(R)-Verapamil (hydrochloride)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (R)-Verapamil (hydrochloride) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the (R)-Verapamil (hydrochloride)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.168565
PRELID2 PRELI domain containing 2 0.132802
RAD51B RAD51 paralog B 0.0928635
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0811705
TMSB10 thymosin beta 10 0.0736097
ALCAM activated leukocyte cell adhesion molecule 0.0720624
PSD3 pleckstrin and Sec7 domain containing 3 0.0690994
MACROD2 MACRO domain containing 2 0.0671806
FLNA filamin A, alpha 0.0653509
SMYD3 SET and MYND domain containing 3 0.0630182
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0608956
FHIT fragile histidine triad 0.0601348
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0590531
RPS4X ribosomal protein S4, X-linked 0.0583015
NDRG1 N-myc downstream regulated 1 0.0570759
RUNX1 runt-related transcription factor 1 0.0568707
CLTC clathrin, heavy chain (Hc) 0.0560059
TBC1D5 TBC1 domain family, member 5 0.0552003
BCL2L1 BCL2-like 1 0.0543723
RPS12 ribosomal protein S12 0.0534424
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0533506
FLNB filamin B, beta 0.0532032
ASPH aspartate beta-hydroxylase 0.0524388
ATXN1 ataxin 1 0.0506007
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0491715
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0488369
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0481628
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0479393
SVIL supervillin 0.0478233
TJP1 tight junction protein 1 0.0467709
ECT2 epithelial cell transforming 2 0.0454677
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0444116
ZBTB20 zinc finger and BTB domain containing 20 0.0442475
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0442355
WWOX WW domain containing oxidoreductase 0.0441678
RPS3 ribosomal protein S3 0.0440131
RPS17 ribosomal protein S17 0.0440088
TRIO trio Rho guanine nucleotide exchange factor 0.0427209
OSBPL10 oxysterol binding protein-like 10 0.0422108
SMAD3 SMAD family member 3 0.0410729
EZR ezrin 0.0400016
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0395845
BBS9 Bardet-Biedl syndrome 9 0.0395407
DIAPH3 diaphanous-related formin 3 0.0391478
MACC1 metastasis associated in colon cancer 1 0.0389499
DOCK1 dedicator of cytokinesis 1 0.0386222
RPL23 ribosomal protein L23 0.0381913
SEPTIN9 septin 9 0.0376211
RNF213 ring finger protein 213 0.0372778
HMGA2 high mobility group AT-hook 2 0.0372596
KIAA1328 KIAA1328 0.0370914
NCEH1 neutral cholesterol ester hydrolase 1 0.0365074
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0364857
FNDC3B fibronectin type III domain containing 3B 0.0364292
RPL18 ribosomal protein L18 0.0364228
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0359994
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0357466
LAMC2 laminin, gamma 2 0.0356425
EXOC4 exocyst complex component 4 0.0356319
MBNL1 muscleblind-like splicing regulator 1 0.0339986
INTS6 integrator complex subunit 6 0.033704
PAX8 paired box 8 0.0329069
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0326694
SPIDR scaffolding protein involved in DNA repair 0.0325381
SUMF1 sulfatase modifying factor 1 0.0324025
CEP128 centrosomal protein 128kDa 0.0320803
EHBP1 EH domain binding protein 1 0.0317734
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0317691
TTC3 tetratricopeptide repeat domain 3 0.0317395
RFC3 replication factor C (activator 1) 3, 38kDa 0.0317066
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0313341
METTL15 methyltransferase like 15 0.0310695
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.031001
RPS8 ribosomal protein S8 0.030972
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0309543
MYO1E myosin IE 0.0307772
EXT1 exostosin glycosyltransferase 1 0.0303984
CSNK1A1 casein kinase 1, alpha 1 0.0301286
CREB5 cAMP responsive element binding protein 5 0.0298046
RPS2 ribosomal protein S2 0.0295811
ACTN4 actinin, alpha 4 0.0290421
ANXA3 annexin A3 0.0285021
ANXA1 annexin A1 0.0284926
ITGA6 integrin, alpha 6 0.0283234
NRIP1 nuclear receptor interacting protein 1 0.0281015
BBX bobby sox homolog (Drosophila) 0.0280382
AFDN afadin, adherens junction formation factor 0.0274168
ANLN anillin, actin binding protein 0.0273265
RPS19 ribosomal protein S19 0.0270586
PARD3B par-3 family cell polarity regulator beta 0.0268977
MBD5 methyl-CpG binding domain protein 5 0.0267754
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0267331
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0262799
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0261473
STAU2 staufen double-stranded RNA binding protein 2 0.0256662
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.025328
RPL9 ribosomal protein L9 0.0252615
CBX3 chromobox homolog 3 0.0251145
CTBP2 C-terminal binding protein 2 0.0250071
FNIP1 folliculin interacting protein 1 0.0246569

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.155945
PTMA prothymosin, alpha -0.126812
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.123954
TPM4 tropomyosin 4 -0.0771441
FTL ferritin, light polypeptide -0.0757589
RPL35A ribosomal protein L35a -0.0732382
FTH1 ferritin, heavy polypeptide 1 -0.0723172
ANXA2 annexin A2 -0.0707568
MATR3 matrin 3 -0.0637846
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0636541
GOLGA4 golgin A4 -0.0558464
PDIA3 protein disulfide isomerase family A, member 3 -0.0535645
PGK1 phosphoglycerate kinase 1 -0.051976
TMSB4X thymosin beta 4, X-linked -0.0518244
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0495484
VDAC1 voltage-dependent anion channel 1 -0.0493268
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0486239
ACTG1 actin gamma 1 -0.0483489
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0469454
AHNAK AHNAK nucleoprotein -0.0456038
CCND1 cyclin D1 -0.0444313
RPS6 ribosomal protein S6 -0.044225
KPNB1 karyopherin (importin) beta 1 -0.0442229
KDM3A lysine (K)-specific demethylase 3A -0.0442068
S100A6 S100 calcium binding protein A6 -0.0437965
EIF1 eukaryotic translation initiation factor 1 -0.0437011
TPT1 tumor protein, translationally-controlled 1 -0.0422505
RHEX regulator of hemoglobinization and erythroid cell expansion -0.0421424
RNF145 ring finger protein 145 -0.0419332
RPS13 ribosomal protein S13 -0.0416056
LOC112694756 uncharaterized LOC112694756 -0.0414455
WDR45B WD repeat domain 45B -0.0406114
POTEF POTE ankyrin domain family, member F -0.0404978
PKM pyruvate kinase, muscle -0.0403331
RPLP1 ribosomal protein, large, P1 -0.0396503
IGFBP3 insulin-like growth factor binding protein 3 -0.0396226
RPL19 ribosomal protein L19 -0.039503
KMT2E lysine (K)-specific methyltransferase 2E -0.0394246
RLF rearranged L-myc fusion -0.0387679
CANX calnexin -0.0367243
ZNF292 zinc finger protein 292 -0.0364966
RPL4 ribosomal protein L4 -0.0348683
RHOA ras homolog family member A -0.0342321
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0339347
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0336678
GNAS GNAS complex locus -0.0336428
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0326794
SETD5 SET domain containing 5 -0.0326679
RSL1D1 ribosomal L1 domain containing 1 -0.0326526
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0324412
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0321052
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0319811
RPS25 ribosomal protein S25 -0.0313345
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.030266
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0302337
NDFIP1 Nedd4 family interacting protein 1 -0.0301456
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0298862
USP3 ubiquitin specific peptidase 3 -0.0293116
LMAN1 lectin, mannose-binding, 1 -0.0287338
WDR43 WD repeat domain 43 -0.0283354
CLINT1 clathrin interactor 1 -0.0280689
EEF1G eukaryotic translation elongation factor 1 gamma -0.0280539
LDHB lactate dehydrogenase B -0.0280079
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0278314
RTN4 reticulon 4 -0.0277609
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0276608
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0272146
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0268757
FBXL2 F-box and leucine-rich repeat protein 2 -0.0268045
SEPTIN7 septin 7 -0.0267812
CLIP2 CAP-GLY domain containing linker protein 2 -0.0265758
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0261648
UGCG UDP-glucose ceramide glucosyltransferase -0.0261033
ENO1 enolase 1, (alpha) -0.0260947
PERP PERP, TP53 apoptosis effector -0.025777
OGA O-GlcNAcase -0.0257603
RAB1A RAB1A, member RAS oncogene family -0.0255634
RPS20 ribosomal protein S20 -0.0255264
RPS16 ribosomal protein S16 -0.0253859
PRRC2B proline-rich coiled-coil 2B -0.0251381
NPEPPS aminopeptidase puromycin sensitive -0.0250229
ANKRD10 ankyrin repeat domain 10 -0.0249838
TUBA1B tubulin, alpha 1b -0.024743
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0245385
INSIG2 insulin induced gene 2 -0.0244365
RAD21 RAD21 homolog (S. pombe) -0.0243654
RPL38 ribosomal protein L38 -0.0243301
RPL15 ribosomal protein L15 -0.0240684
ZNF207 zinc finger protein 207 -0.0239469
H1-0 H1.0 linker histone -0.0239029
KIF5B kinesin family member 5B -0.0233755
RPL34 ribosomal protein L34 -0.0232353
PRRC1 proline-rich coiled-coil 1 -0.023154
DSTN destrin (actin depolymerizing factor) -0.0230389
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0229218
RPLP0 ribosomal protein, large, P0 -0.022875
SELENOK selenoprotein K -0.0228033
CCT8 chaperonin containing TCP1, subunit 8 (theta) -0.0226595
AFF4 AF4/FMR2 family, member 4 -0.0226345
MTDH metadherin -0.0226172