(R)-Verapamil (hydrochloride)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (R)-Verapamil (hydrochloride) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the (R)-Verapamil (hydrochloride)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0698543
SMAD3 SMAD family member 3 0.0629048
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0610792
NRIP1 nuclear receptor interacting protein 1 0.0587351
MYH9 myosin, heavy chain 9, non-muscle 0.0551098
NRP2 neuropilin 2 0.0549426
NAV2 neuron navigator 2 0.052611
EXT1 exostosin glycosyltransferase 1 0.0510413
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0483773
TXNRD1 thioredoxin reductase 1 0.0475938
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0463436
TRIO trio Rho guanine nucleotide exchange factor 0.0454383
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0442218
RPS4X ribosomal protein S4, X-linked 0.042349
CSF1 colony stimulating factor 1 (macrophage) 0.0420122
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0409654
ANKRD33B ankyrin repeat domain 33B 0.0406596
JAK1 Janus kinase 1 0.0401507
APP amyloid beta (A4) precursor protein 0.0395145
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0392903
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0343505
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0326645
SEPTIN9 septin 9 0.0315048
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0312572
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0301449
SHB Src homology 2 domain containing adaptor protein B 0.0296289
SPAG9 sperm associated antigen 9 0.0279933
MBNL2 muscleblind-like splicing regulator 2 0.0257994
CXCL8 chemokine (C-X-C motif) ligand 8 0.0256329
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0250462
ARRDC3 arrestin domain containing 3 0.0246322
PAX8 paired box 8 0.024181
ADAM17 ADAM metallopeptidase domain 17 0.0241167
MSR1 macrophage scavenger receptor 1 0.0238944
FNDC3B fibronectin type III domain containing 3B 0.0235219
RNF213 ring finger protein 213 0.0234035
RUNX1 runt-related transcription factor 1 0.0230384
CREB5 cAMP responsive element binding protein 5 0.0227677
ANXA5 annexin A5 0.0225819
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.0221714
PDLIM5 PDZ and LIM domain 5 0.0219479
ERRFI1 ERBB receptor feedback inhibitor 1 0.0215827
MORF4L2 mortality factor 4 like 2 0.0215674
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0214014
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0208954
DOCK5 dedicator of cytokinesis 5 0.0207713
ICAM1 intercellular adhesion molecule 1 0.0206426
TNRC6A trinucleotide repeat containing 6A 0.0203583
NFE2L1 nuclear factor, erythroid 2-like 1 0.02023
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0202283
ACTN1 actinin, alpha 1 0.0198207
ARHGAP26 Rho GTPase activating protein 26 0.0198134
HDAC9 histone deacetylase 9 0.0198087
AFF1 AF4/FMR2 family, member 1 0.0193767
CTBP2 C-terminal binding protein 2 0.0193751
TUFT1 tuftelin 1 0.0193261
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0190469
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0184609
IRS2 insulin receptor substrate 2 0.0181673
MBNL1 muscleblind-like splicing regulator 1 0.0180997
ACTN4 actinin, alpha 4 0.0180901
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0179832
FMNL2 formin-like 2 0.0179305
WAC WW domain containing adaptor with coiled-coil 0.0178679
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0177727
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0176144
ANXA1 annexin A1 0.0173774
IFI44L interferon-induced protein 44-like 0.0173045
ATF3 activating transcription factor 3 0.0167157
TLE4 transducin-like enhancer of split 4 0.0165126
ECPAS Ecm29 proteasome adaptor and scaffold 0.016494
CHD1 chromodomain helicase DNA binding protein 1 0.0162802
TOB1 transducer of ERBB2, 1 0.0162393
DDIT4 DNA-damage-inducible transcript 4 0.0159276
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0158862
UBE2H ubiquitin-conjugating enzyme E2H 0.0155795
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0153954
SOX9 SRY (sex determining region Y)-box 9 0.0153867
NDRG1 N-myc downstream regulated 1 0.0153803
UBA6 ubiquitin-like modifier activating enzyme 6 0.0153521
RPS2 ribosomal protein S2 0.0153398
XPO1 exportin 1 0.0152525
NIBAN1 niban apoptosis regulator 1 0.0152041
TUT7 terminal uridylyl transferase 7 0.0151152
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0150763
FXR1 fragile X mental retardation, autosomal homolog 1 0.014896
BCL2L1 BCL2-like 1 0.0148596
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0148445
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0148139
ZMIZ1 zinc finger, MIZ-type containing 1 0.0147526
FLNB filamin B, beta 0.0145599
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0145207
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.014403
USP12 ubiquitin specific peptidase 12 0.0143987
MB21D2 Mab-21 domain containing 2 0.0143745
NFE2L2 nuclear factor, erythroid 2-like 2 0.0143672
NCKAP1 NCK-associated protein 1 0.0142956
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0141564
KTN1 kinectin 1 (kinesin receptor) 0.0141221
TSC22D2 TSC22 domain family, member 2 0.01412

decreased expression

Symbol Name Standardized Value
FRMD4A FERM domain containing 4A -0.230849
VIM vimentin -0.163747
GPC6 glypican 6 -0.107295
TMSB10 thymosin beta 10 -0.0959138
CP ceruloplasmin (ferroxidase) -0.0947454
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0706408
TPT1 tumor protein, translationally-controlled 1 -0.0706181
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0699223
HLA-B major histocompatibility complex, class I, B -0.0683657
FTL ferritin, light polypeptide -0.0677547
IGFBP3 insulin-like growth factor binding protein 3 -0.0618528
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0590789
RPL35A ribosomal protein L35a -0.0587294
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0582611
PTMA prothymosin, alpha -0.0579661
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0550796
CTSD cathepsin D -0.0507211
RAI14 retinoic acid induced 14 -0.0500323
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0484027
CAVIN1 caveolae associated protein 1 -0.0483637
TPM4 tropomyosin 4 -0.047002
ASPH aspartate beta-hydroxylase -0.0468857
APOL1 apolipoprotein L, 1 -0.0458414
PLIN2 perilipin 2 -0.0449928
ACTG1 actin gamma 1 -0.0437148
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0434082
RPS24 ribosomal protein S24 -0.041827
ANXA4 annexin A4 -0.0413545
EIF1 eukaryotic translation initiation factor 1 -0.0411388
RPL34 ribosomal protein L34 -0.0406582
FN1 fibronectin 1 -0.0403628
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0380242
TSHZ2 teashirt zinc finger homeobox 2 -0.0379185
RPS6 ribosomal protein S6 -0.0379008
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0376453
PDE4D phosphodiesterase 4D, cAMP-specific -0.036952
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0344096
SPDYA speedy/RINGO cell cycle regulator family member A -0.0342698
TPM1 tropomyosin 1 (alpha) -0.0341333
CALD1 caldesmon 1 -0.0340114
RPS13 ribosomal protein S13 -0.0335882
OXR1 oxidation resistance 1 -0.0334221
EHBP1 EH domain binding protein 1 -0.0333411
S100A6 S100 calcium binding protein A6 -0.0330578
PRKCA protein kinase C, alpha -0.032814
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0327273
RPL31 ribosomal protein L31 -0.0326715
HSPB1 heat shock 27kDa protein 1 -0.0325934
TTC3 tetratricopeptide repeat domain 3 -0.0325848
SCFD2 sec1 family domain containing 2 -0.0319975
UBC ubiquitin C -0.0317976
RPS27A ribosomal protein S27a -0.0309278
GCC2 GRIP and coiled-coil domain containing 2 -0.0307214
MTDH metadherin -0.0305505
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0303657
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0303507
CUX1 cut-like homeobox 1 -0.0301451
RPS8 ribosomal protein S8 -0.0300705
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0294141
ZBTB20 zinc finger and BTB domain containing 20 -0.0293838
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0293789
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0293448
MAP1B microtubule-associated protein 1B -0.0282323
HLA-C major histocompatibility complex, class I, C -0.0281901
B2M beta-2-microglobulin -0.0281387
HLA-E major histocompatibility complex, class I, E -0.0280575
ARL4C ADP-ribosylation factor-like 4C -0.0276217
POTEF POTE ankyrin domain family, member F -0.0270043
MRPS6 mitochondrial ribosomal protein S6 -0.0269335
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0262157
VCL vinculin -0.0261379
GLIS3 GLIS family zinc finger 3 -0.0260463
RPL19 ribosomal protein L19 -0.0260052
VDAC1 voltage-dependent anion channel 1 -0.0259797
TMEM263 transmembrane protein 263 -0.0258655
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0256753
RHEX regulator of hemoglobinization and erythroid cell expansion -0.0250393
TM4SF1 transmembrane 4 L six family member 1 -0.0247656
RPLP2 ribosomal protein, large, P2 -0.0246244
CMIP c-Maf inducing protein -0.0245732
RRBP1 ribosome binding protein 1 -0.0244131
ZMYND8 zinc finger, MYND-type containing 8 -0.0243829
RPL7A ribosomal protein L7a -0.0242849
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0240493
KPNB1 karyopherin (importin) beta 1 -0.0238624
CLMP CXADR-like membrane protein -0.0236434
CD63 CD63 molecule -0.0235569
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 -0.0233232
MON2 MON2 homolog (S. cerevisiae) -0.0233225
COL8A1 collagen, type VIII, alpha 1 -0.0231266
CALR calreticulin -0.0229632
LOC112694756 uncharaterized LOC112694756 -0.0229197
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0226461
GNAS GNAS complex locus -0.0218438
RPS21 ribosomal protein S21 -0.0218136
CD82 CD82 molecule -0.0217875
LIMA1 LIM domain and actin binding 1 -0.0217806
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0217219
LAMB3 laminin, beta 3 -0.0216434
RPL9 ribosomal protein L9 -0.0216293