(R)-Verapamil (hydrochloride)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (R)-Verapamil (hydrochloride) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the (R)-Verapamil (hydrochloride)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
JMJD1C jumonji domain containing 1C 0.0661564
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0630041
VCL vinculin 0.0627238
RPS4X ribosomal protein S4, X-linked 0.0580412
RPL23 ribosomal protein L23 0.0514969
USP34 ubiquitin specific peptidase 34 0.0509483
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0500144
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0455972
RPS12 ribosomal protein S12 0.0452173
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0441705
KMT2C lysine (K)-specific methyltransferase 2C 0.0400686
JARID2 jumonji, AT rich interactive domain 2 0.0391534
PRRC2C proline-rich coiled-coil 2C 0.0385634
ZNF608 zinc finger protein 608 0.0374757
COL5A2 collagen, type V, alpha 2 0.0365293
RPS3 ribosomal protein S3 0.036317
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0357367
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0354773
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0348054
PCM1 pericentriolar material 1 0.0343616
VMP1 vacuole membrane protein 1 0.0330073
PNN pinin, desmosome associated protein 0.0327508
HHIP hedgehog interacting protein 0.0326612
RCC1 regulator of chromosome condensation 1 0.031708
HELZ helicase with zinc finger 0.0316999
ELF2 E74-like factor 2 (ets domain transcription factor) 0.031667
DST dystonin 0.0316426
ASPH aspartate beta-hydroxylase 0.0313798
AKAP9 A kinase (PRKA) anchor protein 9 0.0312008
SYAP1 synapse associated protein 1 0.0311437
INTS6 integrator complex subunit 6 0.0308168
PCBP2 poly(rC) binding protein 2 0.0305219
MBNL1 muscleblind-like splicing regulator 1 0.0298031
JUN jun proto-oncogene 0.0294464
MCL1 myeloid cell leukemia 1 0.028577
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.028425
CREBBP CREB binding protein 0.027806
FAM193A family with sequence similarity 193, member A 0.0271652
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0270882
APLP2 amyloid beta (A4) precursor-like protein 2 0.0267611
FNDC3B fibronectin type III domain containing 3B 0.0265138
ZSWIM6 zinc finger, SWIM-type containing 6 0.0264064
UBAP2 ubiquitin associated protein 2 0.0262912
VIM vimentin 0.0262222
FERMT2 fermitin family member 2 0.0255513
PCNX4 pecanex 4 0.0252991
NBEAL1 neurobeachin-like 1 0.0241996
KDM6A lysine (K)-specific demethylase 6A 0.0241504
NALF1 NALCN channel auxiliary factor 1 0.0240067
RPS8 ribosomal protein S8 0.0238504
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0237698
ANKRD17 ankyrin repeat domain 17 0.023541
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0232207
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0230237
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0229058
RPL5 ribosomal protein L5 0.0227934
BPTF bromodomain PHD finger transcription factor 0.0227265
DSCAM Down syndrome cell adhesion molecule 0.0227046
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.022655
CENPE centromere protein E, 312kDa 0.0226168
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.02251
RUNX1 runt-related transcription factor 1 0.0223711
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0223467
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0222417
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0222322
PDS5B PDS5 cohesin associated factor B 0.0222072
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0218903
CAPZB capping protein (actin filament) muscle Z-line, beta 0.021863
FBXL20 F-box and leucine-rich repeat protein 20 0.0218488
MORF4L2 mortality factor 4 like 2 0.0216618
ATXN2 ataxin 2 0.0215386
SPAG9 sperm associated antigen 9 0.0212159
SNX14 sorting nexin 14 0.0212157
TTC19 tetratricopeptide repeat domain 19 0.0212153
ATP9A ATPase, class II, type 9A 0.021083
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0209461
SIK3 SIK family kinase 3 0.0209325
NFIB nuclear factor I/B 0.0208948
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0207848
YBX1 Y box binding protein 1 0.0207043
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0206029
TOB2 transducer of ERBB2, 2 0.0205403
MBD5 methyl-CpG binding domain protein 5 0.0204803
MED13 mediator complex subunit 13 0.0204705
BRD2 bromodomain containing 2 0.0204267
BBX bobby sox homolog (Drosophila) 0.0204184
RPS19 ribosomal protein S19 0.0201836
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0201233
BBS9 Bardet-Biedl syndrome 9 0.0199308
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.019853
FOXP1 forkhead box P1 0.0197719
HELLS helicase, lymphoid-specific 0.0196066
LIMCH1 LIM and calponin homology domains 1 0.0194729
ARID1A AT rich interactive domain 1A (SWI-like) 0.0193559
PHF21A PHD finger protein 21A 0.019254
NF1 neurofibromin 1 0.0192485
NUP58 nucleoporin 58 0.0192395
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa 0.0191403
PNISR PNN-interacting serine/arginine-rich protein 0.0191069
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0190517

decreased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.130937
RAD51B RAD51 paralog B -0.116184
TENM3 teneurin transmembrane protein 3 -0.112195
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.101287
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0965264
NPAS3 neuronal PAS domain protein 3 -0.0946399
SLIT2 slit homolog 2 (Drosophila) -0.092861
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0894881
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0893179
ATP11A ATPase, class VI, type 11A -0.0775016
NEBL nebulette -0.0768383
ACTG1 actin gamma 1 -0.0761217
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0709719
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0676001
SHROOM3 shroom family member 3 -0.0617633
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0594394
OSBPL10 oxysterol binding protein-like 10 -0.0587972
CELF2 CUGBP, Elav-like family member 2 -0.0568922
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0499562
LOC112694756 uncharaterized LOC112694756 -0.0499351
GJA1 gap junction protein, alpha 1, 43kDa -0.0497935
SERBP1 SERPINE1 mRNA binding protein 1 -0.0464184
TRIO trio Rho guanine nucleotide exchange factor -0.0463529
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0449397
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.04463
TOX thymocyte selection-associated high mobility group box -0.043197
ARHGAP32 Rho GTPase activating protein 32 -0.0427784
LARS1 leucyl-tRNA synthetase 1 -0.0406861
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0404406
FMNL2 formin-like 2 -0.0397438
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0385346
TBC1D32 TBC1 domain family, member 32 -0.0369827
KPNB1 karyopherin (importin) beta 1 -0.0361411
VDAC1 voltage-dependent anion channel 1 -0.0349983
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0345325
RSL1D1 ribosomal L1 domain containing 1 -0.0342173
H1-0 H1.0 linker histone -0.0339208
PRICKLE1 prickle homolog 1 (Drosophila) -0.0335858
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0334468
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0333934
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0332333
NT5C2 5'-nucleotidase, cytosolic II -0.0332272
MAGEA4 melanoma antigen family A4 -0.0327254
MAP4 microtubule-associated protein 4 -0.0310723
HMGA1 high mobility group AT-hook 1 -0.0309876
SALL4 spalt-like transcription factor 4 -0.0308585
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0305407
CADM2 cell adhesion molecule 2 -0.0299795
SOX4 SRY (sex determining region Y)-box 4 -0.0298459
RPLP0 ribosomal protein, large, P0 -0.0297528
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0291809
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0291741
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0285456
PRRC2B proline-rich coiled-coil 2B -0.0284553
MCTP1 multiple C2 domains, transmembrane 1 -0.028201
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0281066
TOM1L2 target of myb1-like 2 (chicken) -0.0280109
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0269226
MDN1 MDN1, midasin homolog (yeast) -0.026478
SLF1 SMC5-SMC6 complex localization factor 1 -0.0264015
WDR43 WD repeat domain 43 -0.0263874
GAB2 GRB2-associated binding protein 2 -0.0263518
HACD3 3-hydroxyacyl-CoA dehydratase 3 -0.0260976
PA2G4 proliferation-associated 2G4, 38kDa -0.0259063
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0256521
RPS27A ribosomal protein S27a -0.0256433
CAVIN1 caveolae associated protein 1 -0.0254202
ZFP64 ZFP64 zinc finger protein -0.0250683
ZNF33A zinc finger protein 33A -0.0248471
RAD21 RAD21 homolog (S. pombe) -0.0244376
IARS1 isoleucyl-tRNA synthetase 1 -0.024051
PDE4D phosphodiesterase 4D, cAMP-specific -0.024051
ANXA2 annexin A2 -0.0238332
ILF3 interleukin enhancer binding factor 3, 90kDa -0.0238214
LDHB lactate dehydrogenase B -0.0233769
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0232145
TPD52 tumor protein D52 -0.0231825
PTPRG protein tyrosine phosphatase, receptor type, G -0.0229629
PUS7 pseudouridylate synthase 7 (putative) -0.0229354
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -0.0227482
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -0.0227348
CFAP97 cilia and flagella associated protein 97 -0.022612
RPL4 ribosomal protein L4 -0.0225993
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.022541
MLIP muscular LMNA-interacting protein -0.0224736
ZNF217 zinc finger protein 217 -0.0220437
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0218861
HMGB1 high mobility group box 1 -0.0218728
SUN1 Sad1 and UNC84 domain containing 1 -0.0218612
DENND1A DENN/MADD domain containing 1A -0.0216556
KCNH7 potassium channel, voltage gated eag related subfamily H, member 7 -0.0215434
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0214931
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -0.0214916
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0214812
CHD4 chromodomain helicase DNA binding protein 4 -0.0214179
KDM1A lysine (K)-specific demethylase 1A -0.0214166
ZNF770 zinc finger protein 770 -0.0213465
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0213442
CARMIL1 capping protein regulator and myosin 1 linker 1 -0.0213302
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0212205