(R)-Verapamil (hydrochloride)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (R)-Verapamil (hydrochloride) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the (R)-Verapamil (hydrochloride)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PODXL podocalyxin-like 0.101925
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0805884
BCAR3 breast cancer anti-estrogen resistance 3 0.0805644
BCL2L1 BCL2-like 1 0.0804745
LMO7 LIM domain 7 0.0676037
FLNB filamin B, beta 0.0585219
AOPEP aminopeptidase O (putative) 0.0552862
MACF1 microtubule-actin crosslinking factor 1 0.0498728
PDE4D phosphodiesterase 4D, cAMP-specific 0.0491724
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0469516
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0451545
FOXO1 forkhead box O1 0.0447841
DOCK5 dedicator of cytokinesis 5 0.0443918
DST dystonin 0.0412116
ANKRD28 ankyrin repeat domain 28 0.0411334
ARHGAP29 Rho GTPase activating protein 29 0.0408216
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0407067
JAG1 jagged 1 0.0388568
RASAL2 RAS protein activator like 2 0.0375315
TXNIP thioredoxin interacting protein 0.0375193
TSC22D1 TSC22 domain family, member 1 0.0362097
DOK5 docking protein 5 0.0341608
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0339288
APP amyloid beta (A4) precursor protein 0.0332113
SEPTIN9 septin 9 0.0330978
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0320382
KLF5 Kruppel-like factor 5 (intestinal) 0.0308953
TXNRD1 thioredoxin reductase 1 0.0304463
MYH9 myosin, heavy chain 9, non-muscle 0.0303951
AMOTL1 angiomotin like 1 0.0299069
PLAT plasminogen activator, tissue 0.0298648
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0297681
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.0280962
CD44 CD44 molecule (Indian blood group) 0.027989
PICALM phosphatidylinositol binding clathrin assembly protein 0.0272774
EZR ezrin 0.0271042
EXT1 exostosin glycosyltransferase 1 0.0268847
ACTN1 actinin, alpha 1 0.0266644
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0260297
ARRDC3 arrestin domain containing 3 0.0259023
MTAP methylthioadenosine phosphorylase 0.0256322
PRRC2C proline-rich coiled-coil 2C 0.0254982
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.025172
DGKD diacylglycerol kinase, delta 130kDa 0.0250557
FRMD6 FERM domain containing 6 0.0248339
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0247033
KRT6A keratin 6A, type II 0.0245244
VEGFC vascular endothelial growth factor C 0.0238857
MBNL1 muscleblind-like splicing regulator 1 0.023719
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0234584
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0230594
MKI67 marker of proliferation Ki-67 0.0227992
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0227828
THOC2 THO complex 2 0.0225098
TJP1 tight junction protein 1 0.022391
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0221033
SEPTIN11 septin 11 0.0219985
BARX2 BARX homeobox 2 0.0218428
DOCK9 dedicator of cytokinesis 9 0.0217805
FOXP1 forkhead box P1 0.0215942
ZSWIM6 zinc finger, SWIM-type containing 6 0.0215459
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0214614
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0214002
SPIDR scaffolding protein involved in DNA repair 0.0213896
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0213492
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0212667
DUSP4 dual specificity phosphatase 4 0.0212189
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 0.0211827
PITPNB phosphatidylinositol transfer protein, beta 0.0207433
TBC1D2 TBC1 domain family, member 2 0.0203342
MED15 mediator complex subunit 15 0.020321
NPAS2 neuronal PAS domain protein 2 0.0202195
RNF213 ring finger protein 213 0.020164
SIK3 SIK family kinase 3 0.0201604
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0201536
NRG1 neuregulin 1 0.0201031
ARGLU1 arginine and glutamate rich 1 0.0200723
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.020009
IFI44L interferon-induced protein 44-like 0.0199762
EFNB2 ephrin-B2 0.0199403
TBC1D5 TBC1 domain family, member 5 0.019914
FAM107B family with sequence similarity 107, member B 0.0199124
EFNA5 ephrin-A5 0.0198099
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0198009
RNF217 ring finger protein 217 0.0197537
BCR breakpoint cluster region 0.019536
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0195267
NEK7 NIMA-related kinase 7 0.0194409
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0194035
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0193021
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0192179
LPP LIM domain containing preferred translocation partner in lipoma 0.0191702
HELZ2 helicase with zinc finger 2, transcriptional coactivator 0.0191624
PLXNA2 plexin A2 0.0191452
TGFA transforming growth factor, alpha 0.0191429
AKAP12 A kinase (PRKA) anchor protein 12 0.0190829
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.0190487
MPRIP myosin phosphatase Rho interacting protein 0.0190217
MN1 meningioma (disrupted in balanced translocation) 1 0.0189269
UBAP2L ubiquitin associated protein 2-like 0.0189257

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.210096
TIMP3 TIMP metallopeptidase inhibitor 3 -0.144488
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.126944
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.123393
TMSB10 thymosin beta 10 -0.109109
LOC112694756 uncharaterized LOC112694756 -0.105745
MTSS1 metastasis suppressor 1 -0.100827
CLU clusterin -0.100372
TMSB4X thymosin beta 4, X-linked -0.0787222
PTMA prothymosin, alpha -0.0757434
GNAS GNAS complex locus -0.075545
RPS6 ribosomal protein S6 -0.0754237
ABI3BP ABI family, member 3 (NESH) binding protein -0.0715498
KRT17 keratin 17, type I -0.0703409
NDRG1 N-myc downstream regulated 1 -0.0681948
ANXA2 annexin A2 -0.0675061
RPS21 ribosomal protein S21 -0.0661478
STC1 stanniocalcin 1 -0.0659856
HM13 histocompatibility (minor) 13 -0.0651037
POTEF POTE ankyrin domain family, member F -0.0615977
RPS13 ribosomal protein S13 -0.0605695
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0581156
PGK1 phosphoglycerate kinase 1 -0.0549449
H1-0 H1.0 linker histone -0.0546334
CANX calnexin -0.0540386
ENO1 enolase 1, (alpha) -0.0537843
INTS6 integrator complex subunit 6 -0.0537412
S100A10 S100 calcium binding protein A10 -0.0526117
RPL34 ribosomal protein L34 -0.0523397
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.050608
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0505804
RPLP1 ribosomal protein, large, P1 -0.0497698
AHNAK AHNAK nucleoprotein -0.0487891
RPS25 ribosomal protein S25 -0.0478343
RPL35A ribosomal protein L35a -0.0473716
PDIA3 protein disulfide isomerase family A, member 3 -0.0466663
S100A2 S100 calcium binding protein A2 -0.0463053
WASF2 WAS protein family, member 2 -0.0462246
MT2A metallothionein 2A -0.0453286
RPLP2 ribosomal protein, large, P2 -0.045066
LMNA lamin A/C -0.0446616
RPS19 ribosomal protein S19 -0.0445001
RPL11 ribosomal protein L11 -0.0440366
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0432262
EFHD2 EF-hand domain family, member D2 -0.0421524
S100A6 S100 calcium binding protein A6 -0.0420275
TPT1 tumor protein, translationally-controlled 1 -0.0416062
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0411512
GARS1 glycyl-tRNA synthetase 1 -0.0410546
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0409405
GOLGA4 golgin A4 -0.04092
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0402681
RPS24 ribosomal protein S24 -0.0398689
PALLD palladin, cytoskeletal associated protein -0.0396077
RPL12 ribosomal protein L12 -0.0386552
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0385865
EMP1 epithelial membrane protein 1 -0.0383172
RAI14 retinoic acid induced 14 -0.0382827
NAV2 neuron navigator 2 -0.0377455
RPL8 ribosomal protein L8 -0.0377361
FSCN1 fascin actin-bundling protein 1 -0.0372712
RPL27A ribosomal protein L27a -0.0369124
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0367096
SQLE squalene epoxidase -0.0365434
ALCAM activated leukocyte cell adhesion molecule -0.0365063
KIAA1217 KIAA1217 -0.0359605
RPS16 ribosomal protein S16 -0.0357194
PKM pyruvate kinase, muscle -0.0354037
SERTAD2 SERTA domain containing 2 -0.0350977
FTH1 ferritin, heavy polypeptide 1 -0.0346498
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0346151
RPL30 ribosomal protein L30 -0.0346104
RPL19 ribosomal protein L19 -0.0345759
UBC ubiquitin C -0.0338534
RPLP0 ribosomal protein, large, P0 -0.032473
RPS23 ribosomal protein S23 -0.0324345
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.032429
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0324059
RPL37 ribosomal protein L37 -0.0321415
RAP1B RAP1B, member of RAS oncogene family -0.0321316
SQSTM1 sequestosome 1 -0.0320408
RPS14 ribosomal protein S14 -0.0320106
TPM4 tropomyosin 4 -0.0319229
RPS8 ribosomal protein S8 -0.0318022
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0316452
HLA-B major histocompatibility complex, class I, B -0.0313889
RPL23 ribosomal protein L23 -0.0313432
COPB1 coatomer protein complex, subunit beta 1 -0.030959
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0308223
S100A4 S100 calcium binding protein A4 -0.0307961
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0307633
DSTN destrin (actin depolymerizing factor) -0.0306989
RPL32 ribosomal protein L32 -0.0304237
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0301824
CALR calreticulin -0.029219
ITCH itchy E3 ubiquitin protein ligase -0.0291418
VDAC1 voltage-dependent anion channel 1 -0.0290892
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0290005
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0289313
S100A9 S100 calcium binding protein A9 -0.0288698