(R)-Verapamil (hydrochloride)_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (R)-Verapamil (hydrochloride) perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the (R)-Verapamil (hydrochloride)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.148717
ERRFI1 ERBB receptor feedback inhibitor 1 0.0706155
EGFR epidermal growth factor receptor 0.0327502
FNDC3A fibronectin type III domain containing 3A 0.0271333
TXNRD1 thioredoxin reductase 1 0.0261582
IGF2 insulin-like growth factor 2 0.0257576
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0254169
KYNU kynureninase 0.0253355
PDLIM5 PDZ and LIM domain 5 0.0244204
PRKN parkin RBR E3 ubiquitin protein ligase 0.0238973
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0235248
NCOA7 nuclear receptor coactivator 7 0.0230729
AKAP12 A kinase (PRKA) anchor protein 12 0.022991
SETBP1 SET binding protein 1 0.0227617
WWTR1 WW domain containing transcription regulator 1 0.0226484
PDE4D phosphodiesterase 4D, cAMP-specific 0.0226024
FHIT fragile histidine triad 0.0220521
GTF2IRD1 GTF2I repeat domain containing 1 0.0220189
SOX5 SRY (sex determining region Y)-box 5 0.0219507
TSC22D1 TSC22 domain family, member 1 0.0212297
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0206049
SMAD3 SMAD family member 3 0.0204806
USP34 ubiquitin specific peptidase 34 0.0202293
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0201909
ATXN1 ataxin 1 0.0200743
SEPTIN9 septin 9 0.0198102
NPAS2 neuronal PAS domain protein 2 0.0193783
ARHGAP24 Rho GTPase activating protein 24 0.0192924
GPC6 glypican 6 0.019147
TCF12 transcription factor 12 0.0184925
ZMIZ1 zinc finger, MIZ-type containing 1 0.0183286
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0182867
EXT1 exostosin glycosyltransferase 1 0.0182398
TIMP3 TIMP metallopeptidase inhibitor 3 0.0179443
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0176749
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0176609
ACTN1 actinin, alpha 1 0.0171793
PTPRM protein tyrosine phosphatase, receptor type, M 0.0170199
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.016957
EFNA5 ephrin-A5 0.0168489
GCC2 GRIP and coiled-coil domain containing 2 0.0167153
EXOC4 exocyst complex component 4 0.0166672
UTRN utrophin 0.0166472
HMGA2 high mobility group AT-hook 2 0.0165935
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0164403
WNT5A wingless-type MMTV integration site family, member 5A 0.016401
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0163865
ALK anaplastic lymphoma receptor tyrosine kinase 0.0162576
SMC4 structural maintenance of chromosomes 4 0.0161303
RBBP6 retinoblastoma binding protein 6 0.0160373
ATM ATM serine/threonine kinase 0.0159744
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0157724
NRIP1 nuclear receptor interacting protein 1 0.0155998
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.015421
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0153537
CXCL8 chemokine (C-X-C motif) ligand 8 0.015233
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0152069
RABGAP1L RAB GTPase activating protein 1-like 0.0150373
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0146619
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0146611
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0146045
FAM20C family with sequence similarity 20, member C 0.0145705
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0145297
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0145207
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0144011
SPRED2 sprouty-related, EVH1 domain containing 2 0.0143358
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0140811
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.0139177
THSD4 thrombospondin, type I, domain containing 4 0.0136829
RPS2 ribosomal protein S2 0.0136193
PDS5A PDS5 cohesin associated factor A 0.0136025
AFDN afadin, adherens junction formation factor 0.0135374
NIN ninein (GSK3B interacting protein) 0.0135343
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0135
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0134732
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.0134631
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0134002
HDAC4 histone deacetylase 4 0.0133493
MPRIP myosin phosphatase Rho interacting protein 0.0133364
MYH9 myosin, heavy chain 9, non-muscle 0.0132962
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.013281
RPRD1B regulation of nuclear pre-mRNA domain containing 1B 0.0132082
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0131394
IRAK2 interleukin-1 receptor-associated kinase 2 0.0130605
STAU2 staufen double-stranded RNA binding protein 2 0.0130582
RPS17 ribosomal protein S17 0.0130297
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0129321
EEA1 early endosome antigen 1 0.0129319
DYNC2I1 dynein 2 intermediate chain 1 0.012921
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0129183
ZBTB20 zinc finger and BTB domain containing 20 0.0129153
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0129042
CDH13 cadherin 13 0.0128593
AHR aryl hydrocarbon receptor 0.0126699
NABP1 nucleic acid binding protein 1 0.0126434
BCAS3 breast carcinoma amplified sequence 3 0.0126364
CCDC14 coiled-coil domain containing 14 0.0125802
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0125598
CLIP1 CAP-GLY domain containing linker protein 1 0.0125129
PID1 phosphotyrosine interaction domain containing 1 0.0124965

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.252499
TMSB10 thymosin beta 10 -0.193336
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.191691
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.150113
MT2A metallothionein 2A -0.144024
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.126408
B2M beta-2-microglobulin -0.124163
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.115347
COL1A2 collagen, type I, alpha 2 -0.113035
MT1X metallothionein 1X -0.10042
HLA-B major histocompatibility complex, class I, B -0.0968435
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0904992
TGFBI transforming growth factor, beta-induced, 68kDa -0.0888575
F3 coagulation factor III (thromboplastin, tissue factor) -0.0868362
COL1A1 collagen, type I, alpha 1 -0.084631
PTMA prothymosin, alpha -0.0820564
FTL ferritin, light polypeptide -0.0762085
MAP1B microtubule-associated protein 1B -0.075144
POTEF POTE ankyrin domain family, member F -0.0723438
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0692881
COL6A3 collagen, type VI, alpha 3 -0.0689467
FTH1 ferritin, heavy polypeptide 1 -0.0676311
CALD1 caldesmon 1 -0.064133
PRSS23 protease, serine, 23 -0.0635102
UBC ubiquitin C -0.0608016
CALR calreticulin -0.0572264
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0564974
LOC112694756 uncharaterized LOC112694756 -0.0564412
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0562153
ENO1 enolase 1, (alpha) -0.0560087
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0543228
CANX calnexin -0.053725
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0519092
RTN4 reticulon 4 -0.0515301
ANXA2 annexin A2 -0.0506678
HLA-A major histocompatibility complex, class I, A -0.0501196
HLA-C major histocompatibility complex, class I, C -0.0495756
ELL2 elongation factor, RNA polymerase II, 2 -0.0486044
RRBP1 ribosome binding protein 1 -0.0482747
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0482283
PTN pleiotrophin -0.0469493
TENT5A terminal nucleotidyltransferase 5A -0.0465109
COL6A1 collagen, type VI, alpha 1 -0.0464938
EIF1 eukaryotic translation initiation factor 1 -0.0462158
CALU calumenin -0.0458968
H3-3B H3.3 histone B -0.0457778
TPM4 tropomyosin 4 -0.0452105
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0435246
RAB1A RAB1A, member RAS oncogene family -0.0422226
PKM pyruvate kinase, muscle -0.0419965
GOLGA4 golgin A4 -0.0419671
CCNI cyclin I -0.0416245
UGCG UDP-glucose ceramide glucosyltransferase -0.0397849
GLG1 golgi glycoprotein 1 -0.0396597
S100A6 S100 calcium binding protein A6 -0.0393278
LOX lysyl oxidase -0.0392629
TPM1 tropomyosin 1 (alpha) -0.0392512
LMNA lamin A/C -0.0388218
PGK1 phosphoglycerate kinase 1 -0.0387359
ANKRD11 ankyrin repeat domain 11 -0.0382426
COL6A2 collagen, type VI, alpha 2 -0.0380695
SDC4 syndecan 4 -0.0380297
S100A9 S100 calcium binding protein A9 -0.0377127
SEPTIN7 septin 7 -0.0375827
PFN1 profilin 1 -0.0374867
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0374765
PDIA3 protein disulfide isomerase family A, member 3 -0.0374415
AHNAK AHNAK nucleoprotein -0.0374077
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0373553
KMT2E lysine (K)-specific methyltransferase 2E -0.0372646
TRA2A transformer 2 alpha homolog (Drosophila) -0.036183
GARS1 glycyl-tRNA synthetase 1 -0.036127
VDAC1 voltage-dependent anion channel 1 -0.0360367
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0359253
ADM adrenomedullin -0.035601
SETD5 SET domain containing 5 -0.03554
MATR3 matrin 3 -0.035533
BSG basigin (Ok blood group) -0.0354467
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.034863
TMSB4X thymosin beta 4, X-linked -0.0347571
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0342365
HOOK2 hook microtubule-tethering protein 2 -0.0338445
RPL34 ribosomal protein L34 -0.0336115
WASF2 WAS protein family, member 2 -0.0331145
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0327514
LMAN1 lectin, mannose-binding, 1 -0.0325071
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.031956
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0317604
GNAS GNAS complex locus -0.031623
RPS8 ribosomal protein S8 -0.0306391
PDIA6 protein disulfide isomerase family A, member 6 -0.0305218
IGFBP7 insulin-like growth factor binding protein 7 -0.0290411
ANKRD17 ankyrin repeat domain 17 -0.0289455
CTSB cathepsin B -0.0288715
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0288092
TAGLN2 transgelin 2 -0.0286427
SRP54 signal recognition particle 54kDa -0.028607
ZNF395 zinc finger protein 395 -0.0284032
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0281747
HDLBP high density lipoprotein binding protein -0.0281058