(R)-Verapamil (hydrochloride)_RPMI-7951 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (R)-Verapamil (hydrochloride) perturbation in RPMI-7951 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the (R)-Verapamil (hydrochloride)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.0786742
MT2A metallothionein 2A 0.0739448
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0456861
ANGPTL4 angiopoietin-like 4 0.0451415
ERRFI1 ERBB receptor feedback inhibitor 1 0.0416439
RPS12 ribosomal protein S12 0.0357488
RPS3 ribosomal protein S3 0.0278938
RPL36 ribosomal protein L36 0.0274155
RPL26 ribosomal protein L26 0.0269187
RPS8 ribosomal protein S8 0.026891
RPL23 ribosomal protein L23 0.0266403
WWTR1 WW domain containing transcription regulator 1 0.0264885
RPS17 ribosomal protein S17 0.0264764
TPT1 tumor protein, translationally-controlled 1 0.0236586
SVIL supervillin 0.0229308
PRRC2C proline-rich coiled-coil 2C 0.0220143
HMGA2 high mobility group AT-hook 2 0.0207063
FLNB filamin B, beta 0.0206575
RPL37A ribosomal protein L37a 0.0188962
IFI6 interferon, alpha-inducible protein 6 0.0183009
IGF2 insulin-like growth factor 2 0.0174296
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0174044
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0172639
FAT1 FAT atypical cadherin 1 0.0168272
IFI44L interferon-induced protein 44-like 0.016243
EIF1 eukaryotic translation initiation factor 1 0.0157062
HSPA8 heat shock 70kDa protein 8 0.0156275
RPL32 ribosomal protein L32 0.0150533
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0149199
ARRDC3 arrestin domain containing 3 0.014879
NUMBL numb homolog (Drosophila)-like 0.0143659
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0140419
RPL5 ribosomal protein L5 0.0139123
RPS4X ribosomal protein S4, X-linked 0.0139013
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0138732
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0137829
PTPRD protein tyrosine phosphatase, receptor type, D 0.0137065
SLK STE20-like kinase 0.0133554
AFDN afadin, adherens junction formation factor 0.0130995
RPS27 ribosomal protein S27 0.0128441
SMAD3 SMAD family member 3 0.0128212
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0123407
RPL36A ribosomal protein L36a 0.012122
RPS6 ribosomal protein S6 0.0119936
RPS2 ribosomal protein S2 0.011828
SQSTM1 sequestosome 1 0.0118197
MT1E metallothionein 1E 0.0117972
SEPTIN9 septin 9 0.0115072
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0114985
PHF14 PHD finger protein 14 0.0114954
CEP290 centrosomal protein 290kDa 0.0114645
NRIP1 nuclear receptor interacting protein 1 0.0114551
SCAPER S-phase cyclin A-associated protein in the ER 0.0112608
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0111735
ITSN2 intersectin 2 0.0111644
SMYD3 SET and MYND domain containing 3 0.0111146
HELZ2 helicase with zinc finger 2, transcriptional coactivator 0.0110453
CELF1 CUGBP, Elav-like family member 1 0.0109773
SPAG9 sperm associated antigen 9 0.0109638
CCL5 chemokine (C-C motif) ligand 5 0.010727
H2AC6 H2A clustered histone 6 0.0107239
NFE2L1 nuclear factor, erythroid 2-like 1 0.0106123
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.0105918
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0105719
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0105666
RACK1 receptor for activated C kinase 1 0.0104792
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0103602
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0102316
PMP22 peripheral myelin protein 22 0.0101379
KLF6 Kruppel-like factor 6 0.0101121
WNT9A wingless-type MMTV integration site family, member 9A 0.0101036
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0100957
RPS15 ribosomal protein S15 0.0100271
SOX9 SRY (sex determining region Y)-box 9 0.00991422
ZMIZ1 zinc finger, MIZ-type containing 1 0.00989438
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.00986191
PLEC plectin 0.00971295
EZR ezrin 0.00958792
ZC3H12B zinc finger CCCH-type containing 12B 0.00948163
SETBP1 SET binding protein 1 0.00942695
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.00939739
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.00931958
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.00931429
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.00919112
TSC22D1 TSC22 domain family, member 1 0.00914579
OXSR1 oxidative stress responsive 1 0.00913714
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.00909996
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.00906477
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.00898678
PRELID2 PRELI domain containing 2 0.00892929
PRKN parkin RBR E3 ubiquitin protein ligase 0.00890807
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.00883264
EIF4H eukaryotic translation initiation factor 4H 0.00881112
MBNL1 muscleblind-like splicing regulator 1 0.00871755
TRIM25 tripartite motif containing 25 0.00870195
APP amyloid beta (A4) precursor protein 0.00864425
BCL2L1 BCL2-like 1 0.00863377
FBXL3 F-box and leucine-rich repeat protein 3 0.00857316
PRRC2B proline-rich coiled-coil 2B 0.00854709
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) 0.00837177

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.287928
FN1 fibronectin 1 -0.226798
COL1A2 collagen, type I, alpha 2 -0.173672
TIMP3 TIMP metallopeptidase inhibitor 3 -0.137988
COL1A1 collagen, type I, alpha 1 -0.119441
POTEF POTE ankyrin domain family, member F -0.103887
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.099849
CDH13 cadherin 13 -0.0974156
FNDC3B fibronectin type III domain containing 3B -0.0857722
COL6A1 collagen, type VI, alpha 1 -0.0834074
INHBA inhibin, beta A -0.0700486
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.06979
COL6A2 collagen, type VI, alpha 2 -0.0682155
B2M beta-2-microglobulin -0.0611908
PDIA3 protein disulfide isomerase family A, member 3 -0.0611786
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0595383
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0593323
TPM4 tropomyosin 4 -0.0579783
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0578868
TMSB10 thymosin beta 10 -0.0548707
GOLGA4 golgin A4 -0.0534596
ZEB1 zinc finger E-box binding homeobox 1 -0.052595
FRMD4A FERM domain containing 4A -0.0525501
MMP12 matrix metallopeptidase 12 -0.052185
PGK1 phosphoglycerate kinase 1 -0.0516868
TPM1 tropomyosin 1 (alpha) -0.0512325
RAB7A RAB7A, member RAS oncogene family -0.0494774
TNS3 tensin 3 -0.0490133
TENT5A terminal nucleotidyltransferase 5A -0.0465762
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0450892
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0444232
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.044174
DLG1 discs, large homolog 1 (Drosophila) -0.0434853
PTPRG protein tyrosine phosphatase, receptor type, G -0.0426056
NAV1 neuron navigator 1 -0.0416856
FTL ferritin, light polypeptide -0.0409939
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0403157
PTMA prothymosin, alpha -0.040184
S100A6 S100 calcium binding protein A6 -0.0392501
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0383424
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0371172
SETD5 SET domain containing 5 -0.0367064
F3 coagulation factor III (thromboplastin, tissue factor) -0.0365842
ZMYND8 zinc finger, MYND-type containing 8 -0.0365756
NRP1 neuropilin 1 -0.0365373
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0365042
GLIS3 GLIS family zinc finger 3 -0.036236
GNAS GNAS complex locus -0.03607
CD109 CD109 molecule -0.035196
ITGA1 integrin, alpha 1 -0.034797
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0343208
DSTN destrin (actin depolymerizing factor) -0.0340108
RRBP1 ribosome binding protein 1 -0.0336539
CALD1 caldesmon 1 -0.0330278
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0329668
MYH9 myosin, heavy chain 9, non-muscle -0.0327441
ITGA11 integrin, alpha 11 -0.0323538
PSD3 pleckstrin and Sec7 domain containing 3 -0.0321117
JARID2 jumonji, AT rich interactive domain 2 -0.0320445
TNNC1 troponin C type 1 (slow) -0.0310716
MMP2 matrix metallopeptidase 2 -0.0307173
PKM pyruvate kinase, muscle -0.0305501
VCAN versican -0.0301396
NBAS neuroblastoma amplified sequence -0.0300552
LOC112694756 uncharaterized LOC112694756 -0.0298539
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.029676
ZBTB20 zinc finger and BTB domain containing 20 -0.0296739
RAB1A RAB1A, member RAS oncogene family -0.0288837
CTSB cathepsin B -0.0287744
LPP LIM domain containing preferred translocation partner in lipoma -0.0286431
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0286428
APCDD1L adenomatosis polyposis coli down-regulated 1-like -0.0286363
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0282067
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0275609
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0272354
MEF2A myocyte enhancer factor 2A -0.0272036
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0270086
CAPZB capping protein (actin filament) muscle Z-line, beta -0.0270016
ARL4C ADP-ribosylation factor-like 4C -0.0269969
EML5 echinoderm microtubule associated protein like 5 -0.0267225
ADAM12 ADAM metallopeptidase domain 12 -0.0267159
FAM20C family with sequence similarity 20, member C -0.0266912
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0265883
MSN moesin -0.0265323
THBS1 thrombospondin 1 -0.0265172
VCL vinculin -0.0264559
TMEM178B transmembrane protein 178B -0.0259048
CADM1 cell adhesion molecule 1 -0.0258835
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0256813
LOXL2 lysyl oxidase-like 2 -0.0256135
STC1 stanniocalcin 1 -0.0254965
LPAR1 lysophosphatidic acid receptor 1 -0.0251174
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0250709
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) -0.0250608
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0249034
TMEM263 transmembrane protein 263 -0.0246437
HDLBP high density lipoprotein binding protein -0.0245923
EXT1 exostosin glycosyltransferase 1 -0.0243589
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.024151
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0239506