| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | (S)-Crizotinib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the (S)-Crizotinib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.152266 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.135877 |
| NLGN1 | neuroligin 1 | 0.105131 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0935946 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0831791 |
| VIM | vimentin | 0.0800669 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0730891 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0710532 |
| ANXA1 | annexin A1 | 0.070057 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0668446 |
| DST | dystonin | 0.0626013 |
| PCDH7 | protocadherin 7 | 0.0604721 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0602827 |
| YAP1 | Yes-associated protein 1 | 0.0599813 |
| MMP12 | matrix metallopeptidase 12 | 0.0564267 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0542321 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0541776 |
| HMGA2 | high mobility group AT-hook 2 | 0.0532717 |
| LDHA | lactate dehydrogenase A | 0.0524658 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.05215 |
| ASPH | aspartate beta-hydroxylase | 0.0518703 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0515447 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0510714 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0498054 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.048362 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0476636 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0475365 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0470874 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0457798 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0454312 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0451562 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0431931 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0421879 |
| EHBP1 | EH domain binding protein 1 | 0.0417648 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0412167 |
| RRM2 | ribonucleotide reductase M2 | 0.0393232 |
| TPI1 | triosephosphate isomerase 1 | 0.0390048 |
| ENO1 | enolase 1, (alpha) | 0.0377356 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0376426 |
| NHSL1 | NHS-like 1 | 0.0375982 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0354771 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0350328 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0334055 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0332397 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0331525 |
| NEBL | nebulette | 0.0329954 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0324058 |
| PCBP2 | poly(rC) binding protein 2 | 0.0321626 |
| PTMA | prothymosin, alpha | 0.0321176 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0320983 |
| SMYD3 | SET and MYND domain containing 3 | 0.0319926 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0308767 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0300765 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.0300624 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0298361 |
| IPO7 | importin 7 | 0.0292633 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0292345 |
| EXOC4 | exocyst complex component 4 | 0.0282694 |
| MED13L | mediator complex subunit 13-like | 0.0279976 |
| CLDN1 | claudin 1 | 0.0275623 |
| PGK1 | phosphoglycerate kinase 1 | 0.0274958 |
| PCDH9 | protocadherin 9 | 0.0274442 |
| AHNAK | AHNAK nucleoprotein | 0.0272362 |
| XPO1 | exportin 1 | 0.0271708 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0269974 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0267525 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0263952 |
| TENM3 | teneurin transmembrane protein 3 | 0.0263577 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0259628 |
| CANX | calnexin | 0.0257608 |
| MTAP | methylthioadenosine phosphorylase | 0.0257406 |
| TXNRD1 | thioredoxin reductase 1 | 0.0255541 |
| ADIPOR2 | adiponectin receptor 2 | 0.0253221 |
| WWOX | WW domain containing oxidoreductase | 0.0251745 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0251687 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0251458 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | 0.0249591 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0249129 |
| CALR | calreticulin | 0.0248665 |
| CENPF | centromere protein F, 350/400kDa | 0.0247267 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0247245 |
| CLTC | clathrin, heavy chain (Hc) | 0.0243806 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0238023 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0237019 |
| ZNF292 | zinc finger protein 292 | 0.023627 |
| EPHA6 | EPH receptor A6 | 0.0235225 |
| RASAL2 | RAS protein activator like 2 | 0.0234532 |
| TPM3 | tropomyosin 3 | 0.0233563 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.023284 |
| MKI67 | marker of proliferation Ki-67 | 0.0229614 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0229325 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0227957 |
| PTK2 | protein tyrosine kinase 2 | 0.022789 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0226885 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0226479 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.022638 |
| LMO7 | LIM domain 7 | 0.0226295 |
| DSPP | dentin sialophosphoprotein | 0.0224518 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0224105 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0222532 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AREG | amphiregulin | -0.1087 |
| TMSB10 | thymosin beta 10 | -0.0329618 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0237818 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0212443 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0195752 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0174479 |
| PFN1 | profilin 1 | -0.0160489 |
| RPL35A | ribosomal protein L35a | -0.0146957 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0144464 |
| CCNL1 | cyclin L1 | -0.0131522 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0123381 |
| EGR1 | early growth response 1 | -0.0120931 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0113639 |
| DHX29 | DEAH (Asp-Glu-Ala-His) box polypeptide 29 | -0.0107781 |
| RPS2 | ribosomal protein S2 | -0.0105881 |
| FTL | ferritin, light polypeptide | -0.0102345 |
| RPL9 | ribosomal protein L9 | -0.0100859 |
| WASF2 | WAS protein family, member 2 | -0.00992352 |
| RSPRY1 | ring finger and SPRY domain containing 1 | -0.00990129 |
| RBMS2 | RNA binding motif, single stranded interacting protein 2 | -0.00978099 |
| RPL11 | ribosomal protein L11 | -0.00954366 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.00946864 |
| RIMKLB | ribosomal modification protein rimK-like family member B | -0.00902303 |
| YBX1 | Y box binding protein 1 | -0.0089512 |
| ANKUB1 | ankyrin repeat and ubiquitin domain containing 1 | -0.00877773 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.00875968 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0086949 |
| RPL37A | ribosomal protein L37a | -0.00846973 |
| PTMS | parathymosin | -0.0080978 |
| RPS29 | ribosomal protein S29 | -0.008069 |
| ATN1 | atrophin 1 | -0.00795275 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.00777685 |
| PCM1 | pericentriolar material 1 | -0.00751889 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.00747489 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.00742591 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.00732463 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.00731389 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | -0.00721874 |
| PI4KB | phosphatidylinositol 4-kinase, catalytic, beta | -0.00720044 |
| RPL34 | ribosomal protein L34 | -0.00713591 |
| NCOR2 | nuclear receptor corepressor 2 | -0.00706547 |
| CALD1 | caldesmon 1 | -0.00706263 |
| WWC2 | WW and C2 domain containing 2 | -0.0070165 |
| MBD6 | methyl-CpG binding domain protein 6 | -0.00674612 |
| ARL13B | ADP-ribosylation factor-like 13B | -0.00666545 |
| SNRPN | small nuclear ribonucleoprotein polypeptide N | -0.00664635 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.00660731 |
| TIMM23B | translocase of inner mitochondrial membrane 23 homolog B (yeast) | -0.00659583 |
| BTBD10 | BTB (POZ) domain containing 10 | -0.00659353 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.0064376 |
| RPL28 | ribosomal protein L28 | -0.00641854 |
| CSAD | cysteine sulfinic acid decarboxylase | -0.00630977 |
| RPS16 | ribosomal protein S16 | -0.00624727 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -0.00618652 |
| TOB2 | transducer of ERBB2, 2 | -0.00617446 |
| SLC38A9 | solute carrier family 38, member 9 | -0.00615459 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.00609016 |
| ZNF670 | zinc finger protein 670 | -0.00599739 |
| CCDC171 | coiled-coil domain containing 171 | -0.00598078 |
| SDHA | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) | -0.00593748 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.00593346 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | -0.00593012 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.00583118 |
| ACYP2 | acylphosphatase 2, muscle type | -0.00581332 |
| RPLP2 | ribosomal protein, large, P2 | -0.00579528 |
| MEAF6 | MYST/Esa1-associated factor 6 | -0.00577939 |
| PPP3CB | protein phosphatase 3, catalytic subunit, beta isozyme | -0.00577331 |
| AFTPH | aftiphilin | -0.00576489 |
| FNBP4 | formin binding protein 4 | -0.00573749 |
| PTEN | phosphatase and tensin homolog | -0.00573421 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.00569862 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.00557433 |
| SCARB1 | scavenger receptor class B, member 1 | -0.00549733 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.00544809 |
| ALS2 | amyotrophic lateral sclerosis 2 (juvenile) | -0.00544328 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.00537212 |
| FBXO9 | F-box protein 9 | -0.00535885 |
| MRPS21 | mitochondrial ribosomal protein S21 | -0.00531899 |
| RPS19 | ribosomal protein S19 | -0.00524895 |
| LENG8 | leukocyte receptor cluster (LRC) member 8 | -0.00524721 |
| KMT2D | lysine (K)-specific methyltransferase 2D | -0.00523868 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.00519085 |
| DUSP6 | dual specificity phosphatase 6 | -0.00518398 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.00518101 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.00509274 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.00509161 |
| UBA1 | ubiquitin-like modifier activating enzyme 1 | -0.00506697 |
| COX8A | cytochrome c oxidase subunit VIIIA (ubiquitous) | -0.00505857 |
| ZNF26 | zinc finger protein 26 | -0.00505131 |
| WDR20 | WD repeat domain 20 | -0.00504629 |
| SGMS2 | sphingomyelin synthase 2 | -0.004987 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.00497563 |
| VAMP2 | vesicle-associated membrane protein 2 (synaptobrevin 2) | -0.00495628 |
| PFDN5 | prefoldin subunit 5 | -0.00493484 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.00491408 |
| WIPF2 | WAS/WASL interacting protein family, member 2 | -0.00491399 |
| DHFR | dihydrofolate reductase | -0.00490306 |
| TGOLN2 | trans-golgi network protein 2 | -0.00486578 |
| TOMM7 | translocase of outer mitochondrial membrane 7 homolog (yeast) | -0.0048528 |
| CCDC126 | coiled-coil domain containing 126 | -0.00484855 |
