(R)-Verapamil (hydrochloride)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (R)-Verapamil (hydrochloride) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the (R)-Verapamil (hydrochloride)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 0.0576818
NTN4 netrin 4 0.0429726
MT2A metallothionein 2A 0.0388828
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0383386
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0374664
NPAS2 neuronal PAS domain protein 2 0.0350071
NDRG1 N-myc downstream regulated 1 0.0329633
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0326999
PRRC2C proline-rich coiled-coil 2C 0.0303258
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0285344
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0283162
SVIL supervillin 0.0254016
VEGFC vascular endothelial growth factor C 0.0243876
SPRED2 sprouty-related, EVH1 domain containing 2 0.0237089
ANKRD28 ankyrin repeat domain 28 0.0236685
ATXN1 ataxin 1 0.0235492
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0234134
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0233663
WWTR1 WW domain containing transcription regulator 1 0.0233631
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0233275
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.0230772
GPATCH2L G patch domain containing 2-like 0.0229173
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.02254
SMYD3 SET and MYND domain containing 3 0.0222621
DUSP5 dual specificity phosphatase 5 0.0219732
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0209927
CD44 CD44 molecule (Indian blood group) 0.0206158
NALF1 NALCN channel auxiliary factor 1 0.0201909
LTBP1 latent transforming growth factor beta binding protein 1 0.0194327
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0192105
SON SON DNA binding protein 0.0191542
RASAL2 RAS protein activator like 2 0.0189528
ELL2 elongation factor, RNA polymerase II, 2 0.0187334
SMAD3 SMAD family member 3 0.0187321
PHC2 polyhomeotic homolog 2 (Drosophila) 0.018553
ACTN1 actinin, alpha 1 0.0185455
AKAP13 A kinase (PRKA) anchor protein 13 0.0176589
FOXP1 forkhead box P1 0.0176525
FLNA filamin A, alpha 0.017364
MYADM myeloid-associated differentiation marker 0.0168799
DUSP10 dual specificity phosphatase 10 0.0168549
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0167609
SHB Src homology 2 domain containing adaptor protein B 0.0165804
RNASEH2A ribonuclease H2, subunit A 0.0163881
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.016357
PTPRD protein tyrosine phosphatase, receptor type, D 0.0162883
RPS12 ribosomal protein S12 0.0162078
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0161666
TSC22D1 TSC22 domain family, member 1 0.0160445
AREG amphiregulin 0.0159786
ERBIN erbb2 interacting protein 0.0159474
SEPTIN9 septin 9 0.0158106
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.015771
SYNJ2 synaptojanin 2 0.0157586
JAG1 jagged 1 0.015638
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.015625
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0155828
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.015515
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0154958
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0153875
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.01513
IRS2 insulin receptor substrate 2 0.0149771
PALLD palladin, cytoskeletal associated protein 0.0149115
PCM1 pericentriolar material 1 0.0146566
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0145726
RPS2 ribosomal protein S2 0.0144727
ENO2 enolase 2 (gamma, neuronal) 0.0144567
PELO pelota homolog (Drosophila) 0.014339
CHD1 chromodomain helicase DNA binding protein 1 0.0142872
MEF2D myocyte enhancer factor 2D 0.014279
NOTCH2 notch 2 0.0142571
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0142079
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0140759
RICTOR RPTOR independent companion of MTOR, complex 2 0.0138793
PLAUR plasminogen activator, urokinase receptor 0.0138043
KIAA1217 KIAA1217 0.0135698
MBNL1 muscleblind-like splicing regulator 1 0.013473
IFI44L interferon-induced protein 44-like 0.0134127
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0134069
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0133846
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0133783
NRP1 neuropilin 1 0.0132949
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0131475
BCL2L1 BCL2-like 1 0.0127767
DOCK5 dedicator of cytokinesis 5 0.0127532
BCL9L B-cell CLL/lymphoma 9-like 0.0126131
ARHGAP32 Rho GTPase activating protein 32 0.0126039
DPY19L1 dpy-19-like 1 (C. elegans) 0.0125776
CHSY1 chondroitin sulfate synthase 1 0.0123954
RPL36 ribosomal protein L36 0.0123155
RPL23 ribosomal protein L23 0.0122994
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0121391
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.012126
SGMS2 sphingomyelin synthase 2 0.0120937
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0120025
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0119227
TBC1D5 TBC1 domain family, member 5 0.0118612
YAP1 Yes-associated protein 1 0.0117837
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.0117118
MSN moesin 0.0116766

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.297194
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.276655
NRG1 neuregulin 1 -0.247248
FN1 fibronectin 1 -0.222867
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.181356
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.165733
CANX calnexin -0.142201
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.140503
PTMA prothymosin, alpha -0.137473
SQSTM1 sequestosome 1 -0.134381
FTH1 ferritin, heavy polypeptide 1 -0.12618
CXCL8 chemokine (C-X-C motif) ligand 8 -0.108001
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0897093
TMSB4X thymosin beta 4, X-linked -0.0875423
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0701605
HMGA2 high mobility group AT-hook 2 -0.0671792
S100A6 S100 calcium binding protein A6 -0.0653928
STC2 stanniocalcin 2 -0.060864
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0605007
HLA-B major histocompatibility complex, class I, B -0.0601584
TMSB10 thymosin beta 10 -0.0600089
PLIN2 perilipin 2 -0.0582102
NAMPT nicotinamide phosphoribosyltransferase -0.0503556
PDIA3 protein disulfide isomerase family A, member 3 -0.0498285
HILPDA hypoxia inducible lipid droplet-associated -0.0498131
RAI14 retinoic acid induced 14 -0.0486098
SOD2 superoxide dismutase 2, mitochondrial -0.0467292
ITGA1 integrin, alpha 1 -0.0461109
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0448932
LOC112694756 uncharaterized LOC112694756 -0.0448561
AEBP2 AE binding protein 2 -0.0445973
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0441865
CALR calreticulin -0.0429867
CADM1 cell adhesion molecule 1 -0.0421395
EFNA5 ephrin-A5 -0.0421149
MRPS6 mitochondrial ribosomal protein S6 -0.0417144
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0409965
RPL35A ribosomal protein L35a -0.0408673
TFPI2 tissue factor pathway inhibitor 2 -0.040818
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0407759
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0400269
LIMCH1 LIM and calponin homology domains 1 -0.0399552
PGK1 phosphoglycerate kinase 1 -0.0390422
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0386931
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0385605
TMEM165 transmembrane protein 165 -0.0380819
TPT1 tumor protein, translationally-controlled 1 -0.0377939
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0376798
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0375755
H1-0 H1.0 linker histone -0.0375127
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0374867
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0373385
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0372847
LOX lysyl oxidase -0.0371985
TAS2R14 taste receptor, type 2, member 14 -0.0371867
GOLGA4 golgin A4 -0.0357534
HDLBP high density lipoprotein binding protein -0.0352891
LRRC23 leucine rich repeat containing 23 -0.0350658
GNAS GNAS complex locus -0.0341774
PDE4D phosphodiesterase 4D, cAMP-specific -0.0341173
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.033433
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0328398
ACTG1 actin gamma 1 -0.032821
PKM pyruvate kinase, muscle -0.0327183
IFI27 interferon, alpha-inducible protein 27 -0.0321548
KDM3A lysine (K)-specific demethylase 3A -0.0314277
RAD21 RAD21 homolog (S. pombe) -0.0312665
UGDH UDP-glucose 6-dehydrogenase -0.0309791
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0308786
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0307235
TMEM263 transmembrane protein 263 -0.0304117
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0303207
PDIA4 protein disulfide isomerase family A, member 4 -0.0298502
INTS6 integrator complex subunit 6 -0.0297284
TPM4 tropomyosin 4 -0.0297075
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0296642
COPA coatomer protein complex, subunit alpha -0.0292172
KDM5B lysine (K)-specific demethylase 5B -0.0287839
CEP350 centrosomal protein 350kDa -0.0286402
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0285371
AHNAK AHNAK nucleoprotein -0.0283983
CALU calumenin -0.0282616
FAM20C family with sequence similarity 20, member C -0.0279887
ARHGAP35 Rho GTPase activating protein 35 -0.0276832
SYT1 synaptotagmin I -0.0276629
TENM4 teneurin transmembrane protein 4 -0.0274276
IRAK3 interleukin-1 receptor-associated kinase 3 -0.0270372
UBC ubiquitin C -0.0270087
SEC31A SEC31 homolog A (S. cerevisiae) -0.0266905
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0262307
CD109 CD109 molecule -0.026066
SPDYA speedy/RINGO cell cycle regulator family member A -0.0257821
AHI1 Abelson helper integration site 1 -0.0253778
ZMYND8 zinc finger, MYND-type containing 8 -0.0253025
MMP13 matrix metallopeptidase 13 -0.0252665
INSIG2 insulin induced gene 2 -0.0249211
KPNB1 karyopherin (importin) beta 1 -0.0246896
RPLP1 ribosomal protein, large, P1 -0.0244483
TNS3 tensin 3 -0.0243976
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0242866