(R)-Verapamil (hydrochloride)_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (R)-Verapamil (hydrochloride) perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the (R)-Verapamil (hydrochloride)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NRIP1 nuclear receptor interacting protein 1 0.0699901
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0642964
MT2A metallothionein 2A 0.0571321
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.05593
MCL1 myeloid cell leukemia 1 0.0557973
ARHGAP26 Rho GTPase activating protein 26 0.0552156
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0501465
FLNB filamin B, beta 0.0496894
THSD4 thrombospondin, type I, domain containing 4 0.0469159
RPS4X ribosomal protein S4, X-linked 0.0466617
DOCK5 dedicator of cytokinesis 5 0.0450431
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0449031
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0440207
RPL23 ribosomal protein L23 0.0424711
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0420446
RPS12 ribosomal protein S12 0.0416033
NPAS2 neuronal PAS domain protein 2 0.0407681
RPS19 ribosomal protein S19 0.0389307
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0380606
RPS3 ribosomal protein S3 0.0375857
RPL37A ribosomal protein L37a 0.037538
RPS17 ribosomal protein S17 0.0359783
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0341073
EGFR epidermal growth factor receptor 0.0332393
EPAS1 endothelial PAS domain protein 1 0.0332363
SMYD3 SET and MYND domain containing 3 0.0313112
PDE4D phosphodiesterase 4D, cAMP-specific 0.0305792
RPL26 ribosomal protein L26 0.0289326
BCL2L1 BCL2-like 1 0.0287761
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0278434
ERRFI1 ERBB receptor feedback inhibitor 1 0.0275504
ANGPTL4 angiopoietin-like 4 0.0268012
RPL18 ribosomal protein L18 0.0254334
PRRC2C proline-rich coiled-coil 2C 0.025053
SHB Src homology 2 domain containing adaptor protein B 0.0247922
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0243703
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0236323
ZSWIM6 zinc finger, SWIM-type containing 6 0.0230773
WWOX WW domain containing oxidoreductase 0.0229414
FAT1 FAT atypical cadherin 1 0.0225228
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0224849
CMIP c-Maf inducing protein 0.022395
RUNX1 runt-related transcription factor 1 0.0208904
AKAP13 A kinase (PRKA) anchor protein 13 0.0206057
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0200325
RPL31 ribosomal protein L31 0.0198505
ATXN1 ataxin 1 0.0195518
SAMD4A sterile alpha motif domain containing 4A 0.0189503
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0187966
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.018575
BPTF bromodomain PHD finger transcription factor 0.0184444
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0181168
BMP6 bone morphogenetic protein 6 0.0180568
NDRG1 N-myc downstream regulated 1 0.017879
RPS8 ribosomal protein S8 0.0177431
RPL36 ribosomal protein L36 0.0176964
VEGFC vascular endothelial growth factor C 0.0176174
RPL5 ribosomal protein L5 0.0174451
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0172881
HMGA2 high mobility group AT-hook 2 0.0170294
ITPRID2 ITPR interacting domain containing 2 0.0169274
PTPRF protein tyrosine phosphatase, receptor type, F 0.0168499
MINK1 misshapen-like kinase 1 0.0167826
AHR aryl hydrocarbon receptor 0.0167724
USP47 ubiquitin specific peptidase 47 0.0166535
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.0165533
ERBIN erbb2 interacting protein 0.0164618
ABTB3 ankyrin repeat and BTB domain containing 3 0.0161548
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0161486
DSCAM Down syndrome cell adhesion molecule 0.0161433
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 0.0161371
FLNA filamin A, alpha 0.0158311
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.015809
RPS2 ribosomal protein S2 0.0157891
SLC35F3 solute carrier family 35, member F3 0.0157004
RPS11 ribosomal protein S11 0.0155924
RPS29 ribosomal protein S29 0.0153399
EFNA5 ephrin-A5 0.0151311
KANK1 KN motif and ankyrin repeat domains 1 0.0151267
KDM7A lysine (K)-specific demethylase 7A 0.0150682
UBASH3B ubiquitin associated and SH3 domain containing B 0.0150123
ZC3H12C zinc finger CCCH-type containing 12C 0.0149478
RAD51B RAD51 paralog B 0.0149156
RBBP6 retinoblastoma binding protein 6 0.0148522
TGM2 transglutaminase 2 0.0148155
MPRIP myosin phosphatase Rho interacting protein 0.0147214
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0146767
SEPTIN9 septin 9 0.0146025
RIMKLB ribosomal modification protein rimK-like family member B 0.014536
MBNL1 muscleblind-like splicing regulator 1 0.0144617
TGFBR1 transforming growth factor, beta receptor 1 0.0144061
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0143852
RPL9 ribosomal protein L9 0.0143385
CEMIP2 cell migration inducing hyaluronidase 2 0.0143338
NHSL1 NHS-like 1 0.014058
SLC38A2 solute carrier family 38, member 2 0.0140363
GPATCH2L G patch domain containing 2-like 0.0139902
FOXP1 forkhead box P1 0.01393
TRAPPC9 trafficking protein particle complex 9 0.0138311
GRAMD1B GRAM domain containing 1B 0.0137118

decreased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.190297
ANXA2 annexin A2 -0.162312
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.161434
FTH1 ferritin, heavy polypeptide 1 -0.149955
AKAP12 A kinase (PRKA) anchor protein 12 -0.145095
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.102772
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.100129
FTL ferritin, light polypeptide -0.0943112
USP3 ubiquitin specific peptidase 3 -0.0880772
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0847
IGFBP3 insulin-like growth factor binding protein 3 -0.0843806
SOD2 superoxide dismutase 2, mitochondrial -0.0804076
ACTG1 actin gamma 1 -0.0798783
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0760837
PGK1 phosphoglycerate kinase 1 -0.0723053
AKR1C2 aldo-keto reductase family 1, member C2 -0.0708946
AHNAK AHNAK nucleoprotein -0.069677
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0643905
NAMPT nicotinamide phosphoribosyltransferase -0.0639097
KCTD9 potassium channel tetramerization domain containing 9 -0.063645
GOLGA4 golgin A4 -0.0630885
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0626829
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0609981
CANX calnexin -0.0609163
PTMA prothymosin, alpha -0.0583381
PKM pyruvate kinase, muscle -0.0567917
CA12 carbonic anhydrase XII -0.0558087
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0557189
UBC ubiquitin C -0.0546548
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0536892
S100A6 S100 calcium binding protein A6 -0.053574
KDM3A lysine (K)-specific demethylase 3A -0.0532983
RAB1A RAB1A, member RAS oncogene family -0.0528364
LDHA lactate dehydrogenase A -0.051829
TPM4 tropomyosin 4 -0.0516886
LOC112694756 uncharaterized LOC112694756 -0.0512015
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0487816
RRBP1 ribosome binding protein 1 -0.0483134
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0481949
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0479781
HELZ helicase with zinc finger -0.0467096
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0438119
VCL vinculin -0.0433827
SPAG9 sperm associated antigen 9 -0.0432003
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0430384
IGFBP4 insulin-like growth factor binding protein 4 -0.0429235
MAP1B microtubule-associated protein 1B -0.0426339
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0425578
HDLBP high density lipoprotein binding protein -0.040596
TKT transketolase -0.0399395
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0398053
CLINT1 clathrin interactor 1 -0.0397753
POTEF POTE ankyrin domain family, member F -0.0393928
RIGI RNA sensor RIG-I -0.0389971
RPS6 ribosomal protein S6 -0.0386969
VDAC1 voltage-dependent anion channel 1 -0.0383089
NCOA7 nuclear receptor coactivator 7 -0.0378229
EIF1 eukaryotic translation initiation factor 1 -0.0370612
SETD5 SET domain containing 5 -0.0370582
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0363984
OSMR oncostatin M receptor -0.0358713
TMSB4X thymosin beta 4, X-linked -0.0357491
LMAN1 lectin, mannose-binding, 1 -0.0356468
RPL4 ribosomal protein L4 -0.0356209
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0355162
RNF213 ring finger protein 213 -0.0353025
COPB1 coatomer protein complex, subunit beta 1 -0.0346344
KPNB1 karyopherin (importin) beta 1 -0.0345028
SRP54 signal recognition particle 54kDa -0.0343749
SLC38A1 solute carrier family 38, member 1 -0.0339222
ADAM9 ADAM metallopeptidase domain 9 -0.0337447
ARL5B ADP-ribosylation factor-like 5B -0.0336879
BZW1 basic leucine zipper and W2 domains 1 -0.0336471
RTN4 reticulon 4 -0.0335369
RPLP0 ribosomal protein, large, P0 -0.0335292
BHLHE40 basic helix-loop-helix family, member e40 -0.0331173
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0327717
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0326961
FNDC3B fibronectin type III domain containing 3B -0.0326702
NPEPPS aminopeptidase puromycin sensitive -0.0317559
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0314611
ENO1 enolase 1, (alpha) -0.0312521
H1-0 H1.0 linker histone -0.0309219
KRT81 keratin 81, type II -0.0307199
HIP1 huntingtin interacting protein 1 -0.0306988
WDR45B WD repeat domain 45B -0.0304567
RBM39 RNA binding motif protein 39 -0.0304312
ANKRD11 ankyrin repeat domain 11 -0.0301966
SP100 SP100 nuclear antigen -0.0300203
TMEM263 transmembrane protein 263 -0.0299054
ADAM17 ADAM metallopeptidase domain 17 -0.0297914
MON2 MON2 homolog (S. cerevisiae) -0.0296272
RAB2A RAB2A, member RAS oncogene family -0.0295761
ATG7 autophagy related 7 -0.0293153
SBF2 SET binding factor 2 -0.029234
RAI14 retinoic acid induced 14 -0.0289869
ACBD3 acyl-CoA binding domain containing 3 -0.0289346
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0287108
DENND4C DENN/MADD domain containing 4C -0.0286134
ARF1 ADP-ribosylation factor 1 -0.0285585