(S)-Crizotinib_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (S)-Crizotinib perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the (S)-Crizotinib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.10878
IGF2 insulin-like growth factor 2 0.10006
AKAP12 A kinase (PRKA) anchor protein 12 0.087366
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0810677
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0800139
VCL vinculin 0.0624322
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0565126
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0544918
SPTBN1 spectrin, beta, non-erythrocytic 1 0.052801
PLIN2 perilipin 2 0.0520526
TF transferrin 0.0497553
DSPP dentin sialophosphoprotein 0.0487467
DST dystonin 0.0472203
SAMD4A sterile alpha motif domain containing 4A 0.0434354
VEGFA vascular endothelial growth factor A 0.0409267
ITGAV integrin, alpha V 0.0383076
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0378657
ASPH aspartate beta-hydroxylase 0.0356422
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0339756
ATXN1 ataxin 1 0.0326359
LRMDA leucine rich melanocyte differentiation associated 0.0324341
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0300001
GPC6 glypican 6 0.0299812
GMDS GDP-mannose 4,6-dehydratase 0.0296483
LCOR ligand dependent nuclear receptor corepressor 0.0287716
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.028067
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0280576
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0278867
APLP2 amyloid beta (A4) precursor-like protein 2 0.0275254
LPP LIM domain containing preferred translocation partner in lipoma 0.0268676
SVIL supervillin 0.0265932
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0264431
ARHGAP9 Rho GTPase activating protein 9 0.0261158
SESTD1 SEC14 and spectrin domains 1 0.0259037
DTNA dystrobrevin, alpha 0.0256672
PRELID2 PRELI domain containing 2 0.0242685
FRMD5 FERM domain containing 5 0.0229626
FLNB filamin B, beta 0.0228382
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0211207
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0208066
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0205998
PCCA propionyl CoA carboxylase, alpha polypeptide 0.019892
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0194222
RTN4 reticulon 4 0.0192186
ARL5B ADP-ribosylation factor-like 5B 0.019103
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0187089
TRIO trio Rho guanine nucleotide exchange factor 0.0184842
VMP1 vacuole membrane protein 1 0.018291
STK39 serine threonine kinase 39 0.0182889
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0181843
POTEF POTE ankyrin domain family, member F 0.0175646
FAM13A family with sequence similarity 13, member A 0.0173611
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0172963
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0171841
ANXA3 annexin A3 0.017089
LDHA lactate dehydrogenase A 0.0170232
FNDC3B fibronectin type III domain containing 3B 0.0168904
BBX bobby sox homolog (Drosophila) 0.0168897
PLXDC2 plexin domain containing 2 0.016862
KDM4C lysine (K)-specific demethylase 4C 0.0166849
PTBP3 polypyrimidine tract binding protein 3 0.0164416
MYO1B myosin IB 0.0162902
DISC1 disrupted in schizophrenia 1 0.0160906
SEC24A SEC24 family member A 0.0160376
MYH9 myosin, heavy chain 9, non-muscle 0.0160161
FHIT fragile histidine triad 0.0159766
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.01594
FKTN fukutin 0.015814
YAP1 Yes-associated protein 1 0.0155653
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0154172
PAWR PRKC, apoptosis, WT1, regulator 0.0153561
PDIA6 protein disulfide isomerase family A, member 6 0.0152419
ZZZ3 zinc finger, ZZ-type containing 3 0.0150713
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.0150025
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0148848
RAD51B RAD51 paralog B 0.0147325
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0147257
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0146989
DCBLD1 discoidin, CUB and LCCL domain containing 1 0.0145558
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0143734
RPL3 ribosomal protein L3 0.0143182
ZC3H11A zinc finger CCCH-type containing 11A 0.0142938
CCNY cyclin Y 0.014101
DIAPH1 diaphanous-related formin 1 0.0139564
JARID2 jumonji, AT rich interactive domain 2 0.0138622
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0138563
AHR aryl hydrocarbon receptor 0.0135997
IL6ST interleukin 6 signal transducer 0.0135985
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0134839
RCOR1 REST corepressor 1 0.0134702
FBXL17 F-box and leucine-rich repeat protein 17 0.0134414
FERMT2 fermitin family member 2 0.0133445
SOX5 SRY (sex determining region Y)-box 5 0.013327
RASAL2 RAS protein activator like 2 0.0132333
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0132264
AGFG1 ArfGAP with FG repeats 1 0.0132146
SFTPA2 surfactant protein A2 0.0131359
RAB3B RAB3B, member RAS oncogene family 0.012928
STK38L serine/threonine kinase 38 like 0.0129273
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0127364

decreased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.183823
TPT1 tumor protein, translationally-controlled 1 -0.15771
GPC3 glypican 3 -0.126945
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.102407
MT2A metallothionein 2A -0.0986185
RPS6 ribosomal protein S6 -0.0973914
RPS8 ribosomal protein S8 -0.0923446
RPL37A ribosomal protein L37a -0.0860674
APOB apolipoprotein B -0.0773319
RPS19 ribosomal protein S19 -0.0750113
SDC4 syndecan 4 -0.0711544
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0689731
RPS24 ribosomal protein S24 -0.0689477
FTL ferritin, light polypeptide -0.0667902
RPL35A ribosomal protein L35a -0.0641412
RPL11 ribosomal protein L11 -0.0637271
NKD1 naked cuticle homolog 1 (Drosophila) -0.0617669
RPS12 ribosomal protein S12 -0.0606638
RPL31 ribosomal protein L31 -0.0596258
TM4SF1 transmembrane 4 L six family member 1 -0.0584882
RPS3 ribosomal protein S3 -0.0568591
RPL34 ribosomal protein L34 -0.0567398
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0566003
RPS27A ribosomal protein S27a -0.0554982
GNAS GNAS complex locus -0.0546766
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0539663
RPLP1 ribosomal protein, large, P1 -0.0538218
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0512508
NAP1L1 nucleosome assembly protein 1-like 1 -0.050947
PEG3 paternally expressed 3 -0.0507097
RPL5 ribosomal protein L5 -0.0493695
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0485547
TMSB10 thymosin beta 10 -0.0472102
LOC112694756 uncharaterized LOC112694756 -0.0462151
RACK1 receptor for activated C kinase 1 -0.0446035
RPL26 ribosomal protein L26 -0.0442841
RPL12 ribosomal protein L12 -0.0434087
RPL9 ribosomal protein L9 -0.0424757
KIF21A kinesin family member 21A -0.0424541
RPS21 ribosomal protein S21 -0.0423647
RPL19 ribosomal protein L19 -0.0420283
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0416691
RPL37 ribosomal protein L37 -0.0411834
APOA2 apolipoprotein A-II -0.041094
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0407871
IGF1R insulin-like growth factor 1 receptor -0.0404409
RPL23 ribosomal protein L23 -0.0398289
APOE apolipoprotein E -0.039519
GDF15 growth differentiation factor 15 -0.0381982
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0380304
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0367008
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0363766
AMBP alpha-1-microglobulin/bikunin precursor -0.0362074
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0357841
RPS13 ribosomal protein S13 -0.0354789
IER3 immediate early response 3 -0.0350521
TRIM26 tripartite motif containing 26 -0.0341839
C3 complement component 3 -0.0337568
DDIT4 DNA-damage-inducible transcript 4 -0.0337332
RPL7 ribosomal protein L7 -0.0336174
RPLP2 ribosomal protein, large, P2 -0.0336167
RPLP0 ribosomal protein, large, P0 -0.0324935
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0324624
CPE carboxypeptidase E -0.0319379
PRRC2C proline-rich coiled-coil 2C -0.0318647
RBM25 RNA binding motif protein 25 -0.0314902
RPL13A ribosomal protein L13a -0.0309448
ELL2 elongation factor, RNA polymerase II, 2 -0.0304447
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0303277
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0298859
GCC2 GRIP and coiled-coil domain containing 2 -0.0298553
B2M beta-2-microglobulin -0.0297215
RERE arginine-glutamic acid dipeptide (RE) repeats -0.02952
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0290722
RPS25 ribosomal protein S25 -0.0289324
RBM39 RNA binding motif protein 39 -0.0285124
SLC38A1 solute carrier family 38, member 1 -0.0284015
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0280363
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0280326
RRBP1 ribosome binding protein 1 -0.0278047
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0278005
RPS29 ribosomal protein S29 -0.0277258
DSCAM Down syndrome cell adhesion molecule -0.026984
RPL27A ribosomal protein L27a -0.0269613
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.026958
PTMA prothymosin, alpha -0.0267344
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0265024
PTPRF protein tyrosine phosphatase, receptor type, F -0.0263352
RPS16 ribosomal protein S16 -0.0263288
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.026284
APOA1 apolipoprotein A-I -0.0259871
RNF213 ring finger protein 213 -0.0258637
LCN2 lipocalin 2 -0.0257633
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0255944
RPS23 ribosomal protein S23 -0.0254757
NCOA7 nuclear receptor coactivator 7 -0.0254009
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0253745
WDR45B WD repeat domain 45B -0.0253292
H1-0 H1.0 linker histone -0.0249879
RAD21 RAD21 homolog (S. pombe) -0.0248762