(R)-Verapamil (hydrochloride)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (R)-Verapamil (hydrochloride) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the (R)-Verapamil (hydrochloride)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KRT18 keratin 18, type I 0.0880592
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0725326
MYO1E myosin IE 0.0575824
ABHD17C abhydrolase domain containing 17C 0.0542541
PKP2 plakophilin 2 0.0537355
RPS3 ribosomal protein S3 0.0528724
SERINC5 serine incorporator 5 0.0460329
PRSS3 protease, serine, 3 0.0450267
BCL2L1 BCL2-like 1 0.0447499
RIMKLB ribosomal modification protein rimK-like family member B 0.043381
TRIM2 tripartite motif containing 2 0.0431676
AHCYL2 adenosylhomocysteinase-like 2 0.0422881
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0400714
FAT1 FAT atypical cadherin 1 0.0381673
RPS4X ribosomal protein S4, X-linked 0.0372598
RPS12 ribosomal protein S12 0.0365157
KLF6 Kruppel-like factor 6 0.0361146
HSPA8 heat shock 70kDa protein 8 0.0351767
ITPRID2 ITPR interacting domain containing 2 0.0351259
TNRC18 trinucleotide repeat containing 18 0.0346469
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0344857
EXT1 exostosin glycosyltransferase 1 0.032423
KIF5B kinesin family member 5B 0.0314415
RPS8 ribosomal protein S8 0.0301919
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.0294184
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0293004
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0292045
EIF1 eukaryotic translation initiation factor 1 0.0288685
KLF3 Kruppel-like factor 3 (basic) 0.0286559
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.0286463
TPT1 tumor protein, translationally-controlled 1 0.0273508
RPL37A ribosomal protein L37a 0.0263218
NCOA7 nuclear receptor coactivator 7 0.0263188
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.0262135
RPL31 ribosomal protein L31 0.0255545
RPL12 ribosomal protein L12 0.0254887
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0254872
RACK1 receptor for activated C kinase 1 0.0254632
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 0.0248782
TSPAN8 tetraspanin 8 0.0247691
LDHA lactate dehydrogenase A 0.0244674
TXNRD1 thioredoxin reductase 1 0.0244387
CAB39 calcium binding protein 39 0.0237455
SQSTM1 sequestosome 1 0.0237241
ENO1 enolase 1, (alpha) 0.0235841
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0235016
PCDHB16 protocadherin beta 16 0.0233005
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.0231666
RAD21 RAD21 homolog (S. pombe) 0.0227717
RAP1B RAP1B, member of RAS oncogene family 0.0220993
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0220704
NFE2L2 nuclear factor, erythroid 2-like 2 0.0219288
MARS1 methionyl-tRNA synthetase 1 0.0218546
NT5C2 5'-nucleotidase, cytosolic II 0.0215136
DUSP4 dual specificity phosphatase 4 0.0214503
PELI1 pellino E3 ubiquitin protein ligase 1 0.0213731
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0212251
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0211346
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0209055
UBAP2L ubiquitin associated protein 2-like 0.0208433
RPS29 ribosomal protein S29 0.0208202
P3H2 prolyl 3-hydroxylase 2 0.0208175
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.020462
ARHGAP29 Rho GTPase activating protein 29 0.0199918
MTUS1 microtubule associated tumor suppressor 1 0.0199691
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0198945
NOSTRIN nitric oxide synthase trafficking 0.019776
S100P S100 calcium binding protein P 0.0193584
SHROOM3 shroom family member 3 0.0192755
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0192543
TMEM45B transmembrane protein 45B 0.0192513
TSPAN3 tetraspanin 3 0.0190788
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0189777
NACA nascent polypeptide-associated complex alpha subunit 0.0188321
CANX calnexin 0.0187257
SRI sorcin 0.018666
ERRFI1 ERBB receptor feedback inhibitor 1 0.0183933
EFNA1 ephrin-A1 0.0182921
RSL1D1 ribosomal L1 domain containing 1 0.0182667
IL6ST interleukin 6 signal transducer 0.0181086
ATP10B ATPase, class V, type 10B 0.0180622
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0179756
RPL18 ribosomal protein L18 0.0178352
EREG epiregulin 0.0178252
MX1 MX dynamin-like GTPase 1 0.0177453
FTL ferritin, light polypeptide 0.0175145
RPS17 ribosomal protein S17 0.0174921
FBXL17 F-box and leucine-rich repeat protein 17 0.0174466
GOLM1 golgi membrane protein 1 0.0171356
IFITM3 interferon induced transmembrane protein 3 0.0171276
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.0171038
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0168235
GDA guanine deaminase 0.0167921
COX6C cytochrome c oxidase subunit VIc 0.016783
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0166783
NEK7 NIMA-related kinase 7 0.0166465
WWC1 WW and C2 domain containing 1 0.0164121
MT2A metallothionein 2A 0.0163187
SNX6 sorting nexin 6 0.0162557
LRP6 low density lipoprotein receptor-related protein 6 0.0161857

decreased expression

Symbol Name Standardized Value
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.140111
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.112605
ANXA2 annexin A2 -0.110534
THSD4 thrombospondin, type I, domain containing 4 -0.105153
GMDS GDP-mannose 4,6-dehydratase -0.101565
PDE4D phosphodiesterase 4D, cAMP-specific -0.10022
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0984106
MSI2 musashi RNA-binding protein 2 -0.0981576
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0974641
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0864276
F3 coagulation factor III (thromboplastin, tissue factor) -0.0813977
CALB1 calbindin 1, 28kDa -0.0780893
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0719946
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0705662
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0688939
PCBP2 poly(rC) binding protein 2 -0.0663369
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0610671
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0606041
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0600106
PDIA3 protein disulfide isomerase family A, member 3 -0.0573569
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0564163
INTS6 integrator complex subunit 6 -0.0550146
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0536501
MAML2 mastermind-like 2 (Drosophila) -0.0535046
FHIT fragile histidine triad -0.0530067
ESYT2 extended synaptotagmin-like protein 2 -0.0519275
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0519171
RABGAP1L RAB GTPase activating protein 1-like -0.0516645
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0514936
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0505001
KMT2C lysine (K)-specific methyltransferase 2C -0.0502601
SRRM2 serine/arginine repetitive matrix 2 -0.0499672
FRMD5 FERM domain containing 5 -0.0498397
ITGB4 integrin, beta 4 -0.049324
PTBP3 polypyrimidine tract binding protein 3 -0.0471048
MCU mitochondrial calcium uniporter -0.046759
PPARG peroxisome proliferator-activated receptor gamma -0.0464499
FNDC3B fibronectin type III domain containing 3B -0.046389
SBF2 SET binding factor 2 -0.0462064
PERP PERP, TP53 apoptosis effector -0.0457706
NFIA nuclear factor I/A -0.0453041
HMGA1 high mobility group AT-hook 1 -0.0447759
ZNF638 zinc finger protein 638 -0.0446666
NPSR1 neuropeptide S receptor 1 -0.0443784
ACTG1 actin gamma 1 -0.0440848
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0440797
SEC31A SEC31 homolog A (S. cerevisiae) -0.0440727
PKM pyruvate kinase, muscle -0.0438762
LMO7 LIM domain 7 -0.0436248
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0428436
RPS6 ribosomal protein S6 -0.042431
BRWD1 bromodomain and WD repeat domain containing 1 -0.0417872
GOLGA4 golgin A4 -0.0416893
AOPEP aminopeptidase O (putative) -0.0412991
BRD2 bromodomain containing 2 -0.0411737
NCOR2 nuclear receptor corepressor 2 -0.04114
SETD5 SET domain containing 5 -0.0408562
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0406521
RBM25 RNA binding motif protein 25 -0.0403327
KRT8 keratin 8, type II -0.0402956
TMSB10 thymosin beta 10 -0.0397054
VMP1 vacuole membrane protein 1 -0.0396647
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0394815
DENND1A DENN/MADD domain containing 1A -0.0392574
ZNF609 zinc finger protein 609 -0.0389178
MPRIP myosin phosphatase Rho interacting protein -0.038801
ARF4 ADP-ribosylation factor 4 -0.0384254
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0383977
PSD3 pleckstrin and Sec7 domain containing 3 -0.0383915
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0383032
FOXO3 forkhead box O3 -0.0382991
RREB1 ras responsive element binding protein 1 -0.0380364
SVIL supervillin -0.0379637
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0375652
LRPPRC leucine-rich pentatricopeptide repeat containing -0.037335
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0361811
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.03581
USP3 ubiquitin specific peptidase 3 -0.0356614
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0352958
LOC112694756 uncharaterized LOC112694756 -0.0350622
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -0.0349428
UBAP2 ubiquitin associated protein 2 -0.03492
PIAS1 protein inhibitor of activated STAT, 1 -0.0346386
GLG1 golgi glycoprotein 1 -0.034515
BACE2 beta-site APP-cleaving enzyme 2 -0.0344589
PTMA prothymosin, alpha -0.0344209
POTEF POTE ankyrin domain family, member F -0.0343842
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -0.0341312
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0339992
ATP5F1B ATP synthase F1 subunit beta -0.0339781
PRELID2 PRELI domain containing 2 -0.0339534
TMEM165 transmembrane protein 165 -0.0338556
PTPRB protein tyrosine phosphatase, receptor type, B -0.0337236
EXOC4 exocyst complex component 4 -0.0334462
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.033315
ALCAM activated leukocyte cell adhesion molecule -0.0332316
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0327853
ACTN4 actinin, alpha 4 -0.0326676
TAS2R14 taste receptor, type 2, member 14 -0.0326131
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0326003