(R)-Verapamil (hydrochloride)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (R)-Verapamil (hydrochloride) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the (R)-Verapamil (hydrochloride)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 0.0945098
AFDN afadin, adherens junction formation factor 0.090606
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0795206
LOC102724023 ES1 protein homolog, mitochondrial 0.0781775
RIMKLB ribosomal modification protein rimK-like family member B 0.0779696
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0748039
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0679738
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.067144
EZR ezrin 0.0614101
SVIL supervillin 0.0609167
KRT18 keratin 18, type I 0.0591618
AREG amphiregulin 0.0582197
NDRG1 N-myc downstream regulated 1 0.0578701
RPS12 ribosomal protein S12 0.0567824
RPS8 ribosomal protein S8 0.056009
RPS3 ribosomal protein S3 0.0535561
LAMA4 laminin, alpha 4 0.0511646
RPS4X ribosomal protein S4, X-linked 0.0501202
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0500629
ARHGAP5 Rho GTPase activating protein 5 0.0499169
SH3KBP1 SH3-domain kinase binding protein 1 0.0489192
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0485068
ERRFI1 ERBB receptor feedback inhibitor 1 0.0481391
NAV2 neuron navigator 2 0.0469799
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0463403
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0441431
RPL37A ribosomal protein L37a 0.0432557
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0429431
CD44 CD44 molecule (Indian blood group) 0.040492
BCAR3 breast cancer anti-estrogen resistance 3 0.0401383
TJP1 tight junction protein 1 0.0400979
ARHGAP26 Rho GTPase activating protein 26 0.0399408
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0398936
EFNB2 ephrin-B2 0.039882
SOX9 SRY (sex determining region Y)-box 9 0.0397262
PLAUR plasminogen activator, urokinase receptor 0.0384914
BCL2L1 BCL2-like 1 0.0382453
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.0382229
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0374764
SMOC1 SPARC related modular calcium binding 1 0.0372759
SEPTIN9 septin 9 0.0371966
ACTN1 actinin, alpha 1 0.0348263
FUS FUS RNA binding protein 0.0345149
RPS17 ribosomal protein S17 0.0343215
SMYD3 SET and MYND domain containing 3 0.0338398
TRIO trio Rho guanine nucleotide exchange factor 0.0337113
LAMC2 laminin, gamma 2 0.0333728
LATS2 large tumor suppressor kinase 2 0.0331748
MYO1E myosin IE 0.0328448
MYO5B myosin VB 0.0328228
OXSR1 oxidative stress responsive 1 0.0321872
FLNB filamin B, beta 0.031858
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0309964
TSC22D1 TSC22 domain family, member 1 0.0305657
NACA nascent polypeptide-associated complex alpha subunit 0.0304268
FLNA filamin A, alpha 0.0299938
RNF213 ring finger protein 213 0.0299524
AKAP12 A kinase (PRKA) anchor protein 12 0.0297291
HSPA8 heat shock 70kDa protein 8 0.0295737
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0291605
CTBP2 C-terminal binding protein 2 0.0281843
ATP11A ATPase, class VI, type 11A 0.028094
RACK1 receptor for activated C kinase 1 0.0276654
TM4SF1 transmembrane 4 L six family member 1 0.0270385
RPL23 ribosomal protein L23 0.0268884
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0261141
JARID2 jumonji, AT rich interactive domain 2 0.0260781
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0260511
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0259847
DSPP dentin sialophosphoprotein 0.0259705
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0259535
MT2A metallothionein 2A 0.0256174
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0256038
RPL9 ribosomal protein L9 0.0255299
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0252343
DUSP10 dual specificity phosphatase 10 0.0250603
ZSWIM6 zinc finger, SWIM-type containing 6 0.024876
ZBTB38 zinc finger and BTB domain containing 38 0.0241843
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0239467
ATF3 activating transcription factor 3 0.0237824
PCLO piccolo presynaptic cytomatrix protein 0.0235093
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.02349
RPL36 ribosomal protein L36 0.0232118
EHF ets homologous factor 0.0231029
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.022709
PRELID2 PRELI domain containing 2 0.021955
DUSP5 dual specificity phosphatase 5 0.021883
IRS2 insulin receptor substrate 2 0.0216267
SQSTM1 sequestosome 1 0.0216261
PTPRE protein tyrosine phosphatase, receptor type, E 0.0214996
PPARD peroxisome proliferator-activated receptor delta 0.0214302
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0213792
CSNK1A1 casein kinase 1, alpha 1 0.0212725
MX1 MX dynamin-like GTPase 1 0.0208798
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0208258
KLF12 Kruppel-like factor 12 0.0207279
FMNL2 formin-like 2 0.0206992
GPHN gephyrin 0.020593
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.0205571
TGM2 transglutaminase 2 0.0204422

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.279309
PTMA prothymosin, alpha -0.129795
ANXA2 annexin A2 -0.101582
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.101098
TMSB4X thymosin beta 4, X-linked -0.100832
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0949113
LOC112694756 uncharaterized LOC112694756 -0.0879812
FTH1 ferritin, heavy polypeptide 1 -0.0843808
KRT17 keratin 17, type I -0.0808575
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0801095
CANX calnexin -0.0747005
AHNAK AHNAK nucleoprotein -0.0693707
F3 coagulation factor III (thromboplastin, tissue factor) -0.0689363
TMSB10 thymosin beta 10 -0.0660839
MUC4 mucin 4, cell surface associated -0.0651905
GOLGA4 golgin A4 -0.0635248
B2M beta-2-microglobulin -0.0634235
POTEF POTE ankyrin domain family, member F -0.0626746
TPM4 tropomyosin 4 -0.0614548
RIOK3 RIO kinase 3 -0.0602085
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.059308
RPLP1 ribosomal protein, large, P1 -0.0589261
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0587853
VCL vinculin -0.056393
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0552594
RPS6 ribosomal protein S6 -0.0551415
LAMB3 laminin, beta 3 -0.0535547
RPL35A ribosomal protein L35a -0.0530908
DSG2 desmoglein 2 -0.0511227
FAM3C family with sequence similarity 3, member C -0.0508674
DLG1 discs, large homolog 1 (Drosophila) -0.0504108
PDLIM5 PDZ and LIM domain 5 -0.049845
TAPBP TAP binding protein (tapasin) -0.0495858
DAPK1 death-associated protein kinase 1 -0.0468599
ZFAND3 zinc finger, AN1-type domain 3 -0.0460086
CAV1 caveolin 1, caveolae protein, 22kDa -0.0459744
EGR1 early growth response 1 -0.0452377
CD2AP CD2-associated protein -0.0447052
PDIA3 protein disulfide isomerase family A, member 3 -0.0434466
KRT8 keratin 8, type II -0.0431029
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0411582
VEGFA vascular endothelial growth factor A -0.0411501
RAD21 RAD21 homolog (S. pombe) -0.0406922
FOSL1 FOS-like antigen 1 -0.0403919
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0401702
C6ORF132 chromosome 6 open reading frame 132 -0.0398861
UGCG UDP-glucose ceramide glucosyltransferase -0.0396708
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0393066
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0387107
SYT14 synaptotagmin XIV -0.0386384
DPYD dihydropyrimidine dehydrogenase -0.0385081
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0378786
S100A6 S100 calcium binding protein A6 -0.0369573
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0367046
BRD4 bromodomain containing 4 -0.036621
MBNL2 muscleblind-like splicing regulator 2 -0.0359602
ANLN anillin, actin binding protein -0.0359352
ASPH aspartate beta-hydroxylase -0.0357343
CD47 CD47 molecule -0.0353143
EIF1 eukaryotic translation initiation factor 1 -0.0348081
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0347393
PHF3 PHD finger protein 3 -0.0347311
MYO6 myosin VI -0.0346957
SETD5 SET domain containing 5 -0.0341043
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0340228
PKM pyruvate kinase, muscle -0.0340213
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0335243
SORBS2 sorbin and SH3 domain containing 2 -0.0332949
RPL19 ribosomal protein L19 -0.0329121
PICALM phosphatidylinositol binding clathrin assembly protein -0.032881
RPS13 ribosomal protein S13 -0.0323298
H1-0 H1.0 linker histone -0.0322985
RSF1 remodeling and spacing factor 1 -0.0318968
ZNF207 zinc finger protein 207 -0.0315176
DIAPH3 diaphanous-related formin 3 -0.0313538
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0311987
TSC22D2 TSC22 domain family, member 2 -0.0308054
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.030237
CXADR coxsackie virus and adenovirus receptor -0.0301657
UBE2H ubiquitin-conjugating enzyme E2H -0.0301514
ZNF148 zinc finger protein 148 -0.029986
PGK1 phosphoglycerate kinase 1 -0.0299767
NT5C2 5'-nucleotidase, cytosolic II -0.0299322
ARHGAP18 Rho GTPase activating protein 18 -0.0298498
LY6E lymphocyte antigen 6 complex, locus E -0.0298371
ZNF609 zinc finger protein 609 -0.0297946
RHOA ras homolog family member A -0.0297217
TMEM123 transmembrane protein 123 -0.0295077
SMC4 structural maintenance of chromosomes 4 -0.0294639
SRP54 signal recognition particle 54kDa -0.0294554
PERP PERP, TP53 apoptosis effector -0.0294072
RCOR1 REST corepressor 1 -0.0293889
ATP5F1B ATP synthase F1 subunit beta -0.0291084
IGFBP3 insulin-like growth factor binding protein 3 -0.0289233
PLSCR1 phospholipid scramblase 1 -0.0288287
AKAP9 A kinase (PRKA) anchor protein 9 -0.0288144
RPL34 ribosomal protein L34 -0.0287676
ACTN4 actinin, alpha 4 -0.028673
KLHL24 kelch-like family member 24 -0.028571
HLA-E major histocompatibility complex, class I, E -0.0283597