3 epithelial membrane protein 3 0.36
NEIL1 nei endonuclease VIII-like 1 (E. coli) 0.36
ABAT 4-aminobutyrate aminotransferase 0.35
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 0.35

low expression

Symbol Name Standardized Value
PTPRK protein tyrosine phosphatase, receptor type, K -1.19
KLHL21 kelch-like family member 21 -0.89
MED18 mediator complex subunit 18 -0.85
TRPM1 transient receptor potential cation channel, subfamily M, member 1 -0.83
OTC ornithine carbamoyltransferase -0.74
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase -0.71
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B -0.7
COA6 cytochrome c oxidase assembly factor 6 -0.7
TMEM222 transmembrane protein 222 -0.69
VEZF1 vascular endothelial zinc finger 1 -0.68
ZNF483 zinc finger protein 483 -0.67
FN1 fibronectin 1 -0.65
SRD5A3 steroid 5 alpha-reductase 3 -0.63
PRELID3B PRELI domain containing 3B -0.62
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 -0.62
SSR1 signal sequence receptor, alpha -0.61
AMZ2 archaelysin family metallopeptidase 2 -0.59
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) -0.58
PARL presenilin associated, rhomboid-like -0.58
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa -0.56
KSR1 kinase suppressor of ras 1 -0.56
LAPTM4A lysosomal protein transmembrane 4 alpha -0.56
MDK midkine (neurite growth-promoting factor 2) -0.56
COL14A1 collagen, type XIV, alpha 1 -0.56
EMC8 ER membrane protein complex subunit 8 -0.55
HOXA10 homeobox A10 -0.54
AVEN apoptosis, caspase activation inhibitor -0.53
AURKAIP1 aurora kinase A interacting protein 1 -0.53
FLCN folliculin -0.53
BRI3BP BRI3 binding protein -0.53
TUBA1C tubulin, alpha 1c -0.53
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.53
XDH xanthine dehydrogenase -0.52
ZNF169 zinc finger protein 169 -0.52
CETN1 centrin, EF-hand protein, 1 -0.52
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 -0.51
NECTIN2 nectin cell adhesion molecule 2 -0.51
SEPHS2 selenophosphate synthetase 2 -0.5
BTG3 BTG family, member 3 -0.5
MBNL2 muscleblind-like splicing regulator 2 -0.48
SLC22A18 solute carrier family 22, member 18 -0.48
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -0.47
CCDC77 coiled-coil domain containing 77 -0.47
MICOS10 mitochondrial contact site and cristae organizing system subunit 10 -0.46
PCSK6 proprotein convertase subtilisin/kexin type 6 -0.46
AMD1 adenosylmethionine decarboxylase 1 -0.46
RPL35 ribosomal protein L35 -0.46
RSL24D1 ribosomal L24 domain containing 1 -0.45
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.45
FUBP1 far upstream element (FUSE) binding protein 1 -0.45
CEP112 centrosomal protein 112kDa -0.44
FSIP2 fibrous sheath interacting protein 2 -0.41
MFSD5 major facilitator superfamily domain containing 5 -0.41
PTGES prostaglandin E synthase -0.41
SPIDR scaffolding protein involved in DNA repair -0.41
MT1L metallothionein 1L (gene/pseudogene) -0.41
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon -0.41
UFC1 ubiquitin-fold modifier conjugating enzyme 1 -0.41
RPL37 ribosomal protein L37 -0.41
CEP57 centrosomal protein 57kDa -0.41
MTA1 metastasis associated 1 -0.4
SMN1 survival of motor neuron 1, telomeric -0.4
MT2A metallothionein 2A -0.4
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A -0.39
CFL1 cofilin 1 (non-muscle) -0.39
CEP152 centrosomal protein 152kDa -0.39
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow -0.39
LLPH LLP homolog, long-term synaptic facilitation (Aplysia) -0.39
ABITRAM actin binding transcription modulator -0.38
AIF1L allograft inflammatory factor 1-like -0.38
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 -0.38
MT1X metallothionein 1X -0.37
YTHDC1 YTH domain containing 1 -0.37
TMCO1 transmembrane and coiled-coil domains 1 -0.37
PABPN1 poly(A) binding protein, nuclear 1 -0.37
ERGIC3 ERGIC and golgi 3 -0.37
MRPS18C mitochondrial ribosomal protein S18C -0.36
HMGN3 high mobility group nucleosomal binding domain 3 -0.36
ANKRD16 ankyrin repeat domain 16 -0.36
RAB8B RAB8B, member RAS oncogene family -0.36
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.36
RPS8 ribosomal protein S8 -0.35
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.35
TMEM33 transmembrane protein 33 -0.35
EMC3 ER membrane protein complex subunit 3 -0.35
SPATA2L spermatogenesis associated 2-like -0.35
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit -0.35
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -0.35
GK glycerol kinase -0.35
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa -0.35
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 -0.35
MAZ MYC-associated zinc finger protein (purine-binding transcription factor) -0.35
NEK6 NIMA-related kinase 6 -0.35
CNTROB centrobin, centrosomal BRCA2 interacting protein -0.35
RPL32 ribosomal protein L32 -0.35
DNM1L dynamin 1-like -0.34
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5 -0.34
H1-2 H1.2 linker histone, cluster member -0.34
KIAA1586 KIAA1586 -0.34