(R)-Verapamil (hydrochloride)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (R)-Verapamil (hydrochloride) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the (R)-Verapamil (hydrochloride)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRB10 growth factor receptor-bound protein 10 0.0803556
MT2A metallothionein 2A 0.0732994
AKAP12 A kinase (PRKA) anchor protein 12 0.0720057
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0692269
ARHGAP5 Rho GTPase activating protein 5 0.0690674
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.066956
SMAD3 SMAD family member 3 0.0645946
ANGPTL4 angiopoietin-like 4 0.0629105
NDRG1 N-myc downstream regulated 1 0.0598689
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0581461
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0562443
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0490738
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0476661
BASP1 brain abundant, membrane attached signal protein 1 0.0467714
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0433324
FLNB filamin B, beta 0.0432775
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0408889
RPS12 ribosomal protein S12 0.0407107
RARB retinoic acid receptor, beta 0.0397714
SIK3 SIK family kinase 3 0.0392082
MYO10 myosin X 0.0366309
ANXA1 annexin A1 0.035751
NAV2 neuron navigator 2 0.0353392
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0353013
HAS2 hyaluronan synthase 2 0.0349337
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0346927
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0338604
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0338387
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0333624
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0330896
MAST4 microtubule associated serine/threonine kinase family member 4 0.0323121
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0321441
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0306611
SFTPA2 surfactant protein A2 0.0302392
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0292835
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0292076
RAB8B RAB8B, member RAS oncogene family 0.0290555
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0285729
PCBP2 poly(rC) binding protein 2 0.0285239
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0281678
STK38L serine/threonine kinase 38 like 0.0280908
ECE1 endothelin converting enzyme 1 0.0277065
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0273463
PRRC2C proline-rich coiled-coil 2C 0.0270903
ERRFI1 ERBB receptor feedback inhibitor 1 0.0266655
APP amyloid beta (A4) precursor protein 0.0265762
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0263103
KLF6 Kruppel-like factor 6 0.0259956
SVIL supervillin 0.0259134
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.025495
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0251588
AKAP13 A kinase (PRKA) anchor protein 13 0.0247135
ADD3 adducin 3 (gamma) 0.0247122
ELL2 elongation factor, RNA polymerase II, 2 0.0239231
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.023903
TGM2 transglutaminase 2 0.0238251
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0231609
FBXO32 F-box protein 32 0.0226031
MED13L mediator complex subunit 13-like 0.0225737
RPS3 ribosomal protein S3 0.0225483
EZR ezrin 0.0222641
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0221983
PELI1 pellino E3 ubiquitin protein ligase 1 0.0221289
HIPK2 homeodomain interacting protein kinase 2 0.0219517
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0218703
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0218471
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.0217884
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0215803
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0215357
RPL36 ribosomal protein L36 0.0212346
IFI44L interferon-induced protein 44-like 0.0211177
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0209253
SLMAP sarcolemma associated protein 0.0206572
LGALS12 lectin, galactoside-binding, soluble, 12 0.0205563
PODXL podocalyxin-like 0.0205228
PTPRM protein tyrosine phosphatase, receptor type, M 0.0204787
GLS2 glutaminase 2 (liver, mitochondrial) 0.0204665
IRAK2 interleukin-1 receptor-associated kinase 2 0.0203308
RPS17 ribosomal protein S17 0.0202334
HMGA1 high mobility group AT-hook 1 0.0200449
FOXL1 forkhead box L1 0.0197389
ZEB1 zinc finger E-box binding homeobox 1 0.0194966
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0194866
USP3 ubiquitin specific peptidase 3 0.0194254
RUNX1 runt-related transcription factor 1 0.0193818
YBX3 Y box binding protein 3 0.0193788
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0192763
SERINC1 serine incorporator 1 0.0192629
RPS19 ribosomal protein S19 0.0191905
PDIA4 protein disulfide isomerase family A, member 4 0.0190487
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0189899
WWTR1 WW domain containing transcription regulator 1 0.0188327
AMPD3 adenosine monophosphate deaminase 3 0.0185746
SHB Src homology 2 domain containing adaptor protein B 0.0184025
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0182283
BHLHE40 basic helix-loop-helix family, member e40 0.0178464
TXNIP thioredoxin interacting protein 0.0176837
ARHGAP26 Rho GTPase activating protein 26 0.0175649
HSPA8 heat shock 70kDa protein 8 0.0174136
DDIT4 DNA-damage-inducible transcript 4 0.0173974

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.146326
VIM vimentin -0.144359
LOX lysyl oxidase -0.140178
P4HB prolyl 4-hydroxylase, beta polypeptide -0.127874
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.121018
CXCL8 chemokine (C-X-C motif) ligand 8 -0.108173
GOLGA4 golgin A4 -0.106096
CDH13 cadherin 13 -0.0903425
PDE4D phosphodiesterase 4D, cAMP-specific -0.0899806
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0845146
IGFBP3 insulin-like growth factor binding protein 3 -0.0834015
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0757278
NRG1 neuregulin 1 -0.0749943
DPYD dihydropyrimidine dehydrogenase -0.0727723
OSMR oncostatin M receptor -0.0702166
FTH1 ferritin, heavy polypeptide 1 -0.0679542
SEC31A SEC31 homolog A (S. cerevisiae) -0.0670831
RAB1A RAB1A, member RAS oncogene family -0.0666397
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0660701
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0656323
RPL35A ribosomal protein L35a -0.0645923
PDIA3 protein disulfide isomerase family A, member 3 -0.0636259
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0610237
TFPI2 tissue factor pathway inhibitor 2 -0.0598329
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0597651
HM13 histocompatibility (minor) 13 -0.0594972
USP34 ubiquitin specific peptidase 34 -0.0579075
EIF1 eukaryotic translation initiation factor 1 -0.0572763
STC1 stanniocalcin 1 -0.0560692
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0559581
SDK1 sidekick cell adhesion molecule 1 -0.0545199
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0537197
COPB1 coatomer protein complex, subunit beta 1 -0.0522439
LMAN1 lectin, mannose-binding, 1 -0.0514857
DDIT3 DNA-damage-inducible transcript 3 -0.0511671
ZMYND8 zinc finger, MYND-type containing 8 -0.0508505
CLIC4 chloride intracellular channel 4 -0.0483867
MON2 MON2 homolog (S. cerevisiae) -0.0474834
TTC3 tetratricopeptide repeat domain 3 -0.0462011
EGFR epidermal growth factor receptor -0.045537
FBN1 fibrillin 1 -0.0452636
RBM39 RNA binding motif protein 39 -0.0450307
ATG7 autophagy related 7 -0.0449313
MEF2A myocyte enhancer factor 2A -0.0446641
EGR1 early growth response 1 -0.0437649
CALU calumenin -0.0425055
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0423802
TMEM165 transmembrane protein 165 -0.041093
ZBTB20 zinc finger and BTB domain containing 20 -0.0402405
PTMA prothymosin, alpha -0.0398777
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0396607
SETD5 SET domain containing 5 -0.0395137
ZNF804A zinc finger protein 804A -0.0389794
DNER delta/notch-like EGF repeat containing -0.038865
TPM4 tropomyosin 4 -0.0387541
VRK2 vaccinia related kinase 2 -0.0384348
NAMPT nicotinamide phosphoribosyltransferase -0.0379501
KDM2A lysine (K)-specific demethylase 2A -0.037831
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0368623
TNNC1 troponin C type 1 (slow) -0.0365938
GPC6 glypican 6 -0.0361689
BTG1 B-cell translocation gene 1, anti-proliferative -0.0358506
RAI14 retinoic acid induced 14 -0.0357228
SOS2 son of sevenless homolog 2 (Drosophila) -0.0354335
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0352316
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0351018
GLCCI1 glucocorticoid induced 1 -0.035078
VCL vinculin -0.0349093
TAS2R14 taste receptor, type 2, member 14 -0.0348475
SEC24D SEC24 family member D -0.0347522
PCNX4 pecanex 4 -0.0346981
POTEF POTE ankyrin domain family, member F -0.0346432
NPC1 Niemann-Pick disease, type C1 -0.0346413
OPTN optineurin -0.0344352
OXR1 oxidation resistance 1 -0.0344097
RPS13 ribosomal protein S13 -0.0343563
RPS25 ribosomal protein S25 -0.0340745
TMTC1 transmembrane and tetratricopeptide repeat containing 1 -0.0339698
PID1 phosphotyrosine interaction domain containing 1 -0.0339197
CUX1 cut-like homeobox 1 -0.0335071
FRMD4A FERM domain containing 4A -0.033237
ARF4 ADP-ribosylation factor 4 -0.0330254
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0328796
CANX calnexin -0.032542
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0322293
RPL31 ribosomal protein L31 -0.0318668
BTBD9 BTB (POZ) domain containing 9 -0.0318007
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0316962
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0316008
SCFD1 sec1 family domain containing 1 -0.0312651
CFDP1 craniofacial development protein 1 -0.0310107
ETV6 ets variant 6 -0.0309823
PRRX1 paired related homeobox 1 -0.0309098
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0306595
HIP1 huntingtin interacting protein 1 -0.0306155
COL12A1 collagen, type XII, alpha 1 -0.0303475
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0302212
RAB5A RAB5A, member RAS oncogene family -0.03011
LOC112694756 uncharaterized LOC112694756 -0.0300915
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0300565