(R)-Verapamil (hydrochloride)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (R)-Verapamil (hydrochloride) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the (R)-Verapamil (hydrochloride)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
BCL2L1 BCL2-like 1 0.133887
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.112891
RPS12 ribosomal protein S12 0.0935981
FTL ferritin, light polypeptide 0.0783759
RPS3 ribosomal protein S3 0.07721
NEBL nebulette 0.0726189
MYO1E myosin IE 0.0639523
RPS4X ribosomal protein S4, X-linked 0.0593466
RPL18 ribosomal protein L18 0.0591312
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0573006
LOC102724023 ES1 protein homolog, mitochondrial 0.0492796
CEMIP cell migration inducing protein, hyaluronan binding 0.0488423
RPL23 ribosomal protein L23 0.0484781
RPL37A ribosomal protein L37a 0.0482951
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0466561
NCEH1 neutral cholesterol ester hydrolase 1 0.0455771
RPL36 ribosomal protein L36 0.0452865
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0450461
HSPA8 heat shock 70kDa protein 8 0.0444052
EZR ezrin 0.0427567
RPS19 ribosomal protein S19 0.0412011
PRRC2C proline-rich coiled-coil 2C 0.0395396
RPS2 ribosomal protein S2 0.0393035
TOB1 transducer of ERBB2, 1 0.0380104
AKAP9 A kinase (PRKA) anchor protein 9 0.0378603
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0377409
RPS17 ribosomal protein S17 0.0376307
ACTN1 actinin, alpha 1 0.0369575
SAMD4A sterile alpha motif domain containing 4A 0.0362094
ZFP36L2 ZFP36 ring finger protein-like 2 0.0348035
RPL12 ribosomal protein L12 0.0346791
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0338807
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0333203
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0330861
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0327115
NACA nascent polypeptide-associated complex alpha subunit 0.0321043
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0317864
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0315713
WWC1 WW and C2 domain containing 1 0.0315509
RPS8 ribosomal protein S8 0.0311036
APLP2 amyloid beta (A4) precursor-like protein 2 0.0310922
SFTPA2 surfactant protein A2 0.0302521
SVIL supervillin 0.0299268
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0294411
ANKRD12 ankyrin repeat domain 12 0.029143
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0289926
MORF4L2 mortality factor 4 like 2 0.0288289
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0287704
SEPTIN9 septin 9 0.0286912
KRT18 keratin 18, type I 0.0285868
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0283387
TXNIP thioredoxin interacting protein 0.0283331
PCLO piccolo presynaptic cytomatrix protein 0.0281018
ARHGAP42 Rho GTPase activating protein 42 0.0279113
CTBP2 C-terminal binding protein 2 0.0278874
SET SET nuclear proto-oncogene 0.0278602
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0278144
SMYD3 SET and MYND domain containing 3 0.027679
NDRG1 N-myc downstream regulated 1 0.0275749
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0273997
CREBBP CREB binding protein 0.0273058
B2M beta-2-microglobulin 0.0272524
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0272395
ZSWIM6 zinc finger, SWIM-type containing 6 0.0271553
TJP1 tight junction protein 1 0.0271018
LIMA1 LIM domain and actin binding 1 0.0269444
EXT1 exostosin glycosyltransferase 1 0.0269168
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0268783
RPL5 ribosomal protein L5 0.0267079
MACF1 microtubule-actin crosslinking factor 1 0.0266949
RACK1 receptor for activated C kinase 1 0.0265875
ETV6 ets variant 6 0.0265214
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0264858
ATXN1 ataxin 1 0.0263958
RPS27 ribosomal protein S27 0.0259779
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.025885
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0258131
LIMS1 LIM and senescent cell antigen-like domains 1 0.0257576
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0257421
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.025739
OSBPL10 oxysterol binding protein-like 10 0.0256951
CMIP c-Maf inducing protein 0.0255582
GPHN gephyrin 0.0255176
TRIM2 tripartite motif containing 2 0.0253509
ADAM19 ADAM metallopeptidase domain 19 0.0253288
EGFR epidermal growth factor receptor 0.0252243
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0252
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0250483
DOCK5 dedicator of cytokinesis 5 0.0249257
TBC1D5 TBC1 domain family, member 5 0.0245535
NRP1 neuropilin 1 0.0244058
SMAD3 SMAD family member 3 0.0243749
VMP1 vacuole membrane protein 1 0.0243698
SON SON DNA binding protein 0.0242932
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0240524
NHSL1 NHS-like 1 0.0237952
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0235477
TGFA transforming growth factor, alpha 0.0232363
SOX9 SRY (sex determining region Y)-box 9 0.0231881
SKAP2 src kinase associated phosphoprotein 2 0.0231091

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.299527
KRT8 keratin 8, type II -0.103121
FTH1 ferritin, heavy polypeptide 1 -0.0918853
CCND1 cyclin D1 -0.0681266
H1-0 H1.0 linker histone -0.0661635
RPL35A ribosomal protein L35a -0.0640697
PERP PERP, TP53 apoptosis effector -0.0608926
LOC112694756 uncharaterized LOC112694756 -0.0561967
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0561834
TMEM123 transmembrane protein 123 -0.0540216
S100A6 S100 calcium binding protein A6 -0.0493094
USP3 ubiquitin specific peptidase 3 -0.0489455
IER3 immediate early response 3 -0.0481842
MAML2 mastermind-like 2 (Drosophila) -0.046793
GNAS GNAS complex locus -0.0467231
RAD21 RAD21 homolog (S. pombe) -0.0461974
TPM4 tropomyosin 4 -0.0432046
KDM3A lysine (K)-specific demethylase 3A -0.0407056
AHNAK AHNAK nucleoprotein -0.0405306
PDIA3 protein disulfide isomerase family A, member 3 -0.0394702
CTSD cathepsin D -0.0392898
ANXA2 annexin A2 -0.0389349
EPCAM epithelial cell adhesion molecule -0.0380594
RHEB Ras homolog enriched in brain -0.0374939
POTEF POTE ankyrin domain family, member F -0.0362259
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0345687
GARS1 glycyl-tRNA synthetase 1 -0.0341952
ZMYND8 zinc finger, MYND-type containing 8 -0.033465
TMSB4X thymosin beta 4, X-linked -0.0333083
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0332679
RBM39 RNA binding motif protein 39 -0.0330404
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0327512
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0326776
FAM3C family with sequence similarity 3, member C -0.03192
XPO1 exportin 1 -0.031064
NDFIP1 Nedd4 family interacting protein 1 -0.0309819
MATR3 matrin 3 -0.0303648
GOLGA4 golgin A4 -0.0294135
TMSB10 thymosin beta 10 -0.0294104
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0292937
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.028942
HMGB1 high mobility group box 1 -0.0285407
KPNB1 karyopherin (importin) beta 1 -0.0281455
SLC38A1 solute carrier family 38, member 1 -0.0277816
OGA O-GlcNAcase -0.027593
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0275272
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0273314
CCNL1 cyclin L1 -0.0272091
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0268981
TRA2A transformer 2 alpha homolog (Drosophila) -0.0264426
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0257786
RPS13 ribosomal protein S13 -0.0257049
SETD5 SET domain containing 5 -0.0256753
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0255243
OLA1 Obg-like ATPase 1 -0.0254638
TCERG1 transcription elongation regulator 1 -0.0251046
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0249534
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0249101
RSL1D1 ribosomal L1 domain containing 1 -0.0248641
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0247879
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0247469
JUP junction plakoglobin -0.0246908
RPS25 ribosomal protein S25 -0.024461
CPLX2 complexin 2 -0.0244135
PGK1 phosphoglycerate kinase 1 -0.0240699
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0238462
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0238373
ZNF207 zinc finger protein 207 -0.0237198
RPL27A ribosomal protein L27a -0.0235579
LARS1 leucyl-tRNA synthetase 1 -0.022711
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0225517
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.022473
ACTN4 actinin, alpha 4 -0.0224262
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0223821
MARCHF6 membrane associated ring-CH-type finger 6 -0.0223048
TPT1 tumor protein, translationally-controlled 1 -0.0221563
RPLP0 ribosomal protein, large, P0 -0.0221228
UGCG UDP-glucose ceramide glucosyltransferase -0.0219113
S100A2 S100 calcium binding protein A2 -0.0218972
VDAC1 voltage-dependent anion channel 1 -0.0218597
HLA-A major histocompatibility complex, class I, A -0.0217372
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0216488
CST3 cystatin C -0.0215784
RPS21 ribosomal protein S21 -0.021248
DEK DEK proto-oncogene -0.021229
ADAM17 ADAM metallopeptidase domain 17 -0.021154
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0210812
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0210159
RPS24 ribosomal protein S24 -0.0209709
PRPF38B pre-mRNA processing factor 38B -0.0209487
DLG1 discs, large homolog 1 (Drosophila) -0.020845
ANKRD28 ankyrin repeat domain 28 -0.0207833
RAB1A RAB1A, member RAS oncogene family -0.0205308
HMGA1 high mobility group AT-hook 1 -0.0204769
RPL34 ribosomal protein L34 -0.0194881
COPB1 coatomer protein complex, subunit beta 1 -0.0194693
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0194463
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0194339
ARHGAP12 Rho GTPase activating protein 12 -0.0192432
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0190669