(R)-Verapamil (hydrochloride)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (R)-Verapamil (hydrochloride) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the (R)-Verapamil (hydrochloride)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.233622
COL6A3 collagen, type VI, alpha 3 0.0781628
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0780542
AKAP12 A kinase (PRKA) anchor protein 12 0.0778811
ERRFI1 ERBB receptor feedback inhibitor 1 0.0651879
APP amyloid beta (A4) precursor protein 0.0277983
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0267499
ASPH aspartate beta-hydroxylase 0.0259131
EGFR epidermal growth factor receptor 0.0244464
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0238768
FLNB filamin B, beta 0.0232878
CCL5 chemokine (C-C motif) ligand 5 0.0218354
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0211599
ELL2 elongation factor, RNA polymerase II, 2 0.0210119
STC1 stanniocalcin 1 0.0204813
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.018983
DGKD diacylglycerol kinase, delta 130kDa 0.0189017
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0186182
HSPA8 heat shock 70kDa protein 8 0.0185688
SMAD3 SMAD family member 3 0.0184724
ANO6 anoctamin 6 0.0178512
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0178301
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0177757
ANKRD28 ankyrin repeat domain 28 0.0177706
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0177462
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0168078
NFE2L1 nuclear factor, erythroid 2-like 1 0.0161264
PRELID2 PRELI domain containing 2 0.0160572
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.016014
MXI1 MAX interactor 1, dimerization protein 0.0155648
JUN jun proto-oncogene 0.0154488
ACTN1 actinin, alpha 1 0.0151941
WWTR1 WW domain containing transcription regulator 1 0.0150506
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.0148719
DOCK5 dedicator of cytokinesis 5 0.0148537
MYLK myosin light chain kinase 0.0147394
TSC22D1 TSC22 domain family, member 1 0.0142839
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0140671
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0140414
PTPRD protein tyrosine phosphatase, receptor type, D 0.0138209
CD44 CD44 molecule (Indian blood group) 0.0135275
UBAP2L ubiquitin associated protein 2-like 0.0133137
EMP1 epithelial membrane protein 1 0.0133073
RFX8 RFX family member 8, lacking RFX DNA binding domain 0.0131914
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0129909
DST dystonin 0.0129417
SDF4 stromal cell derived factor 4 0.0129231
MYOF myoferlin 0.0126747
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0126318
NCOA7 nuclear receptor coactivator 7 0.0125558
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0124826
RNF220 ring finger protein 220 0.0123012
SAMD4A sterile alpha motif domain containing 4A 0.0122717
NDRG1 N-myc downstream regulated 1 0.01207
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0117629
VMP1 vacuole membrane protein 1 0.0117388
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0116916
MORF4L2 mortality factor 4 like 2 0.0115639
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0115331
NONO non-POU domain containing, octamer-binding 0.0111407
CAPN2 calpain 2, (m/II) large subunit 0.0110315
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.0109332
IQGAP3 IQ motif containing GTPase activating protein 3 0.0109104
SERINC1 serine incorporator 1 0.010892
SPRED2 sprouty-related, EVH1 domain containing 2 0.0107359
PALM2AKAP2 PALM2 and AKAP2 fusion 0.010595
CUL4B cullin 4B 0.0105078
NPHP3 nephronophthisis 3 (adolescent) 0.0104052
E2F7 E2F transcription factor 7 0.0102205
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0102149
MLPH melanophilin 0.0101417
SEPTIN10 septin 10 0.00993012
C1S complement component 1, s subcomponent 0.00988199
ZBTB38 zinc finger and BTB domain containing 38 0.00982341
EIF4H eukaryotic translation initiation factor 4H 0.00980506
CORO1C coronin, actin binding protein, 1C 0.00979235
DUSP6 dual specificity phosphatase 6 0.00974202
DNMBP dynamin binding protein 0.00971151
MAST4 microtubule associated serine/threonine kinase family member 4 0.00951435
PLEC plectin 0.00950727
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.00945615
FLNA filamin A, alpha 0.0094316
ARRDC3 arrestin domain containing 3 0.00941728
ARHGAP5 Rho GTPase activating protein 5 0.00933355
YEATS2 YEATS domain containing 2 0.009323
NPC1 Niemann-Pick disease, type C1 0.00925612
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.00922722
KIAA1217 KIAA1217 0.00920287
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 0.00920065
SYNE2 spectrin repeat containing, nuclear envelope 2 0.00910293
ZC3H12B zinc finger CCCH-type containing 12B 0.00909637
BHLHE40 basic helix-loop-helix family, member e40 0.00907093
CCDC47 coiled-coil domain containing 47 0.00905991
RIMS2 regulating synaptic membrane exocytosis 2 0.00899261
CDCA7L cell division cycle associated 7-like 0.00893946
CEP152 centrosomal protein 152kDa 0.00888575
ANKRD36 ankyrin repeat domain 36 0.00887907
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.00884973
AMPD3 adenosine monophosphate deaminase 3 0.00879937
FNBP1L formin binding protein 1-like 0.00874241

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.230005
TMSB10 thymosin beta 10 -0.204933
FTL ferritin, light polypeptide -0.170689
VIM vimentin -0.14062
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.107377
TPM4 tropomyosin 4 -0.0990683
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0970718
NALF1 NALCN channel auxiliary factor 1 -0.0959913
PTMA prothymosin, alpha -0.0913455
FN1 fibronectin 1 -0.0783426
RPS6 ribosomal protein S6 -0.074499
PDE4D phosphodiesterase 4D, cAMP-specific -0.0744125
POTEF POTE ankyrin domain family, member F -0.0738675
P4HB prolyl 4-hydroxylase, beta polypeptide -0.071771
RPL35A ribosomal protein L35a -0.0656857
PDIA3 protein disulfide isomerase family A, member 3 -0.0644754
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0591166
RPLP1 ribosomal protein, large, P1 -0.0555004
B2M beta-2-microglobulin -0.0553512
NLGN1 neuroligin 1 -0.0540998
PGK1 phosphoglycerate kinase 1 -0.0522842
GARS1 glycyl-tRNA synthetase 1 -0.0517555
MAP1B microtubule-associated protein 1B -0.050962
PKM pyruvate kinase, muscle -0.0498754
ANKRD11 ankyrin repeat domain 11 -0.0498023
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0496804
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0491966
RPS8 ribosomal protein S8 -0.0487018
SBF2 SET binding factor 2 -0.0485906
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0481025
HLA-A major histocompatibility complex, class I, A -0.0477262
MT2A metallothionein 2A -0.0466552
GRB10 growth factor receptor-bound protein 10 -0.0466171
RPL28 ribosomal protein L28 -0.0457478
LOC112694756 uncharaterized LOC112694756 -0.0442435
HLA-B major histocompatibility complex, class I, B -0.0439607
RPLP2 ribosomal protein, large, P2 -0.0437506
TPI1 triosephosphate isomerase 1 -0.0432322
RPS19 ribosomal protein S19 -0.0432106
IGFBP5 insulin-like growth factor binding protein 5 -0.0428392
ZBTB20 zinc finger and BTB domain containing 20 -0.0427839
RTN4 reticulon 4 -0.042652
GNAS GNAS complex locus -0.0400421
FNDC3B fibronectin type III domain containing 3B -0.0398136
LPP LIM domain containing preferred translocation partner in lipoma -0.0382276
S100A6 S100 calcium binding protein A6 -0.0377182
RPS13 ribosomal protein S13 -0.0372241
CALR calreticulin -0.0369383
AHNAK AHNAK nucleoprotein -0.0365646
CADM1 cell adhesion molecule 1 -0.0346415
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0342192
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0339862
PFN1 profilin 1 -0.0330667
ACTG1 actin gamma 1 -0.0329949
TNS3 tensin 3 -0.0325769
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0324338
S100A9 S100 calcium binding protein A9 -0.0323972
SEC61G Sec61 gamma subunit -0.0323958
ZFAND3 zinc finger, AN1-type domain 3 -0.032038
TUBA1B tubulin, alpha 1b -0.0316209
RPL34 ribosomal protein L34 -0.0315871
PTK2 protein tyrosine kinase 2 -0.0311167
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0309931
LMNA lamin A/C -0.0308104
ENO2 enolase 2 (gamma, neuronal) -0.0303401
RPL19 ribosomal protein L19 -0.0302971
KPNB1 karyopherin (importin) beta 1 -0.0300107
EXT1 exostosin glycosyltransferase 1 -0.0297132
LMAN1 lectin, mannose-binding, 1 -0.029695
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0294798
VCL vinculin -0.0294641
TPT1 tumor protein, translationally-controlled 1 -0.0294407
RPS23 ribosomal protein S23 -0.029355
NAV1 neuron navigator 1 -0.029199
CKAP4 cytoskeleton-associated protein 4 -0.0291626
CBX3 chromobox homolog 3 -0.0289113
RAB7A RAB7A, member RAS oncogene family -0.0288316
CLMP CXADR-like membrane protein -0.028781
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0286693
RPL9 ribosomal protein L9 -0.0286025
ACTN4 actinin, alpha 4 -0.0285961
TENM3 teneurin transmembrane protein 3 -0.0283838
SOX5 SRY (sex determining region Y)-box 5 -0.0277767
EIF1 eukaryotic translation initiation factor 1 -0.0275491
RPL27A ribosomal protein L27a -0.0274185
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0271456
RPL31 ribosomal protein L31 -0.0266832
HILPDA hypoxia inducible lipid droplet-associated -0.0265755
HIP1 huntingtin interacting protein 1 -0.0263694
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0262582
NAP1L1 nucleosome assembly protein 1-like 1 -0.0262454
FTH1 ferritin, heavy polypeptide 1 -0.0261526
LYPD6B LY6/PLAUR domain containing 6B -0.0260395
RPL23 ribosomal protein L23 -0.025951
SDK1 sidekick cell adhesion molecule 1 -0.0257424
SEPTIN7 septin 7 -0.0257243
UBE2K ubiquitin-conjugating enzyme E2K -0.0255137
RPS21 ribosomal protein S21 -0.0254162
RNF216 ring finger protein 216 -0.0253885
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0253703