(R)-Verapamil (hydrochloride)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (R)-Verapamil (hydrochloride) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the (R)-Verapamil (hydrochloride)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.131414
ERRFI1 ERBB receptor feedback inhibitor 1 0.0943199
AKAP12 A kinase (PRKA) anchor protein 12 0.0899147
MCL1 myeloid cell leukemia 1 0.0892188
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0687636
PDE4D phosphodiesterase 4D, cAMP-specific 0.065587
GRAMD1B GRAM domain containing 1B 0.0655765
THSD4 thrombospondin, type I, domain containing 4 0.0655218
DOCK5 dedicator of cytokinesis 5 0.0641904
YBX3 Y box binding protein 3 0.0621089
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0578988
VCL vinculin 0.0554851
RIMS2 regulating synaptic membrane exocytosis 2 0.0543814
PDE10A phosphodiesterase 10A 0.0538239
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0538121
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0528141
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0508138
ELL2 elongation factor, RNA polymerase II, 2 0.0506534
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0490681
OSMR oncostatin M receptor 0.0463566
PDLIM5 PDZ and LIM domain 5 0.0463256
WWOX WW domain containing oxidoreductase 0.0462744
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.045979
INTS6 integrator complex subunit 6 0.0435025
EXT1 exostosin glycosyltransferase 1 0.0434632
ZSWIM6 zinc finger, SWIM-type containing 6 0.0430507
PRH1 proline-rich protein HaeIII subfamily 1 0.0426052
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0421378
AFF3 AF4/FMR2 family, member 3 0.0404008
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0389284
EGR1 early growth response 1 0.0387537
RAD51B RAD51 paralog B 0.0387064
ACTN1 actinin, alpha 1 0.0376644
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0376069
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0357534
WNT2B wingless-type MMTV integration site family, member 2B 0.0345097
CALD1 caldesmon 1 0.0344613
HOMER1 homer scaffolding protein 1 0.0340838
AEBP2 AE binding protein 2 0.0329314
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0328546
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0327686
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0319808
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0314447
UBAP2L ubiquitin associated protein 2-like 0.03123
FNDC3B fibronectin type III domain containing 3B 0.0306337
NABP1 nucleic acid binding protein 1 0.0299572
POTEF POTE ankyrin domain family, member F 0.0293541
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0293026
HMGA2 high mobility group AT-hook 2 0.029238
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0291439
IFI6 interferon, alpha-inducible protein 6 0.0281202
SVIL supervillin 0.0275701
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0271108
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0267245
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0266352
PRELID2 PRELI domain containing 2 0.0257036
PRKCE protein kinase C, epsilon 0.0256839
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0254752
CMIP c-Maf inducing protein 0.0251237
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0249796
ATP11A ATPase, class VI, type 11A 0.0247125
RABGAP1L RAB GTPase activating protein 1-like 0.0242542
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0240728
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0239119
EXOC4 exocyst complex component 4 0.0237628
DOCK1 dedicator of cytokinesis 1 0.0227904
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0218901
ATXN1 ataxin 1 0.0213938
R3HDM2 R3H domain containing 2 0.0213738
BRD2 bromodomain containing 2 0.021309
WWTR1 WW domain containing transcription regulator 1 0.0209193
HMOX1 heme oxygenase 1 0.0207841
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0207506
YAP1 Yes-associated protein 1 0.0206985
FUS FUS RNA binding protein 0.0205903
RNF213 ring finger protein 213 0.0202374
STC1 stanniocalcin 1 0.0202135
LOC102724023 ES1 protein homolog, mitochondrial 0.0201538
SNAP25 synaptosomal-associated protein, 25kDa 0.0199918
BNC2 basonuclin 2 0.0195565
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0195192
FMNL2 formin-like 2 0.0193819
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0192223
DNAH14 dynein, axonemal, heavy chain 14 0.018945
SPIDR scaffolding protein involved in DNA repair 0.0189242
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.018903
SFPQ splicing factor proline/glutamine-rich 0.0188959
NLGN1 neuroligin 1 0.0188231
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0188189
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.018802
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0187667
LOXL2 lysyl oxidase-like 2 0.0186131
KMT2D lysine (K)-specific methyltransferase 2D 0.0185428
BICD1 bicaudal D homolog 1 (Drosophila) 0.0183291
CUX1 cut-like homeobox 1 0.0182796
SETX senataxin 0.0182189
DST dystonin 0.0181769
RAB7A RAB7A, member RAS oncogene family 0.0180964
NT5E 5'-nucleotidase, ecto (CD73) 0.0180629
TRAPPC9 trafficking protein particle complex 9 0.0179788

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.252512
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0964462
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0870778
TMSB10 thymosin beta 10 -0.0828293
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0806561
VIM vimentin -0.0792074
TFPI2 tissue factor pathway inhibitor 2 -0.0668733
PTMA prothymosin, alpha -0.0655006
RPLP0 ribosomal protein, large, P0 -0.0551122
RPL12 ribosomal protein L12 -0.0545595
TXNRD1 thioredoxin reductase 1 -0.0534205
OGA O-GlcNAcase -0.0524174
RPS21 ribosomal protein S21 -0.0511244
RPL37 ribosomal protein L37 -0.0494628
XPO1 exportin 1 -0.0494622
PHIP pleckstrin homology domain interacting protein -0.0466705
CSDE1 cold shock domain containing E1, RNA-binding -0.0465776
KDM3A lysine (K)-specific demethylase 3A -0.0461854
BBX bobby sox homolog (Drosophila) -0.0441988
EEF2 eukaryotic translation elongation factor 2 -0.0433022
NAP1L1 nucleosome assembly protein 1-like 1 -0.0428156
PGK1 phosphoglycerate kinase 1 -0.0422192
TPI1 triosephosphate isomerase 1 -0.0415704
RPL26 ribosomal protein L26 -0.0399337
RPLP1 ribosomal protein, large, P1 -0.0399134
RTN4 reticulon 4 -0.0395845
RPL35A ribosomal protein L35a -0.0389731
RPL19 ribosomal protein L19 -0.0377778
GOLGA4 golgin A4 -0.037508
MYL12B myosin, light chain 12B, regulatory -0.0374134
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0364529
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0362456
PFN1 profilin 1 -0.0356449
AHNAK AHNAK nucleoprotein -0.0346909
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.034682
RPS8 ribosomal protein S8 -0.0341209
RPL23 ribosomal protein L23 -0.0337246
KMT2A lysine (K)-specific methyltransferase 2A -0.0336769
KDM2A lysine (K)-specific demethylase 2A -0.0336179
H1-0 H1.0 linker histone -0.0335112
ZFR zinc finger RNA binding protein -0.0334175
RPL34 ribosomal protein L34 -0.0333865
CANX calnexin -0.0331572
RPS27 ribosomal protein S27 -0.032305
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0321889
UBE2H ubiquitin-conjugating enzyme E2H -0.0317028
RPL8 ribosomal protein L8 -0.0314773
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0304393
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0302398
RPS19 ribosomal protein S19 -0.0298475
LOC112694756 uncharaterized LOC112694756 -0.0295573
EIF1 eukaryotic translation initiation factor 1 -0.0295314
RPL32 ribosomal protein L32 -0.029496
SINHCAF SIN3-HDAC complex associated factor -0.0291995
TMEM165 transmembrane protein 165 -0.0291085
PREPL prolyl endopeptidase-like -0.0283687
PDIA4 protein disulfide isomerase family A, member 4 -0.0279811
RB1CC1 RB1-inducible coiled-coil 1 -0.0277062
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0276588
S100A6 S100 calcium binding protein A6 -0.0274352
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0273258
RPS27A ribosomal protein S27a -0.0272371
LDHB lactate dehydrogenase B -0.0271224
RPS6 ribosomal protein S6 -0.0270785
UBC ubiquitin C -0.0270769
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0267785
WASF2 WAS protein family, member 2 -0.0266917
LMAN1 lectin, mannose-binding, 1 -0.0264641
ZNF292 zinc finger protein 292 -0.0263934
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0260274
RPL11 ribosomal protein L11 -0.0254141
WSB1 WD repeat and SOCS box containing 1 -0.0252534
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0251717
WDR45B WD repeat domain 45B -0.0250796
KPNB1 karyopherin (importin) beta 1 -0.0247602
ANKRD12 ankyrin repeat domain 12 -0.0246571
HMGA1 high mobility group AT-hook 1 -0.0246538
RSF1 remodeling and spacing factor 1 -0.0245678
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0245372
FTL ferritin, light polypeptide -0.0244937
ATP5F1B ATP synthase F1 subunit beta -0.0244922
BSG basigin (Ok blood group) -0.0244789
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0243642
GARS1 glycyl-tRNA synthetase 1 -0.0241679
RPS24 ribosomal protein S24 -0.0241302
MIS18BP1 MIS18 binding protein 1 -0.0237144
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0236461
ZMYND8 zinc finger, MYND-type containing 8 -0.0236266
RPL35 ribosomal protein L35 -0.0235659
GNAS GNAS complex locus -0.0235179
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0233761
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0231881
CAVIN1 caveolae associated protein 1 -0.0229678
RAD21 RAD21 homolog (S. pombe) -0.0227392
RPS15 ribosomal protein S15 -0.0227318
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0226538
RPL4 ribosomal protein L4 -0.0226217
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0224952
NPEPPS aminopeptidase puromycin sensitive -0.0224871
BRWD3 bromodomain and WD repeat domain containing 3 -0.0223933