| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | (S)-Crizotinib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the (S)-Crizotinib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.211661 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0816521 |
| FAM13A | family with sequence similarity 13, member A | 0.0665428 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0519729 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0427907 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.039769 |
| PYGL | phosphorylase, glycogen, liver | 0.0385483 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0343066 |
| NGLY1 | N-glycanase 1 | 0.0330542 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0322157 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0308934 |
| LDHA | lactate dehydrogenase A | 0.0302315 |
| CES1 | carboxylesterase 1 | 0.0285602 |
| NDRG1 | N-myc downstream regulated 1 | 0.027492 |
| GOLGB1 | golgin B1 | 0.0274715 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0261127 |
| HYOU1 | hypoxia up-regulated 1 | 0.0259889 |
| MKI67 | marker of proliferation Ki-67 | 0.0249008 |
| HELZ | helicase with zinc finger | 0.0244876 |
| COPA | coatomer protein complex, subunit alpha | 0.0238186 |
| PCBP2 | poly(rC) binding protein 2 | 0.0236669 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0235592 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0226328 |
| TMF1 | TATA element modulatory factor 1 | 0.0221672 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0220371 |
| ARRDC3 | arrestin domain containing 3 | 0.0220269 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0218637 |
| ZNF292 | zinc finger protein 292 | 0.0217252 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.0204219 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.020005 |
| MORF4L2 | mortality factor 4 like 2 | 0.0197968 |
| MSN | moesin | 0.0195293 |
| SEC24D | SEC24 family member D | 0.0194891 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0190557 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0190455 |
| ZNF638 | zinc finger protein 638 | 0.0190152 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0182953 |
| SCFD1 | sec1 family domain containing 1 | 0.017945 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0177811 |
| TMEM39A | transmembrane protein 39A | 0.017505 |
| GOLGA4 | golgin A4 | 0.0175023 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0174628 |
| TFG | TRK-fused gene | 0.0174218 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0173724 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.017259 |
| PTEN | phosphatase and tensin homolog | 0.0166008 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0165186 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0163019 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.016132 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.016069 |
| SUCO | SUN domain containing ossification factor | 0.016025 |
| C1D | C1D nuclear receptor corepressor | 0.0159705 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0159418 |
| TBC1D22A | TBC1 domain family, member 22A | 0.015783 |
| WDR26 | WD repeat domain 26 | 0.015772 |
| TMEM45B | transmembrane protein 45B | 0.0155869 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0155328 |
| BLTP1 | bridge-like lipid transfer protein family member 1 | 0.0155262 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0154482 |
| DTNA | dystrobrevin, alpha | 0.0154433 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0151985 |
| COG6 | component of oligomeric golgi complex 6 | 0.0149972 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0149548 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0149003 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.014807 |
| TMCO3 | transmembrane and coiled-coil domains 3 | 0.0146028 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0141465 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0140752 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0139779 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0139536 |
| RARS1 | arginyl-tRNA synthetase 1 | 0.0137331 |
| FRY | furry homolog (Drosophila) | 0.0137178 |
| CENPF | centromere protein F, 350/400kDa | 0.0136755 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0135831 |
| TPM3 | tropomyosin 3 | 0.0135299 |
| FAM110C | family with sequence similarity 110, member C | 0.0132895 |
| ZBTB1 | zinc finger and BTB domain containing 1 | 0.0132616 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0132461 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0132148 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0131739 |
| USP47 | ubiquitin specific peptidase 47 | 0.0131503 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0128523 |
| TXNDC11 | thioredoxin domain containing 11 | 0.0127337 |
| N4BP2 | NEDD4 binding protein 2 | 0.0127293 |
| PAPOLA | poly(A) polymerase alpha | 0.0126869 |
| NBAS | neuroblastoma amplified sequence | 0.0126639 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0125929 |
| ANO6 | anoctamin 6 | 0.0125652 |
| GPATCH2L | G patch domain containing 2-like | 0.0124586 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0123953 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | 0.0123825 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.01238 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.0123327 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0123071 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0122854 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0122224 |
| ATP11B | ATPase, class VI, type 11B | 0.0118623 |
| DYNC2I1 | dynein 2 intermediate chain 1 | 0.0118382 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0118015 |
| PRRC1 | proline-rich coiled-coil 1 | 0.0117359 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.177603 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.15973 |
| TXNRD1 | thioredoxin reductase 1 | -0.11077 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0950638 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0799555 |
| FTL | ferritin, light polypeptide | -0.0783101 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0737444 |
| RPS3 | ribosomal protein S3 | -0.0692462 |
| RPLP1 | ribosomal protein, large, P1 | -0.0665831 |
| MT2A | metallothionein 2A | -0.064618 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0632173 |
| RPL35A | ribosomal protein L35a | -0.0627343 |
| ANXA2 | annexin A2 | -0.0626485 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0624069 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0581789 |
| PTMA | prothymosin, alpha | -0.0563032 |
| B2M | beta-2-microglobulin | -0.0536787 |
| ACTG1 | actin gamma 1 | -0.053054 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0527147 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0521272 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0517493 |
| S100A10 | S100 calcium binding protein A10 | -0.0517075 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0505056 |
| LMO7 | LIM domain 7 | -0.048892 |
| LAMC2 | laminin, gamma 2 | -0.0482647 |
| CST3 | cystatin C | -0.0475301 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0472506 |
| ASPH | aspartate beta-hydroxylase | -0.0447781 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.044626 |
| RNF213 | ring finger protein 213 | -0.0445313 |
| RPS25 | ribosomal protein S25 | -0.0441855 |
| RPS24 | ribosomal protein S24 | -0.0413922 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0410783 |
| KRT7 | keratin 7, type II | -0.0410731 |
| RPL37A | ribosomal protein L37a | -0.0409164 |
| RPL31 | ribosomal protein L31 | -0.0400812 |
| EGR1 | early growth response 1 | -0.0398315 |
| RPL34 | ribosomal protein L34 | -0.0396454 |
| SEC61G | Sec61 gamma subunit | -0.039432 |
| RPS8 | ribosomal protein S8 | -0.038108 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0378207 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0369799 |
| CCND1 | cyclin D1 | -0.0366243 |
| EFNA5 | ephrin-A5 | -0.0339209 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.033817 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0337631 |
| AHNAK | AHNAK nucleoprotein | -0.0328968 |
| RPS27A | ribosomal protein S27a | -0.0323401 |
| HLA-B | major histocompatibility complex, class I, B | -0.0322072 |
| PKM | pyruvate kinase, muscle | -0.0317298 |
| OSMR | oncostatin M receptor | -0.0316744 |
| RAB10 | RAB10, member RAS oncogene family | -0.0314735 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.030898 |
| RPS12 | ribosomal protein S12 | -0.0308263 |
| RPS6 | ribosomal protein S6 | -0.0303114 |
| RPS19 | ribosomal protein S19 | -0.0299851 |
| PGK1 | phosphoglycerate kinase 1 | -0.0291828 |
| KRT8 | keratin 8, type II | -0.0291098 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0290806 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0287894 |
| RPS23 | ribosomal protein S23 | -0.0287387 |
| NTN4 | netrin 4 | -0.0285376 |
| H1-0 | H1.0 linker histone | -0.0283153 |
| IER3 | immediate early response 3 | -0.0281147 |
| RPL19 | ribosomal protein L19 | -0.0279766 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0273502 |
| S100A9 | S100 calcium binding protein A9 | -0.0271178 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0269946 |
| RPS29 | ribosomal protein S29 | -0.0268708 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0263444 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0262398 |
| RPS21 | ribosomal protein S21 | -0.0261827 |
| RPLP2 | ribosomal protein, large, P2 | -0.0259947 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0255409 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0255055 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0249826 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0248795 |
| RPL30 | ribosomal protein L30 | -0.0248099 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0247506 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.024713 |
| SDC4 | syndecan 4 | -0.0246631 |
| KRT18 | keratin 18, type I | -0.0246196 |
| MAP7 | microtubule-associated protein 7 | -0.0242202 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0239476 |
| RPL12 | ribosomal protein L12 | -0.0238043 |
| RPS27 | ribosomal protein S27 | -0.0233003 |
| RPL37 | ribosomal protein L37 | -0.0231931 |
| S100A11 | S100 calcium binding protein A11 | -0.0226783 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0226196 |
| RPL11 | ribosomal protein L11 | -0.0224352 |
| RPL36 | ribosomal protein L36 | -0.0223973 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0223906 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0222836 |
| S100A6 | S100 calcium binding protein A6 | -0.0222801 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0221789 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0221683 |
| RPL8 | ribosomal protein L8 | -0.0221185 |
| RPS17 | ribosomal protein S17 | -0.0219908 |
| MGST1 | microsomal glutathione S-transferase 1 | -0.0219539 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0219166 |
