(S)-Crizotinib_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (S)-Crizotinib perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the (S)-Crizotinib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.256837
VEGFA vascular endothelial growth factor A 0.130227
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0806401
COL6A3 collagen, type VI, alpha 3 0.0800828
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0775254
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0716134
CDH13 cadherin 13 0.065206
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.064804
FNDC3B fibronectin type III domain containing 3B 0.0456402
NAV2 neuron navigator 2 0.0406196
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0396661
NDRG1 N-myc downstream regulated 1 0.0395213
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0394492
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.037595
ASPH aspartate beta-hydroxylase 0.0375341
SQLE squalene epoxidase 0.0351537
RBMS3 RNA binding motif, single stranded interacting protein 3 0.033373
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0323045
HDAC9 histone deacetylase 9 0.0306493
GOLGB1 golgin B1 0.0301217
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0296765
LDHA lactate dehydrogenase A 0.0294817
MSN moesin 0.0277371
HLA-A major histocompatibility complex, class I, A 0.0273931
MBNL1 muscleblind-like splicing regulator 1 0.0270656
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0261959
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0259352
EGFR epidermal growth factor receptor 0.0259198
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0254094
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0252204
RUNX1 runt-related transcription factor 1 0.0238286
ZBTB20 zinc finger and BTB domain containing 20 0.0237749
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0236976
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0235396
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0219985
NOTCH2 notch 2 0.0216962
PRELID2 PRELI domain containing 2 0.0216805
TIMP3 TIMP metallopeptidase inhibitor 3 0.0215711
CADM1 cell adhesion molecule 1 0.0211145
FNIP1 folliculin interacting protein 1 0.0207654
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0205582
TMF1 TATA element modulatory factor 1 0.0204672
VEPH1 ventricular zone expressed PH domain-containing 1 0.0195517
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0189706
INSIG1 insulin induced gene 1 0.0189568
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0188558
DST dystonin 0.018539
ELOVL5 ELOVL fatty acid elongase 5 0.0184231
MACF1 microtubule-actin crosslinking factor 1 0.0183784
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0176767
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0174445
SMYD3 SET and MYND domain containing 3 0.0172934
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0169129
DOCK5 dedicator of cytokinesis 5 0.0165623
LRRC49 leucine rich repeat containing 49 0.016512
NFE2L1 nuclear factor, erythroid 2-like 1 0.0165104
KDM4C lysine (K)-specific demethylase 4C 0.0164787
ARF4 ADP-ribosylation factor 4 0.0164419
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0163409
FBN1 fibrillin 1 0.0162642
PDIA6 protein disulfide isomerase family A, member 6 0.0155599
PCBP2 poly(rC) binding protein 2 0.0155388
ENO2 enolase 2 (gamma, neuronal) 0.0155018
PGM3 phosphoglucomutase 3 0.0153853
WARS1 tryptophanyl-tRNA synthetase 1 0.0153549
ABI3BP ABI family, member 3 (NESH) binding protein 0.0150644
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.014984
IARS1 isoleucyl-tRNA synthetase 1 0.0149379
HYOU1 hypoxia up-regulated 1 0.0149301
SREBF2 sterol regulatory element binding transcription factor 2 0.0147786
BBX bobby sox homolog (Drosophila) 0.0147746
SQSTM1 sequestosome 1 0.0146523
CSNK1A1 casein kinase 1, alpha 1 0.0146276
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0143819
DPYD dihydropyrimidine dehydrogenase 0.014361
WDPCP WD repeat containing planar cell polarity effector 0.0141068
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0139167
EVI5 ecotropic viral integration site 5 0.0138776
HM13 histocompatibility (minor) 13 0.0134919
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0133378
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0133139
MSMO1 methylsterol monooxygenase 1 0.0132629
VMP1 vacuole membrane protein 1 0.0130837
JARID2 jumonji, AT rich interactive domain 2 0.0130731
GSK3B glycogen synthase kinase 3 beta 0.0129933
CMIP c-Maf inducing protein 0.0129165
CNTN5 contactin 5 0.0128684
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.012773
ENO1 enolase 1, (alpha) 0.0127661
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.0127328
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0126889
PTEN phosphatase and tensin homolog 0.0126511
MYH9 myosin, heavy chain 9, non-muscle 0.0125204
SETX senataxin 0.0125102
FER fer (fps/fes related) tyrosine kinase 0.0122528
ATXN1 ataxin 1 0.0122329
SKAP2 src kinase associated phosphoprotein 2 0.0121556
GOLGA4 golgin A4 0.0120994
COL4A1 collagen, type IV, alpha 1 0.0120961
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.012048

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.210445
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.189262
COL1A1 collagen, type I, alpha 1 -0.164715
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0731489
MT2A metallothionein 2A -0.0665114
TMSB10 thymosin beta 10 -0.0631825
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0581509
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0464585
IER3 immediate early response 3 -0.0463231
VIM vimentin -0.0409215
PTMA prothymosin, alpha -0.0403475
TM4SF1 transmembrane 4 L six family member 1 -0.0397355
CANX calnexin -0.037977
ACTG1 actin gamma 1 -0.0360573
COL1A2 collagen, type I, alpha 2 -0.0358913
MT1X metallothionein 1X -0.0344381
RPL35A ribosomal protein L35a -0.0318164
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0317991
ATP13A3 ATPase type 13A3 -0.0309579
STC1 stanniocalcin 1 -0.0296656
COL3A1 collagen, type III, alpha 1 -0.0287872
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0273402
ANXA2 annexin A2 -0.026672
CAVIN1 caveolae associated protein 1 -0.0265562
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0261025
POSTN periostin, osteoblast specific factor -0.0260501
LMNA lamin A/C -0.0251815
ICAM1 intercellular adhesion molecule 1 -0.0244781
RPS8 ribosomal protein S8 -0.0240562
SRGN serglycin -0.0239648
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0238157
RAD21 RAD21 homolog (S. pombe) -0.0234253
ZNF292 zinc finger protein 292 -0.0233244
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0231735
TPT1 tumor protein, translationally-controlled 1 -0.0230419
WSB1 WD repeat and SOCS box containing 1 -0.0226234
PTK2 protein tyrosine kinase 2 -0.0224875
TMSB4X thymosin beta 4, X-linked -0.0217156
MARCHF6 membrane associated ring-CH-type finger 6 -0.0208271
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.020431
CALR calreticulin -0.0202764
RASA2 RAS p21 protein activator 2 -0.0200415
LOC112694756 uncharaterized LOC112694756 -0.0197118
KMT2E lysine (K)-specific methyltransferase 2E -0.0194991
RPL26 ribosomal protein L26 -0.019488
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0193879
USP3 ubiquitin specific peptidase 3 -0.0190683
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0190508
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0187097
RRBP1 ribosome binding protein 1 -0.018693
RLF rearranged L-myc fusion -0.0181109
HLA-B major histocompatibility complex, class I, B -0.0178997
RPL8 ribosomal protein L8 -0.0178934
RPLP1 ribosomal protein, large, P1 -0.0178303
NPEPPS aminopeptidase puromycin sensitive -0.0176467
RPL30 ribosomal protein L30 -0.0172637
OGA O-GlcNAcase -0.0172015
RPL34 ribosomal protein L34 -0.0169994
GNAS GNAS complex locus -0.0167114
NAP1L1 nucleosome assembly protein 1-like 1 -0.0165187
HIP1 huntingtin interacting protein 1 -0.0163646
TFG TRK-fused gene -0.0163517
PXDN peroxidasin -0.016277
TPM4 tropomyosin 4 -0.0161353
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0160559
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0160454
NAP1L4 nucleosome assembly protein 1-like 4 -0.0159081
RPS24 ribosomal protein S24 -0.0158448
SEPTIN7 septin 7 -0.0157817
TRIO trio Rho guanine nucleotide exchange factor -0.0157781
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0157526
COL6A2 collagen, type VI, alpha 2 -0.015512
RPL19 ribosomal protein L19 -0.0153016
KDM3A lysine (K)-specific demethylase 3A -0.015289
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0152169
RPL32 ribosomal protein L32 -0.0151248
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0150844
ANKRD10 ankyrin repeat domain 10 -0.0150787
SPAG9 sperm associated antigen 9 -0.0150316
RPL5 ribosomal protein L5 -0.0150248
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0149002
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0148768
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0148297
RPS3 ribosomal protein S3 -0.0147199
EXT1 exostosin glycosyltransferase 1 -0.0146723
FSTL1 follistatin-like 1 -0.0146452
WASF2 WAS protein family, member 2 -0.0145846
HDLBP high density lipoprotein binding protein -0.014497
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0144025
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0142781
SMAD3 SMAD family member 3 -0.0142443
CALU calumenin -0.0142321
GOLT1B golgi transport 1B -0.0138709
RPL28 ribosomal protein L28 -0.0138303
HLA-E major histocompatibility complex, class I, E -0.0137933
ACTN4 actinin, alpha 4 -0.0137418
SDC4 syndecan 4 -0.0135968
RAB1A RAB1A, member RAS oncogene family -0.0135377
MYO9B myosin IXB -0.0134558
RBM39 RNA binding motif protein 39 -0.0134083