(S)-Crizotinib_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (S)-Crizotinib perturbation in COLO 205 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the (S)-Crizotinib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.179563
RUNX1 runt-related transcription factor 1 0.0773143
MACC1 metastasis associated in colon cancer 1 0.0697963
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0676937
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0615228
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0541643
FNDC3A fibronectin type III domain containing 3A 0.0509599
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0499783
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0483953
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.044656
PCCA propionyl CoA carboxylase, alpha polypeptide 0.042857
PRELID2 PRELI domain containing 2 0.0423593
RNF43 ring finger protein 43 0.0416025
MYO1E myosin IE 0.0415607
STK24 serine/threonine kinase 24 0.0415337
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0412001
VCL vinculin 0.0410563
ZMYM2 zinc finger, MYM-type 2 0.039578
SREBF2 sterol regulatory element binding transcription factor 2 0.0386435
RNF149 ring finger protein 149 0.0384177
AOPEP aminopeptidase O (putative) 0.038064
PTEN phosphatase and tensin homolog 0.0378185
NRIP1 nuclear receptor interacting protein 1 0.0377688
GOLGA4 golgin A4 0.0374686
PTBP3 polypyrimidine tract binding protein 3 0.036528
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0361867
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0361802
USP3 ubiquitin specific peptidase 3 0.0352668
COG6 component of oligomeric golgi complex 6 0.0350873
FNDC3B fibronectin type III domain containing 3B 0.0346051
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0343368
DSPP dentin sialophosphoprotein 0.0340916
EHF ets homologous factor 0.0328139
SBF2 SET binding factor 2 0.0321842
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0318848
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0315614
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0312244
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0304228
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.029781
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0296124
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0293494
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0288711
INSIG1 insulin induced gene 1 0.0286475
YAP1 Yes-associated protein 1 0.0285539
BIRC6 baculoviral IAP repeat containing 6 0.028542
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0285306
TM9SF2 transmembrane 9 superfamily member 2 0.0281844
KDM6A lysine (K)-specific demethylase 6A 0.0279606
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0278884
BTBD9 BTB (POZ) domain containing 9 0.0277856
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0276166
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0275788
ERRFI1 ERBB receptor feedback inhibitor 1 0.0271189
SUCO SUN domain containing ossification factor 0.0268682
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0266028
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0264699
UBAC2 UBA domain containing 2 0.0263871
PDIA3 protein disulfide isomerase family A, member 3 0.0263338
TNRC6A trinucleotide repeat containing 6A 0.0260573
MBNL2 muscleblind-like splicing regulator 2 0.0259576
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0259455
NCOA3 nuclear receptor coactivator 3 0.0259275
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0258218
ARRDC3 arrestin domain containing 3 0.0257032
ZDHHC20 zinc finger, DHHC-type containing 20 0.0255539
MYH9 myosin, heavy chain 9, non-muscle 0.0251982
BHLHE40 basic helix-loop-helix family, member e40 0.0250301
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0249302
HELZ helicase with zinc finger 0.0247004
MCTP2 multiple C2 domains, transmembrane 2 0.0244534
NEBL nebulette 0.023999
KMT2C lysine (K)-specific methyltransferase 2C 0.0239896
SEC24D SEC24 family member D 0.0239857
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0238536
ETNK1 ethanolamine kinase 1 0.0238445
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.023737
NCKAP5 NCK-associated protein 5 0.0233813
MSMO1 methylsterol monooxygenase 1 0.0233382
MON2 MON2 homolog (S. cerevisiae) 0.0230131
CLTC clathrin, heavy chain (Hc) 0.0228347
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0228107
OGA O-GlcNAcase 0.022785
RARS1 arginyl-tRNA synthetase 1 0.0224835
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.022445
LRRC1 leucine rich repeat containing 1 0.0223889
ACSL1 acyl-CoA synthetase long-chain family member 1 0.0222497
FDPS farnesyl diphosphate synthase 0.0221814
GSK3B glycogen synthase kinase 3 beta 0.0221304
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.0218532
FNIP1 folliculin interacting protein 1 0.0217785
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0214292
SKIC3 SKI3 subunit of superkiller complex 0.0207695
RBM39 RNA binding motif protein 39 0.0206924
TBPL1 TBP-like 1 0.0205304
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0204896
ATP11B ATPase, class VI, type 11B 0.0204092
MEIS2 Meis homeobox 2 0.0203705
NCOR1 nuclear receptor corepressor 1 0.0201089
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0199919
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0198868

decreased expression

Symbol Name Standardized Value
EPSTI1 epithelial stromal interaction 1 (breast) -0.210327
TPT1 tumor protein, translationally-controlled 1 -0.17003
B2M beta-2-microglobulin -0.165354
RNF213 ring finger protein 213 -0.128291
PTMA prothymosin, alpha -0.1119
LYZ lysozyme -0.109597
LCN2 lipocalin 2 -0.0984519
EGR1 early growth response 1 -0.0969919
RIGI RNA sensor RIG-I -0.0928821
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0927809
MX1 MX dynamin-like GTPase 1 -0.0870192
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0859945
HLA-B major histocompatibility complex, class I, B -0.0849782
SP100 SP100 nuclear antigen -0.0845588
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0807158
IFI6 interferon, alpha-inducible protein 6 -0.0754516
PERP PERP, TP53 apoptosis effector -0.0710896
LMO7 LIM domain 7 -0.0661764
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0623535
MX2 MX dynamin-like GTPase 2 -0.0620978
EIF1 eukaryotic translation initiation factor 1 -0.0593567
ZMYND8 zinc finger, MYND-type containing 8 -0.0589599
XAF1 XIAP associated factor 1 -0.0550265
RPS6 ribosomal protein S6 -0.0548236
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0545136
RAB7A RAB7A, member RAS oncogene family -0.0534796
RPL35A ribosomal protein L35a -0.0527571
EXT1 exostosin glycosyltransferase 1 -0.0521117
IGFBP3 insulin-like growth factor binding protein 3 -0.0509532
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0497037
TMC5 transmembrane channel-like 5 -0.0477092
SQSTM1 sequestosome 1 -0.0477046
EPHB2 EPH receptor B2 -0.0476765
PMP22 peripheral myelin protein 22 -0.0465886
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0462268
IFI27 interferon, alpha-inducible protein 27 -0.0454114
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0452888
ACTG1 actin gamma 1 -0.0444948
INTS6 integrator complex subunit 6 -0.0438807
SPATA13 spermatogenesis associated 13 -0.043079
IFIH1 interferon induced with helicase C domain 1 -0.0427758
C6ORF132 chromosome 6 open reading frame 132 -0.0427566
FTL ferritin, light polypeptide -0.0425288
PKM pyruvate kinase, muscle -0.0421114
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0417503
TMSB10 thymosin beta 10 -0.0409407
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0406132
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0404242
RPLP1 ribosomal protein, large, P1 -0.0404209
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0400373
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0394049
RABGAP1L RAB GTPase activating protein 1-like -0.0392799
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0378047
RPL34 ribosomal protein L34 -0.0377581
ANXA2 annexin A2 -0.0373951
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0369803
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0369534
MAP7 microtubule-associated protein 7 -0.0366254
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0364771
MUC20 mucin 20, cell surface associated -0.0364748
SLC38A1 solute carrier family 38, member 1 -0.0358879
MAML2 mastermind-like 2 (Drosophila) -0.0347005
GCC2 GRIP and coiled-coil domain containing 2 -0.0345554
HLA-E major histocompatibility complex, class I, E -0.0344806
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.034101
PARP9 poly (ADP-ribose) polymerase family, member 9 -0.0339084
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0338664
LAP3 leucine aminopeptidase 3 -0.0334564
UBC ubiquitin C -0.0331969
TSC22D1 TSC22 domain family, member 1 -0.0329208
PLSCR1 phospholipid scramblase 1 -0.0325801
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0324916
MPHOSPH8 M-phase phosphoprotein 8 -0.0324497
IRF1 interferon regulatory factor 1 -0.0322955
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0318892
MT2A metallothionein 2A -0.0317119
RPL7L1 ribosomal protein L7-like 1 -0.0317047
NPSR1 neuropeptide S receptor 1 -0.0316958
SDC4 syndecan 4 -0.0316437
RPL31 ribosomal protein L31 -0.0314844
RPL26 ribosomal protein L26 -0.0309738
S100A6 S100 calcium binding protein A6 -0.0308145
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0302814
RPS8 ribosomal protein S8 -0.0301708
PLSCR2 phospholipid scramblase 2 -0.0300703
TXNIP thioredoxin interacting protein -0.0299035
GMDS GDP-mannose 4,6-dehydratase -0.0296967
POU2F2 POU class 2 homeobox 2 -0.0295787
OASL 2'-5'-oligoadenylate synthetase-like -0.029562
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0292127
MCL1 myeloid cell leukemia 1 -0.0290979
RPS19 ribosomal protein S19 -0.0290393
LMNA lamin A/C -0.0289696
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0289229
RPS24 ribosomal protein S24 -0.0286948
CSTB cystatin B (stefin B) -0.0280671
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0276786
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.027624
RPL23 ribosomal protein L23 -0.0275465
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0274869