(R)-Verapamil (hydrochloride)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (R)-Verapamil (hydrochloride) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the (R)-Verapamil (hydrochloride)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ANXA1 annexin A1 0.0580174
HILPDA hypoxia inducible lipid droplet-associated 0.0544172
RPS4X ribosomal protein S4, X-linked 0.047373
NDRG1 N-myc downstream regulated 1 0.042849
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0347268
TSC22D2 TSC22 domain family, member 2 0.0345778
HSPA8 heat shock 70kDa protein 8 0.0320445
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.029214
EZR ezrin 0.0281426
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0266674
WAC WW domain containing adaptor with coiled-coil 0.0248724
RNF145 ring finger protein 145 0.0247783
ZNF292 zinc finger protein 292 0.0239257
NUP58 nucleoporin 58 0.0236218
PCM1 pericentriolar material 1 0.023251
AREG amphiregulin 0.0229782
SNX9 sorting nexin 9 0.0222493
DDIT4 DNA-damage-inducible transcript 4 0.0218244
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0209773
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0200282
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0195451
RPS12 ribosomal protein S12 0.0193089
FBXO11 F-box protein 11 0.0191565
UBA6 ubiquitin-like modifier activating enzyme 6 0.0191478
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0186649
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0185322
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0183762
NAV2 neuron navigator 2 0.0183606
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0180763
SPATS2L spermatogenesis associated, serine-rich 2-like 0.017837
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0177242
MT2A metallothionein 2A 0.0175975
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0173055
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0171944
KDM6A lysine (K)-specific demethylase 6A 0.0171739
USP3 ubiquitin specific peptidase 3 0.017165
WSB1 WD repeat and SOCS box containing 1 0.0169451
COPA coatomer protein complex, subunit alpha 0.0169434
PNN pinin, desmosome associated protein 0.0167572
ARRDC3 arrestin domain containing 3 0.0167126
ERRFI1 ERBB receptor feedback inhibitor 1 0.0162078
TXNIP thioredoxin interacting protein 0.0161438
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0160884
PCBP2 poly(rC) binding protein 2 0.0160344
CPOX coproporphyrinogen oxidase 0.0159833
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0157383
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.015531
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0155245
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0154491
RNASEH2A ribonuclease H2, subunit A 0.0153396
JUN jun proto-oncogene 0.0153252
ANXA5 annexin A5 0.0152916
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0151938
NAMPT nicotinamide phosphoribosyltransferase 0.0151246
ACTN1 actinin, alpha 1 0.0150254
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.014935
FXR1 fragile X mental retardation, autosomal homolog 1 0.0149185
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0148904
KMT2C lysine (K)-specific methyltransferase 2C 0.0145006
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0144773
IL18 interleukin 18 0.0144113
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0142106
RSRC2 arginine/serine-rich coiled-coil 2 0.013926
SEC63 SEC63 homolog (S. cerevisiae) 0.0138642
FHL2 four and a half LIM domains 2 0.0137539
TRA2A transformer 2 alpha homolog (Drosophila) 0.0135436
GPBP1 GC-rich promoter binding protein 1 0.013466
RPS3 ribosomal protein S3 0.0134164
SPRED2 sprouty-related, EVH1 domain containing 2 0.0133417
EIF4A1 eukaryotic translation initiation factor 4A1 0.0133079
LRRC1 leucine rich repeat containing 1 0.0132632
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.0132502
ELL2 elongation factor, RNA polymerase II, 2 0.0132238
FLNA filamin A, alpha 0.013016
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0129099
MXI1 MAX interactor 1, dimerization protein 0.0128211
SYAP1 synapse associated protein 1 0.012804
CDC73 cell division cycle 73 0.0125975
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0125712
TES testin LIM domain protein 0.0125411
USP9X ubiquitin specific peptidase 9, X-linked 0.0125036
EFNB2 ephrin-B2 0.0125027
PARD3 par-3 family cell polarity regulator 0.0124218
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0123862
ADARB1 adenosine deaminase, RNA-specific, B1 0.0123285
FLNB filamin B, beta 0.0122496
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0122334
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0122222
ATXN1 ataxin 1 0.0121548
FBXO33 F-box protein 33 0.0121435
CDC27 cell division cycle 27 0.0120888
DPY19L1 dpy-19-like 1 (C. elegans) 0.0120608
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0120547
FAM107B family with sequence similarity 107, member B 0.0120372
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0120141
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0119089
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0117826
GPC6 glypican 6 0.0116907
SLTM SAFB-like, transcription modulator 0.0116037
MTPN myotrophin 0.0115627

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.29348
FRAS1 Fraser extracellular matrix complex subunit 1 -0.101407
LMO7 LIM domain 7 -0.0986142
FERMT1 fermitin family member 1 -0.0852256
PTMA prothymosin, alpha -0.0803853
ACTG1 actin gamma 1 -0.0750918
HDAC2 histone deacetylase 2 -0.0727714
VCL vinculin -0.0722189
RPL35A ribosomal protein L35a -0.0685473
ANXA2 annexin A2 -0.0676401
RAD51B RAD51 paralog B -0.0675502
ITPKC inositol-trisphosphate 3-kinase C -0.0661231
MTAP methylthioadenosine phosphorylase -0.0642429
LAMB3 laminin, beta 3 -0.0641046
RPS6 ribosomal protein S6 -0.0624074
RPS24 ribosomal protein S24 -0.0620794
EGR1 early growth response 1 -0.0612401
HMGA2 high mobility group AT-hook 2 -0.0611117
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0602951
RAB10 RAB10, member RAS oncogene family -0.0585523
SERINC5 serine incorporator 5 -0.0558989
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0555753
OXR1 oxidation resistance 1 -0.0546044
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0542312
FLOT1 flotillin 1 -0.0499848
RPLP0 ribosomal protein, large, P0 -0.0497343
RPL4 ribosomal protein L4 -0.0488971
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.048324
CD36 CD36 molecule (thrombospondin receptor) -0.0479875
RBM25 RNA binding motif protein 25 -0.0464908
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0464154
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0443041
CUX1 cut-like homeobox 1 -0.0435781
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0435243
CANX calnexin -0.0434495
RUNX2 runt-related transcription factor 2 -0.0432613
LOC102724023 ES1 protein homolog, mitochondrial -0.0419602
PERP PERP, TP53 apoptosis effector -0.0419093
FHIT fragile histidine triad -0.0415863
TMSB10 thymosin beta 10 -0.0395351
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0391285
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor -0.0383
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0379867
ACTN4 actinin, alpha 4 -0.0379571
RPL11 ribosomal protein L11 -0.0373582
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0371851
LOC112694756 uncharaterized LOC112694756 -0.0371669
DSPP dentin sialophosphoprotein -0.0362589
RPLP1 ribosomal protein, large, P1 -0.036066
LAMA4 laminin, alpha 4 -0.0360236
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0353894
PATJ PATJ crumbs cell polarity complex component -0.0351274
TXNRD1 thioredoxin reductase 1 -0.0350054
KLF5 Kruppel-like factor 5 (intestinal) -0.0348748
S100A6 S100 calcium binding protein A6 -0.0346987
SRRM2 serine/arginine repetitive matrix 2 -0.0346863
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.034222
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0339755
GOLGA4 golgin A4 -0.0336903
IARS1 isoleucyl-tRNA synthetase 1 -0.0332933
KLK10 kallikrein-related peptidase 10 -0.0332579
RSL1D1 ribosomal L1 domain containing 1 -0.0329688
SGPP2 sphingosine-1-phosphate phosphatase 2 -0.0328913
CD9 CD9 molecule -0.0326074
RPS28 ribosomal protein S28 -0.0318982
TOP1 topoisomerase (DNA) I -0.0315269
RPL12 ribosomal protein L12 -0.0311652
MAP4 microtubule-associated protein 4 -0.0305555
AHNAK AHNAK nucleoprotein -0.0302917
AOPEP aminopeptidase O (putative) -0.0301878
ZBTB7C zinc finger and BTB domain containing 7C -0.0301621
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0297236
FTH1 ferritin, heavy polypeptide 1 -0.0295976
NF1 neurofibromin 1 -0.0289003
TNS3 tensin 3 -0.0288014
KLF3 Kruppel-like factor 3 (basic) -0.0287449
RPL34 ribosomal protein L34 -0.0286795
SMYD3 SET and MYND domain containing 3 -0.0286245
TPM4 tropomyosin 4 -0.0283484
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.028336
GMDS GDP-mannose 4,6-dehydratase -0.0280163
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.02782
TAS2R14 taste receptor, type 2, member 14 -0.0278157
SCFD1 sec1 family domain containing 1 -0.0273171
UBE3C ubiquitin protein ligase E3C -0.027274
RPS25 ribosomal protein S25 -0.0272021
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0270366
NCEH1 neutral cholesterol ester hydrolase 1 -0.0269347
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0266448
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0266389
RPLP2 ribosomal protein, large, P2 -0.0264597
AK1 adenylate kinase 1 -0.0262589
PRRC2B proline-rich coiled-coil 2B -0.025836
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0255733
ATP5F1B ATP synthase F1 subunit beta -0.0254341
CCND1 cyclin D1 -0.0251908
DENND1A DENN/MADD domain containing 1A -0.0251038
TUT4 terminal uridylyl transferase 4 -0.0250743
GSK3B glycogen synthase kinase 3 beta -0.0250331
NEMF nuclear export mediator factor -0.0250296