| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | (S)-Crizotinib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the (S)-Crizotinib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DST | dystonin | 0.0544346 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.045087 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0403927 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0353257 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0285712 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0251843 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0234702 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0199489 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.019062 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0180938 |
| ATP13A3 | ATPase type 13A3 | 0.017716 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0176395 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0174673 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0174317 |
| EREG | epiregulin | 0.0166327 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0161762 |
| WDR43 | WD repeat domain 43 | 0.0159501 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0146761 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0141284 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0137136 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0137071 |
| EHBP1 | EH domain binding protein 1 | 0.0136681 |
| EZR | ezrin | 0.0133973 |
| LRRC49 | leucine rich repeat containing 49 | 0.0132847 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0132779 |
| TNS3 | tensin 3 | 0.0131584 |
| HDAC9 | histone deacetylase 9 | 0.0130604 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0128315 |
| SERINC1 | serine incorporator 1 | 0.0126395 |
| ACACA | acetyl-CoA carboxylase alpha | 0.0125542 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0123322 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0122246 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0120199 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.011916 |
| EFNA5 | ephrin-A5 | 0.0116985 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0115253 |
| RAD51B | RAD51 paralog B | 0.011371 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0112502 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0112479 |
| DOCK11 | dedicator of cytokinesis 11 | 0.0112407 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | 0.0111776 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | 0.0111382 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.011085 |
| ETNK1 | ethanolamine kinase 1 | 0.0110598 |
| FDPS | farnesyl diphosphate synthase | 0.0110313 |
| PDE10A | phosphodiesterase 10A | 0.0109774 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0108994 |
| QKI | QKI, KH domain containing, RNA binding | 0.0105544 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0104563 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0103525 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.0103487 |
| PRELID2 | PRELI domain containing 2 | 0.0101842 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0100509 |
| CSMD3 | CUB and Sushi multiple domains 3 | 0.00994711 |
| ANKRD11 | ankyrin repeat domain 11 | 0.00962068 |
| DNER | delta/notch-like EGF repeat containing | 0.00946116 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.00940626 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.00937414 |
| TXNRD1 | thioredoxin reductase 1 | 0.00928054 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.00927526 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.00926788 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.00921851 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.00913277 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.00909394 |
| TMEM41B | transmembrane protein 41B | 0.00904783 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 0.0089697 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.00890504 |
| NAV2 | neuron navigator 2 | 0.00885892 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.00881222 |
| CDC73 | cell division cycle 73 | 0.00878954 |
| HSPA8 | heat shock 70kDa protein 8 | 0.00874722 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0086275 |
| SQSTM1 | sequestosome 1 | 0.00862661 |
| TP63 | tumor protein p63 | 0.00857879 |
| MEMO1 | mediator of cell motility 1 | 0.00854329 |
| RAI1 | retinoic acid induced 1 | 0.00850787 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.00850672 |
| DENND1A | DENN/MADD domain containing 1A | 0.00846728 |
| RCOR1 | REST corepressor 1 | 0.0084206 |
| RUNX1 | runt-related transcription factor 1 | 0.0083202 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0082277 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.00821351 |
| ADIPOR2 | adiponectin receptor 2 | 0.00814368 |
| ZNF292 | zinc finger protein 292 | 0.00811072 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.00808402 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.00804217 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.00803686 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.00802184 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0080111 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.00800744 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.00796949 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.00759827 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.007597 |
| RPS7 | ribosomal protein S7 | 0.0075632 |
| KPNA1 | karyopherin alpha 1 (importin alpha 5) | 0.00755406 |
| SCAF4 | SR-related CTD-associated factor 4 | 0.0074955 |
| MAT2A | methionine adenosyltransferase II, alpha | 0.00740628 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.00732293 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.00732086 |
| RHOA | ras homolog family member A | 0.00731973 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.364617 |
| VIM | vimentin | -0.245882 |
| PTMA | prothymosin, alpha | -0.148734 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.147798 |
| MT2A | metallothionein 2A | -0.130998 |
| TMSB10 | thymosin beta 10 | -0.0935518 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0730339 |
| FTL | ferritin, light polypeptide | -0.0616083 |
| TXNIP | thioredoxin interacting protein | -0.0604132 |
| RPL35A | ribosomal protein L35a | -0.050959 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0503424 |
| HMGA1 | high mobility group AT-hook 1 | -0.0483781 |
| RPS6 | ribosomal protein S6 | -0.0480754 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0472157 |
| ACTG1 | actin gamma 1 | -0.0456129 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0439732 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0366542 |
| MT1X | metallothionein 1X | -0.0365049 |
| RPS8 | ribosomal protein S8 | -0.0359926 |
| CANX | calnexin | -0.0359701 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0352302 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | -0.0349319 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0348935 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0343021 |
| POTEF | POTE ankyrin domain family, member F | -0.0341446 |
| HLA-B | major histocompatibility complex, class I, B | -0.0340632 |
| MT1E | metallothionein 1E | -0.033115 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0305711 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0296763 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0294465 |
| PFN1 | profilin 1 | -0.029315 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.028657 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0281471 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0280048 |
| EGR1 | early growth response 1 | -0.0275021 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0272766 |
| CD44 | CD44 molecule (Indian blood group) | -0.0268167 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.026025 |
| CALR | calreticulin | -0.0259637 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0257046 |
| RPL8 | ribosomal protein L8 | -0.0256548 |
| RPL12 | ribosomal protein L12 | -0.0256044 |
| UBC | ubiquitin C | -0.0254429 |
| RPS19 | ribosomal protein S19 | -0.0253065 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0251974 |
| S100A9 | S100 calcium binding protein A9 | -0.0251243 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0250107 |
| S100A10 | S100 calcium binding protein A10 | -0.02455 |
| RPL28 | ribosomal protein L28 | -0.0242064 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0236462 |
| RPS23 | ribosomal protein S23 | -0.0235286 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0234752 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.023363 |
| SRGN | serglycin | -0.0229835 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0219944 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0218428 |
| NDRG1 | N-myc downstream regulated 1 | -0.0215497 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0213914 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0211671 |
| PKM | pyruvate kinase, muscle | -0.0203187 |
| RPLP1 | ribosomal protein, large, P1 | -0.0202174 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0201007 |
| WDR45B | WD repeat domain 45B | -0.0198296 |
| RPL19 | ribosomal protein L19 | -0.0195179 |
| RPL5 | ribosomal protein L5 | -0.0195134 |
| RPL36A | ribosomal protein L36a | -0.0193477 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0189095 |
| DEK | DEK proto-oncogene | -0.0186576 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0185901 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0185167 |
| RPL31 | ribosomal protein L31 | -0.0179765 |
| RPLP2 | ribosomal protein, large, P2 | -0.0178363 |
| RPS13 | ribosomal protein S13 | -0.0177727 |
| RPL36 | ribosomal protein L36 | -0.017743 |
| FBXO11 | F-box protein 11 | -0.017669 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.017558 |
| SEPTIN7 | septin 7 | -0.0170019 |
| MYADM | myeloid-associated differentiation marker | -0.0168467 |
| ADAR | adenosine deaminase, RNA-specific | -0.0167529 |
| RPL34 | ribosomal protein L34 | -0.0166785 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0166662 |
| GLG1 | golgi glycoprotein 1 | -0.0164539 |
| WASF2 | WAS protein family, member 2 | -0.0164371 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0163773 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0163732 |
| TPI1 | triosephosphate isomerase 1 | -0.0163309 |
| RPS29 | ribosomal protein S29 | -0.0162581 |
| RPS10 | ribosomal protein S10 | -0.0159561 |
| RPS14 | ribosomal protein S14 | -0.0154837 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0154627 |
| B2M | beta-2-microglobulin | -0.0154305 |
| JMJD1C | jumonji domain containing 1C | -0.015406 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0154004 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0153948 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0151813 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0148163 |
| RPL26 | ribosomal protein L26 | -0.0147924 |
| GART | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase | -0.0146031 |
| RPS25 | ribosomal protein S25 | -0.0145979 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0144599 |
