(R)-Verapamil (hydrochloride)_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (R)-Verapamil (hydrochloride) perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the (R)-Verapamil (hydrochloride)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.127536
GLIS3 GLIS family zinc finger 3 0.117667
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.115138
AKAP12 A kinase (PRKA) anchor protein 12 0.108329
HDAC9 histone deacetylase 9 0.107334
NDRG1 N-myc downstream regulated 1 0.0974921
HMGA2 high mobility group AT-hook 2 0.0902533
COL6A3 collagen, type VI, alpha 3 0.0818717
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0781907
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0647457
MT2A metallothionein 2A 0.0639208
SEPTIN9 septin 9 0.0636838
VCAN versican 0.0633982
LDHA lactate dehydrogenase A 0.0611996
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0598716
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0597885
TRIO trio Rho guanine nucleotide exchange factor 0.0597849
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0595302
ZBTB38 zinc finger and BTB domain containing 38 0.0587106
HLA-B major histocompatibility complex, class I, B 0.0565944
RPS4X ribosomal protein S4, X-linked 0.0557357
GPC6 glypican 6 0.0547344
INTS6 integrator complex subunit 6 0.0546414
RPS12 ribosomal protein S12 0.0539652
FRMD4A FERM domain containing 4A 0.0507307
TPT1 tumor protein, translationally-controlled 1 0.0476923
ASPH aspartate beta-hydroxylase 0.0475052
STC1 stanniocalcin 1 0.0459897
SQSTM1 sequestosome 1 0.045835
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0451827
CDH13 cadherin 13 0.0443348
ZSWIM6 zinc finger, SWIM-type containing 6 0.0431217
TMEM132D transmembrane protein 132D 0.0427329
SFTPA2 surfactant protein A2 0.0426211
NAV1 neuron navigator 1 0.0420934
ZMIZ1 zinc finger, MIZ-type containing 1 0.0406276
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0405993
COL5A1 collagen, type V, alpha 1 0.0400387
EGFR epidermal growth factor receptor 0.0400386
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0399764
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0389832
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0387819
RPL37A ribosomal protein L37a 0.0384083
EFNA5 ephrin-A5 0.0371218
IER3 immediate early response 3 0.0368865
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0352714
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0346786
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0331754
INHBA inhibin, beta A 0.0328626
BICC1 BicC family RNA binding protein 1 0.0326195
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0325186
FBXL7 F-box and leucine-rich repeat protein 7 0.0319859
BPTF bromodomain PHD finger transcription factor 0.0317656
MACF1 microtubule-actin crosslinking factor 1 0.0306936
MORF4L2 mortality factor 4 like 2 0.030693
RAD51B RAD51 paralog B 0.0303045
TGFBI transforming growth factor, beta-induced, 68kDa 0.0289407
ARHGAP22 Rho GTPase activating protein 22 0.0286974
DUSP10 dual specificity phosphatase 10 0.0284791
EPAS1 endothelial PAS domain protein 1 0.0283635
HLA-A major histocompatibility complex, class I, A 0.0282165
SOX9 SRY (sex determining region Y)-box 9 0.0282028
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0276455
PMEPA1 prostate transmembrane protein, androgen induced 1 0.027591
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0273346
RPS3 ribosomal protein S3 0.027008
RNF213 ring finger protein 213 0.0268067
EXT1 exostosin glycosyltransferase 1 0.0266487
WWOX WW domain containing oxidoreductase 0.0264428
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0263656
TBC1D22A TBC1 domain family, member 22A 0.0260067
AFF3 AF4/FMR2 family, member 3 0.0259914
FLNB filamin B, beta 0.025629
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0254112
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0253334
SVIL supervillin 0.0251055
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0247998
EGR1 early growth response 1 0.0247682
FMNL2 formin-like 2 0.0243736
FTL ferritin, light polypeptide 0.0243215
CD44 CD44 molecule (Indian blood group) 0.0242701
ATXN1 ataxin 1 0.0241879
TNS3 tensin 3 0.0239215
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0236133
TGM2 transglutaminase 2 0.0234832
PRELID2 PRELI domain containing 2 0.0231646
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0228609
UBASH3B ubiquitin associated and SH3 domain containing B 0.0227343
MLPH melanophilin 0.0220021
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0219335
IFITM3 interferon induced transmembrane protein 3 0.0216829
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.021615
DOCK5 dedicator of cytokinesis 5 0.0215392
ENO2 enolase 2 (gamma, neuronal) 0.0214396
ZHX2 zinc fingers and homeoboxes 2 0.0213816
ANGPTL4 angiopoietin-like 4 0.0212839
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0212262
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0209268
RUNX1 runt-related transcription factor 1 0.0208527
PTH2R parathyroid hormone 2 receptor 0.0208437

decreased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial -0.253643
NAMPT nicotinamide phosphoribosyltransferase -0.178971
FN1 fibronectin 1 -0.156129
UGCG UDP-glucose ceramide glucosyltransferase -0.095
FTH1 ferritin, heavy polypeptide 1 -0.0934477
MYH9 myosin, heavy chain 9, non-muscle -0.0689596
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0678914
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0658157
PGK1 phosphoglycerate kinase 1 -0.0595687
RTN4 reticulon 4 -0.059383
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0547057
OGA O-GlcNAcase -0.054142
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0534025
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0530863
ANXA2 annexin A2 -0.0516363
CADM1 cell adhesion molecule 1 -0.0477073
LOC112694756 uncharaterized LOC112694756 -0.0474815
ELL2 elongation factor, RNA polymerase II, 2 -0.0470876
FNDC3B fibronectin type III domain containing 3B -0.0447825
UBC ubiquitin C -0.0445519
VIM vimentin -0.0443288
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.044047
ZNF292 zinc finger protein 292 -0.0436781
GOLGA4 golgin A4 -0.0433285
TPM4 tropomyosin 4 -0.0432233
ANLN anillin, actin binding protein -0.0421261
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0416984
RBM39 RNA binding motif protein 39 -0.0413229
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0411426
CENPF centromere protein F, 350/400kDa -0.0409442
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0406653
WTAP Wilms tumor 1 associated protein -0.04026
SBF2 SET binding factor 2 -0.0386416
THBS1 thrombospondin 1 -0.0386318
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0365772
NT5C2 5'-nucleotidase, cytosolic II -0.0362015
LCORL ligand dependent nuclear receptor corepressor-like -0.035669
CANX calnexin -0.0354867
MKI67 marker of proliferation Ki-67 -0.0353993
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.034839
AHNAK AHNAK nucleoprotein -0.0338556
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0338497
EEF1G eukaryotic translation elongation factor 1 gamma -0.0337016
TMSB4X thymosin beta 4, X-linked -0.0335204
PTMA prothymosin, alpha -0.0335046
TAPBP TAP binding protein (tapasin) -0.0330036
TXNRD1 thioredoxin reductase 1 -0.0323004
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0320721
GNAS GNAS complex locus -0.0319822
RB1CC1 RB1-inducible coiled-coil 1 -0.0316057
KDM3A lysine (K)-specific demethylase 3A -0.0312807
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0311278
MATR3 matrin 3 -0.0310783
TNIP1 TNFAIP3 interacting protein 1 -0.0310681
CKAP5 cytoskeleton associated protein 5 -0.03103
POTEF POTE ankyrin domain family, member F -0.0309342
DEK DEK proto-oncogene -0.0308278
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0306699
KIF4A kinesin family member 4A -0.0303444
TMEM123 transmembrane protein 123 -0.0303444
ZFAND3 zinc finger, AN1-type domain 3 -0.0302246
DIAPH3 diaphanous-related formin 3 -0.0296247
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0296223
ACTG1 actin gamma 1 -0.0295275
CDCP1 CUB domain containing protein 1 -0.0291934
SPAG9 sperm associated antigen 9 -0.0289851
DENND5A DENN/MADD domain containing 5A -0.0289178
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0289102
EEF2 eukaryotic translation elongation factor 2 -0.0284015
MARCHF6 membrane associated ring-CH-type finger 6 -0.0283984
TSC22D2 TSC22 domain family, member 2 -0.0282312
SNX9 sorting nexin 9 -0.0277904
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.027705
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0270352
PDIA3 protein disulfide isomerase family A, member 3 -0.026927
ATP13A3 ATPase type 13A3 -0.0268165
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0266177
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0264667
KPNB1 karyopherin (importin) beta 1 -0.0264365
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0263991
RHOA ras homolog family member A -0.0263332
TMEM41B transmembrane protein 41B -0.0263225
SMC4 structural maintenance of chromosomes 4 -0.0260041
TPX2 TPX2, microtubule-associated -0.0258399
VCL vinculin -0.025041
RAD21 RAD21 homolog (S. pombe) -0.0247407
ARF4 ADP-ribosylation factor 4 -0.0246446
USP9X ubiquitin specific peptidase 9, X-linked -0.0245774
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0244105
PTBP3 polypyrimidine tract binding protein 3 -0.0242188
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0241984
NPEPPS aminopeptidase puromycin sensitive -0.02401
YBX1 Y box binding protein 1 -0.0236801
ICAM1 intercellular adhesion molecule 1 -0.023607
MSN moesin -0.0235491
BRWD3 bromodomain and WD repeat domain containing 3 -0.0235466
TM9SF3 transmembrane 9 superfamily member 3 -0.0234727
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0232041
OPTN optineurin -0.0231359
HDLBP high density lipoprotein binding protein -0.0226927