(S)-Crizotinib_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (S)-Crizotinib perturbation in LS 180 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the (S)-Crizotinib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.142763
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.126035
NPSR1 neuropeptide S receptor 1 0.0840959
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0663586
DSPP dentin sialophosphoprotein 0.0629137
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0605961
EZR ezrin 0.060113
FAM13A family with sequence similarity 13, member A 0.0600181
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0528693
INSIG1 insulin induced gene 1 0.0516479
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0515304
CEMIP cell migration inducing protein, hyaluronan binding 0.0506573
LDHA lactate dehydrogenase A 0.0502666
FAT1 FAT atypical cadherin 1 0.0497728
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0485294
PRELID2 PRELI domain containing 2 0.0484229
ZNF292 zinc finger protein 292 0.0474943
FNDC3B fibronectin type III domain containing 3B 0.0468153
TXNIP thioredoxin interacting protein 0.0453708
NDRG1 N-myc downstream regulated 1 0.0440915
CCNY cyclin Y 0.0433523
ITGA6 integrin, alpha 6 0.0426975
FLNB filamin B, beta 0.0423877
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0423635
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0422831
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0368884
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0363168
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0338659
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0338512
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0329825
PTPRR protein tyrosine phosphatase, receptor type, R 0.0322001
EREG epiregulin 0.0320987
ESYT2 extended synaptotagmin-like protein 2 0.0308768
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0295328
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.0291085
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0289195
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0283332
CALB1 calbindin 1, 28kDa 0.0280869
GPHN gephyrin 0.0276528
FDPS farnesyl diphosphate synthase 0.0275731
MYH9 myosin, heavy chain 9, non-muscle 0.0273562
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0264501
AHNAK AHNAK nucleoprotein 0.0260033
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0254348
RREB1 ras responsive element binding protein 1 0.0253864
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0251577
KDM7A lysine (K)-specific demethylase 7A 0.0249979
ARHGAP12 Rho GTPase activating protein 12 0.0249533
LRRC1 leucine rich repeat containing 1 0.0247923
ITPRID2 ITPR interacting domain containing 2 0.0246076
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0245812
ERRFI1 ERBB receptor feedback inhibitor 1 0.0244602
TRIO trio Rho guanine nucleotide exchange factor 0.0239445
LMO7 LIM domain 7 0.0238412
PPARG peroxisome proliferator-activated receptor gamma 0.0237437
TNIK TRAF2 and NCK interacting kinase 0.0235327
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0231226
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 0.0225189
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0224311
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0222467
MSMO1 methylsterol monooxygenase 1 0.0222313
UBA6 ubiquitin-like modifier activating enzyme 6 0.0221991
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0221724
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0221484
ADIPOR2 adiponectin receptor 2 0.0221027
LIMCH1 LIM and calponin homology domains 1 0.0217996
FNBP1L formin binding protein 1-like 0.0217392
LPIN1 lipin 1 0.0216963
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.021577
KDM4C lysine (K)-specific demethylase 4C 0.0214602
EHF ets homologous factor 0.0214481
VEGFA vascular endothelial growth factor A 0.0213447
ARHGAP26 Rho GTPase activating protein 26 0.0213441
CDC42SE2 CDC42 small effector 2 0.0209972
RTN4 reticulon 4 0.0208815
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0206457
ZFAND3 zinc finger, AN1-type domain 3 0.0205445
PTEN phosphatase and tensin homolog 0.0205178
DENND1A DENN/MADD domain containing 1A 0.020374
BZW1 basic leucine zipper and W2 domains 1 0.0201689
ADD3 adducin 3 (gamma) 0.0201043
AKAP13 A kinase (PRKA) anchor protein 13 0.0200692
MED13L mediator complex subunit 13-like 0.0200085
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0199319
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0197148
RAD51B RAD51 paralog B 0.0196853
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0196797
CALR calreticulin 0.0196082
PARD3 par-3 family cell polarity regulator 0.0195905
PDIA3 protein disulfide isomerase family A, member 3 0.0195446
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0195409
SREBF2 sterol regulatory element binding transcription factor 2 0.0194317
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0192893
INSIG2 insulin induced gene 2 0.0192263
SERINC5 serine incorporator 5 0.0191529
TMEM135 transmembrane protein 135 0.0189261
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0187916
OSBPL9 oxysterol binding protein-like 9 0.0187099
TM9SF3 transmembrane 9 superfamily member 3 0.018467
IQGAP1 IQ motif containing GTPase activating protein 1 0.0183568

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.232487
TMSB10 thymosin beta 10 -0.166999
RPS6 ribosomal protein S6 -0.104679
TPT1 tumor protein, translationally-controlled 1 -0.0914285
RPL35A ribosomal protein L35a -0.082746
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0793977
RPS19 ribosomal protein S19 -0.0742289
RPS8 ribosomal protein S8 -0.0725374
RPLP1 ribosomal protein, large, P1 -0.0711059
RPL34 ribosomal protein L34 -0.0633839
RPS12 ribosomal protein S12 -0.0586311
S100P S100 calcium binding protein P -0.0549403
RPL23 ribosomal protein L23 -0.0543026
RPLP2 ribosomal protein, large, P2 -0.0538178
RPL37A ribosomal protein L37a -0.0515107
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0506845
FTL ferritin, light polypeptide -0.0503449
RPL5 ribosomal protein L5 -0.0493201
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0488248
RPL9 ribosomal protein L9 -0.0486613
RPL19 ribosomal protein L19 -0.0484957
ACTG1 actin gamma 1 -0.0482243
RPL12 ribosomal protein L12 -0.0478088
RPS3 ribosomal protein S3 -0.0466378
EIF1 eukaryotic translation initiation factor 1 -0.0448799
RPL26 ribosomal protein L26 -0.0444609
RPL31 ribosomal protein L31 -0.0441887
RPS24 ribosomal protein S24 -0.0407798
RPL36 ribosomal protein L36 -0.040373
ISG15 ISG15 ubiquitin-like modifier -0.0392228
S100A6 S100 calcium binding protein A6 -0.0370049
RPS23 ribosomal protein S23 -0.0367358
RPS25 ribosomal protein S25 -0.0356702
AREG amphiregulin -0.0346044
RPS13 ribosomal protein S13 -0.0344902
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0340889
RPL7A ribosomal protein L7a -0.0331178
RPS27A ribosomal protein S27a -0.032703
RPS29 ribosomal protein S29 -0.032304
RPL37 ribosomal protein L37 -0.0321216
RBM25 RNA binding motif protein 25 -0.0320075
RPL11 ribosomal protein L11 -0.0319307
RPS14 ribosomal protein S14 -0.030998
RPL27A ribosomal protein L27a -0.0308094
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0304133
RPLP0 ribosomal protein, large, P0 -0.0301991
RPS21 ribosomal protein S21 -0.0301201
S100A9 S100 calcium binding protein A9 -0.0300474
HMGA1 high mobility group AT-hook 1 -0.0299789
RPL36A ribosomal protein L36a -0.0294986
RPL18 ribosomal protein L18 -0.0291484
MT2A metallothionein 2A -0.0286592
RPS27 ribosomal protein S27 -0.0284448
RPS11 ribosomal protein S11 -0.0281584
RPS17 ribosomal protein S17 -0.0278569
RPL8 ribosomal protein L8 -0.026749
RPL32 ribosomal protein L32 -0.0264676
GDF15 growth differentiation factor 15 -0.0254329
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0254307
IER3 immediate early response 3 -0.0251829
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0248447
RPL27 ribosomal protein L27 -0.0246625
PNISR PNN-interacting serine/arginine-rich protein -0.0242639
ATF4 activating transcription factor 4 -0.0241196
RPL30 ribosomal protein L30 -0.0238624
RPL28 ribosomal protein L28 -0.0234099
RPS16 ribosomal protein S16 -0.0233111
RPL35 ribosomal protein L35 -0.0229694
SERF2 small EDRK-rich factor 2 -0.0221509
MYL12B myosin, light chain 12B, regulatory -0.0215713
PRRC2C proline-rich coiled-coil 2C -0.0215295
TFF1 trefoil factor 1 -0.0212956
RPL7 ribosomal protein L7 -0.0211863
RPS10 ribosomal protein S10 -0.0211436
B2M beta-2-microglobulin -0.0204878
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.0202913
RPS5 ribosomal protein S5 -0.0201144
RPL10A ribosomal protein L10a -0.0199228
RACK1 receptor for activated C kinase 1 -0.0198924
TFF3 trefoil factor 3 (intestinal) -0.0193784
EIF5B eukaryotic translation initiation factor 5B -0.0193054
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0192646
LMNA lamin A/C -0.0192033
PIGR polymeric immunoglobulin receptor -0.0191529
RPL38 ribosomal protein L38 -0.0190284
MT1X metallothionein 1X -0.0185979
CCND1 cyclin D1 -0.0183621
RPL36AL ribosomal protein L36a-like -0.0182491
RPL15 ribosomal protein L15 -0.0182257
CLDN7 claudin 7 -0.018114
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0180812
RPL13A ribosomal protein L13a -0.0179889
MYO1E myosin IE -0.0178446
RPS2 ribosomal protein S2 -0.0177049
HMGB1 high mobility group box 1 -0.0176018
S100A10 S100 calcium binding protein A10 -0.0175072
GUK1 guanylate kinase 1 -0.017377
RPS20 ribosomal protein S20 -0.0172791
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0171779
GADD45A growth arrest and DNA-damage-inducible, alpha -0.0169504