(R)-Verapamil (hydrochloride)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (R)-Verapamil (hydrochloride) perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the (R)-Verapamil (hydrochloride)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.201497
RPS4X ribosomal protein S4, X-linked 0.0699052
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0627644
PCM1 pericentriolar material 1 0.0598452
PRELID2 PRELI domain containing 2 0.0555295
AKAP9 A kinase (PRKA) anchor protein 9 0.051997
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0473496
FNIP1 folliculin interacting protein 1 0.0472741
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0462463
SMYD3 SET and MYND domain containing 3 0.044992
VEGFA vascular endothelial growth factor A 0.0448436
TSHZ2 teashirt zinc finger homeobox 2 0.0443573
KMT2C lysine (K)-specific methyltransferase 2C 0.0413038
NFIB nuclear factor I/B 0.0412369
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0402395
ZFAND3 zinc finger, AN1-type domain 3 0.039925
ZNF608 zinc finger protein 608 0.0399247
ZNF292 zinc finger protein 292 0.0393223
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.0376394
PRRC2C proline-rich coiled-coil 2C 0.0373468
FER fer (fps/fes related) tyrosine kinase 0.0346507
PHF21A PHD finger protein 21A 0.0342115
PCBP2 poly(rC) binding protein 2 0.032933
MXI1 MAX interactor 1, dimerization protein 0.0315712
CDK19 cyclin-dependent kinase 19 0.0314605
GPHN gephyrin 0.0312041
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.0311519
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0310596
SFTPA2 surfactant protein A2 0.0307286
KIAA1328 KIAA1328 0.0306878
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0304199
TBC1D5 TBC1 domain family, member 5 0.0303978
PRKN parkin RBR E3 ubiquitin protein ligase 0.0303809
FBXL7 F-box and leucine-rich repeat protein 7 0.0303642
PRKG1 protein kinase, cGMP-dependent, type I 0.0303638
DMXL1 Dmx-like 1 0.0302988
PHIP pleckstrin homology domain interacting protein 0.0298582
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0296094
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0290975
THSD4 thrombospondin, type I, domain containing 4 0.0288008
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.0286394
ARID1A AT rich interactive domain 1A (SWI-like) 0.0286201
EP300 E1A binding protein p300 0.0283879
GSE1 Gse1 coiled-coil protein 0.0275894
RSRC1 arginine/serine-rich coiled-coil 1 0.027586
HOXA3 homeobox A3 0.0275617
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0274729
PDE4B phosphodiesterase 4B, cAMP-specific 0.0272202
NAMPT nicotinamide phosphoribosyltransferase 0.0268415
PHF3 PHD finger protein 3 0.0267718
ZEB1 zinc finger E-box binding homeobox 1 0.0259391
ZNF516 zinc finger protein 516 0.0259179
KAZN kazrin, periplakin interacting protein 0.025906
TNRC6B trinucleotide repeat containing 6B 0.0258568
SEC24B SEC24 family member B 0.0254274
BOC BOC cell adhesion associated, oncogene regulated 0.0254205
SLK STE20-like kinase 0.0253564
PDGFC platelet derived growth factor C 0.025242
UBTD2 ubiquitin domain containing 2 0.0250693
UST uronyl-2-sulfotransferase 0.0247008
TOP2B topoisomerase (DNA) II beta 180kDa 0.0246103
CAMTA1 calmodulin binding transcription activator 1 0.0245977
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0245097
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0243899
SPAG9 sperm associated antigen 9 0.0238571
SCAF8 SR-related CTD-associated factor 8 0.023816
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0234765
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0232958
ARRDC3 arrestin domain containing 3 0.0231884
DBN1 drebrin 1 0.0229958
ARHGAP21 Rho GTPase activating protein 21 0.0229756
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0228591
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0227646
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0226901
MAP2K4 mitogen-activated protein kinase kinase 4 0.0224142
RPS2 ribosomal protein S2 0.0221274
NCOR1 nuclear receptor corepressor 1 0.0220696
FNDC3B fibronectin type III domain containing 3B 0.0220551
GYS1 glycogen synthase 1 (muscle) 0.021642
SCAF11 SR-related CTD-associated factor 11 0.021343
ADAM10 ADAM metallopeptidase domain 10 0.0213129
SMAP1 small ArfGAP 1 0.0212785
RNF150 ring finger protein 150 0.0210013
ANKRD12 ankyrin repeat domain 12 0.0209254
EXT1 exostosin glycosyltransferase 1 0.0209095
UBAP2L ubiquitin associated protein 2-like 0.0207473
EXOC6B exocyst complex component 6B 0.0204962
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0204429
GPBP1 GC-rich promoter binding protein 1 0.0203669
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.020302
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0202788
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.0202689
THOC2 THO complex 2 0.0202102
MORF4L2 mortality factor 4 like 2 0.0201056
EXOC4 exocyst complex component 4 0.0200709
HOXC6 homeobox C6 0.019987
ARB2A ARB2 cotranscriptional regulator A 0.0197669
KDM6A lysine (K)-specific demethylase 6A 0.0197211
KDM7A lysine (K)-specific demethylase 7A 0.0197195
NOTCH2 notch 2 0.0197118

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.180518
PTMA prothymosin, alpha -0.151823
PEG10 paternally expressed 10 -0.138653
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.131113
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.122132
MEST mesoderm specific transcript -0.119402
RPL35A ribosomal protein L35a -0.0883434
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0770656
ACTG1 actin gamma 1 -0.0765945
TMSB10 thymosin beta 10 -0.0736557
RPS25 ribosomal protein S25 -0.0656008
MGP matrix Gla protein -0.0630974
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0601471
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0596064
RPLP0 ribosomal protein, large, P0 -0.0575904
PDIA3 protein disulfide isomerase family A, member 3 -0.0526633
KPNB1 karyopherin (importin) beta 1 -0.0525028
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0522808
TPM4 tropomyosin 4 -0.0522542
DEK DEK proto-oncogene -0.0510345
LOC112694756 uncharaterized LOC112694756 -0.0480207
RPS6 ribosomal protein S6 -0.0478795
COL1A2 collagen, type I, alpha 2 -0.0474578
RPL34 ribosomal protein L34 -0.0464281
NDRG1 N-myc downstream regulated 1 -0.0448458
FTL ferritin, light polypeptide -0.0446168
RPLP1 ribosomal protein, large, P1 -0.0443147
FOXC1 forkhead box C1 -0.0441788
RAB7A RAB7A, member RAS oncogene family -0.0438614
DLG1 discs, large homolog 1 (Drosophila) -0.0436122
RPLP2 ribosomal protein, large, P2 -0.0434133
MAP1B microtubule-associated protein 1B -0.0430974
RPS24 ribosomal protein S24 -0.0407891
RPS8 ribosomal protein S8 -0.0398905
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0398009
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0387418
RPL37 ribosomal protein L37 -0.0387097
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0386793
PGK1 phosphoglycerate kinase 1 -0.0383266
HMGA1 high mobility group AT-hook 1 -0.0379897
RANBP17 RAN binding protein 17 -0.0377901
MARCHF6 membrane associated ring-CH-type finger 6 -0.0371278
RPS13 ribosomal protein S13 -0.0365036
ANXA2 annexin A2 -0.0364426
RPS20 ribosomal protein S20 -0.0361991
TPT1 tumor protein, translationally-controlled 1 -0.035877
SEPTIN11 septin 11 -0.034222
POTEF POTE ankyrin domain family, member F -0.0340296
RPL19 ribosomal protein L19 -0.0336541
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0333519
RPL7A ribosomal protein L7a -0.0333009
RSU1 Ras suppressor protein 1 -0.0332724
VDAC1 voltage-dependent anion channel 1 -0.0330584
KDM5B lysine (K)-specific demethylase 5B -0.0329741
CANX calnexin -0.0329035
PTK2 protein tyrosine kinase 2 -0.0328802
SERBP1 SERPINE1 mRNA binding protein 1 -0.032576
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0318768
RPL31 ribosomal protein L31 -0.0317569
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0317195
DSTN destrin (actin depolymerizing factor) -0.0313626
RAN RAN, member RAS oncogene family -0.0313536
RPS16 ribosomal protein S16 -0.0311191
LARS1 leucyl-tRNA synthetase 1 -0.0308951
SLC38A2 solute carrier family 38, member 2 -0.0308535
TMSB4X thymosin beta 4, X-linked -0.0303737
CADM2 cell adhesion molecule 2 -0.0303337
SLC38A1 solute carrier family 38, member 1 -0.0300787
EIF1 eukaryotic translation initiation factor 1 -0.03005
HMGB1 high mobility group box 1 -0.0294284
IARS1 isoleucyl-tRNA synthetase 1 -0.0292457
IER3 immediate early response 3 -0.0289718
PFN1 profilin 1 -0.0284062
TPK1 thiamin pyrophosphokinase 1 -0.0282282
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0277663
RPS21 ribosomal protein S21 -0.0277592
NAP1L1 nucleosome assembly protein 1-like 1 -0.0275953
TBCA tubulin folding cofactor A -0.0272128
SOX4 SRY (sex determining region Y)-box 4 -0.0271469
ENO1 enolase 1, (alpha) -0.0270741
SRRM2 serine/arginine repetitive matrix 2 -0.0270545
RPS27A ribosomal protein S27a -0.0268643
GNAS GNAS complex locus -0.0267935
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0267765
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0265932
VCL vinculin -0.0265712
PKM pyruvate kinase, muscle -0.0263605
TTC3 tetratricopeptide repeat domain 3 -0.0262715
MTDH metadherin -0.0260209
BSG basigin (Ok blood group) -0.0257506
COTL1 coactosin-like F-actin binding protein 1 -0.0252465
MT2A metallothionein 2A -0.0251912
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0248967
CLMP CXADR-like membrane protein -0.0246388
EIF5B eukaryotic translation initiation factor 5B -0.0246271
RSL1D1 ribosomal L1 domain containing 1 -0.0245738
SEC31A SEC31 homolog A (S. cerevisiae) -0.024535
RPL15 ribosomal protein L15 -0.0244223
HSPB1 heat shock 27kDa protein 1 -0.0243311
PCNX4 pecanex 4 -0.0241328