(R)-Verapamil (hydrochloride)_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (R)-Verapamil (hydrochloride) perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the (R)-Verapamil (hydrochloride)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS12 ribosomal protein S12 0.0814766
RPS17 ribosomal protein S17 0.0685505
RPL18 ribosomal protein L18 0.0683757
RPS3 ribosomal protein S3 0.0619868
RPL23 ribosomal protein L23 0.056154
TRAPPC9 trafficking protein particle complex 9 0.0442712
RPS19 ribosomal protein S19 0.0442162
RPS4X ribosomal protein S4, X-linked 0.042042
RPL26 ribosomal protein L26 0.0398262
SLC45A4 solute carrier family 45, member 4 0.0370196
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0361776
TPT1 tumor protein, translationally-controlled 1 0.0357999
NTN4 netrin 4 0.0351469
PRR5L proline rich 5 like 0.0351119
ERRFI1 ERBB receptor feedback inhibitor 1 0.0345565
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0333678
RNF213 ring finger protein 213 0.0329911
IFIH1 interferon induced with helicase C domain 1 0.0325667
LMO7 LIM domain 7 0.0323706
RPL36 ribosomal protein L36 0.0320017
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0318083
PTPRF protein tyrosine phosphatase, receptor type, F 0.0314943
ZSWIM6 zinc finger, SWIM-type containing 6 0.0307718
LCN2 lipocalin 2 0.0285776
PRKN parkin RBR E3 ubiquitin protein ligase 0.0276615
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0275045
VCL vinculin 0.0270048
CTNND1 catenin (cadherin-associated protein), delta 1 0.026904
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0268768
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.025909
S100P S100 calcium binding protein P 0.0257882
SON SON DNA binding protein 0.0254984
IGF2 insulin-like growth factor 2 0.0254233
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0245941
TUFT1 tuftelin 1 0.0242558
PLK2 polo-like kinase 2 0.0241793
PRRC2C proline-rich coiled-coil 2C 0.0241548
SMAD3 SMAD family member 3 0.0229862
RPL9 ribosomal protein L9 0.022684
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0224285
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0223823
NACA nascent polypeptide-associated complex alpha subunit 0.0221067
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0220361
UTRN utrophin 0.0216921
ADARB1 adenosine deaminase, RNA-specific, B1 0.0216768
BABAM2 BRISC and BRCA1 A complex member 2 0.021367
ARHGAP23 Rho GTPase activating protein 23 0.0211391
MYL12B myosin, light chain 12B, regulatory 0.0210107
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0207367
RPL37A ribosomal protein L37a 0.0205754
INTS6 integrator complex subunit 6 0.0205064
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.0204425
CCNYL1 cyclin Y-like 1 0.0192025
CTBP2 C-terminal binding protein 2 0.018967
RPS8 ribosomal protein S8 0.0189022
RBBP6 retinoblastoma binding protein 6 0.0187276
PPARG peroxisome proliferator-activated receptor gamma 0.0186267
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0185371
ADGRG6 adhesion G protein-coupled receptor G6 0.0184061
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0182672
TGFA transforming growth factor, alpha 0.0182671
ZBTB7A zinc finger and BTB domain containing 7A 0.0182581
SPIDR scaffolding protein involved in DNA repair 0.018203
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0179645
EGFR epidermal growth factor receptor 0.0177067
EHBP1 EH domain binding protein 1 0.0176612
CREBBP CREB binding protein 0.017323
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0169469
HOMER1 homer scaffolding protein 1 0.0169253
MYO1E myosin IE 0.0167853
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0167591
SERINC1 serine incorporator 1 0.0165529
OASL 2'-5'-oligoadenylate synthetase-like 0.0161381
ETV6 ets variant 6 0.016012
IER2 immediate early response 2 0.0158969
BCL2L1 BCL2-like 1 0.0157893
TOB1 transducer of ERBB2, 1 0.0157483
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0157328
STIM2 stromal interaction molecule 2 0.0155347
CLPTM1L CLPTM1-like 0.0153272
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0153134
MT2A metallothionein 2A 0.0149471
CFB complement factor B 0.0149435
NCEH1 neutral cholesterol ester hydrolase 1 0.0149183
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0149062
RPL32 ribosomal protein L32 0.0148258
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0144747
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0144625
MAML3 mastermind-like 3 (Drosophila) 0.0144263
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0143232
METTL15 methyltransferase like 15 0.0143032
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 0.0142443
FMN1 formin 1 0.0141253
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.0140481
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0140262
BCAR3 breast cancer anti-estrogen resistance 3 0.013689
WDPCP WD repeat containing planar cell polarity effector 0.01366
ITFG1 integrin alpha FG-GAP repeat containing 1 0.0136546
MGLL monoglyceride lipase 0.0136497
ACTN1 actinin, alpha 1 0.0136264

decreased expression

Symbol Name Standardized Value
LYZ lysozyme -0.165354
FTH1 ferritin, heavy polypeptide 1 -0.159365
PTMA prothymosin, alpha -0.147865
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.143751
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.126564
RPS6 ribosomal protein S6 -0.11848
LDHA lactate dehydrogenase A -0.112892
FRY furry homolog (Drosophila) -0.109035
PDIA3 protein disulfide isomerase family A, member 3 -0.105905
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.103184
FTL ferritin, light polypeptide -0.0949184
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0840031
ANXA2 annexin A2 -0.0811308
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0806994
GOLGA4 golgin A4 -0.0793331
RPL35A ribosomal protein L35a -0.0724656
PGK1 phosphoglycerate kinase 1 -0.0704163
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0676877
LOC112694756 uncharaterized LOC112694756 -0.0673644
AHNAK AHNAK nucleoprotein -0.0667361
RPLP1 ribosomal protein, large, P1 -0.0658987
AGR2 anterior gradient 2 -0.0651586
S100A6 S100 calcium binding protein A6 -0.0625203
TXNRD1 thioredoxin reductase 1 -0.0623862
RAD21 RAD21 homolog (S. pombe) -0.0609716
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0601673
ACTG1 actin gamma 1 -0.0600424
PKM pyruvate kinase, muscle -0.0593279
RPS13 ribosomal protein S13 -0.0588044
ITPKC inositol-trisphosphate 3-kinase C -0.0583764
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0558819
ANKRD11 ankyrin repeat domain 11 -0.054915
KRT8 keratin 8, type II -0.0540011
ENO1 enolase 1, (alpha) -0.053655
RAB7A RAB7A, member RAS oncogene family -0.0535567
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0517267
RAB1A RAB1A, member RAS oncogene family -0.0512458
EGR1 early growth response 1 -0.0499206
WASF2 WAS protein family, member 2 -0.0489378
LAMA4 laminin, alpha 4 -0.0488117
CANX calnexin -0.0483427
FNDC3B fibronectin type III domain containing 3B -0.0479879
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0479639
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0477925
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0476968
EEF2 eukaryotic translation elongation factor 2 -0.0466632
KMT2C lysine (K)-specific methyltransferase 2C -0.0459233
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0439328
POTEF POTE ankyrin domain family, member F -0.0438909
TPM4 tropomyosin 4 -0.0436028
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0435526
KPNB1 karyopherin (importin) beta 1 -0.0434223
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0426708
SBF2 SET binding factor 2 -0.0415984
TMEM123 transmembrane protein 123 -0.0415931
EPCAM epithelial cell adhesion molecule -0.0404311
NDRG1 N-myc downstream regulated 1 -0.0403885
S100A10 S100 calcium binding protein A10 -0.0402286
RPL13A ribosomal protein L13a -0.0401494
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0393847
ZMYND8 zinc finger, MYND-type containing 8 -0.039334
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0390868
RSF1 remodeling and spacing factor 1 -0.0390385
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0389565
DSTN destrin (actin depolymerizing factor) -0.0387868
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0387521
KRT19 keratin 19, type I -0.0386127
RPLP0 ribosomal protein, large, P0 -0.0383202
CD2AP CD2-associated protein -0.0381942
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0380255
ABHD2 abhydrolase domain containing 2 -0.0378718
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0376763
KDM2A lysine (K)-specific demethylase 2A -0.0373606
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0371033
TM4SF4 transmembrane 4 L six family member 4 -0.0369664
KDM3A lysine (K)-specific demethylase 3A -0.0369418
LOC102724023 ES1 protein homolog, mitochondrial -0.0364661
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.036426
TAS2R14 taste receptor, type 2, member 14 -0.0362673
EEF1G eukaryotic translation elongation factor 1 gamma -0.03554
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0346914
KRT20 keratin 20, type I -0.0343883
RTN3 reticulon 3 -0.0343497
GSK3B glycogen synthase kinase 3 beta -0.0342131
ZNF292 zinc finger protein 292 -0.0341943
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0341702
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0338439
KIF5B kinesin family member 5B -0.0338419
ERBIN erbb2 interacting protein -0.0336846
TRIB1 tribbles pseudokinase 1 -0.0336601
ARF1 ADP-ribosylation factor 1 -0.0336224
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0335276
RPL19 ribosomal protein L19 -0.0333001
EIF1 eukaryotic translation initiation factor 1 -0.0332169
RPL4 ribosomal protein L4 -0.0330376
IARS1 isoleucyl-tRNA synthetase 1 -0.033035
ESYT2 extended synaptotagmin-like protein 2 -0.0328271
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0327061
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0326789
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0326092