(S)-Crizotinib_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description (S)-Crizotinib perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the (S)-Crizotinib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.290036
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.132542
PCBP2 poly(rC) binding protein 2 0.119244
FNDC3B fibronectin type III domain containing 3B 0.118274
FAM13A family with sequence similarity 13, member A 0.0992248
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0953592
GPC6 glypican 6 0.0900634
AKAP12 A kinase (PRKA) anchor protein 12 0.0853466
ZNF292 zinc finger protein 292 0.0843132
NAV2 neuron navigator 2 0.0834703
GOLGA4 golgin A4 0.0746384
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.073761
PRELID2 PRELI domain containing 2 0.0700135
ELL2 elongation factor, RNA polymerase II, 2 0.0688402
SMAD3 SMAD family member 3 0.0668581
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.063591
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0616496
PIAS2 protein inhibitor of activated STAT, 2 0.0598897
DLG1 discs, large homolog 1 (Drosophila) 0.058875
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0569419
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0566411
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0565469
TRIO trio Rho guanine nucleotide exchange factor 0.0552781
ESYT2 extended synaptotagmin-like protein 2 0.054018
HELZ helicase with zinc finger 0.0520725
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0509363
ATP13A3 ATPase type 13A3 0.050936
NBAS neuroblastoma amplified sequence 0.0508059
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0483946
ADD3 adducin 3 (gamma) 0.0480587
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0467836
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0457533
SEC23A Sec23 homolog A (S. cerevisiae) 0.0447335
RICTOR RPTOR independent companion of MTOR, complex 2 0.0433874
LDHA lactate dehydrogenase A 0.0422637
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0420468
FBXL13 F-box and leucine-rich repeat protein 13 0.0419805
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0419347
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0415434
PTPRR protein tyrosine phosphatase, receptor type, R 0.0412939
SOD2 superoxide dismutase 2, mitochondrial 0.041134
KMT2C lysine (K)-specific methyltransferase 2C 0.0411014
MEF2A myocyte enhancer factor 2A 0.0410254
PDIA3 protein disulfide isomerase family A, member 3 0.0408069
UBA6 ubiquitin-like modifier activating enzyme 6 0.0393602
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0393464
FLNB filamin B, beta 0.0389371
APLP2 amyloid beta (A4) precursor-like protein 2 0.0385191
CHD1L chromodomain helicase DNA binding protein 1-like 0.0381457
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0379697
AHR aryl hydrocarbon receptor 0.0372051
HAS2 hyaluronan synthase 2 0.0368808
USP3 ubiquitin specific peptidase 3 0.0368478
PLIN2 perilipin 2 0.0367944
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0363987
ASPH aspartate beta-hydroxylase 0.0361314
RUNX1 runt-related transcription factor 1 0.0358645
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0357326
RARB retinoic acid receptor, beta 0.0357041
SLTM SAFB-like, transcription modulator 0.0355152
ANXA1 annexin A1 0.0354101
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0351357
KDM2A lysine (K)-specific demethylase 2A 0.035103
SUCO SUN domain containing ossification factor 0.0347199
MYOF myoferlin 0.034231
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.033684
MSN moesin 0.0333892
NDRG1 N-myc downstream regulated 1 0.0330716
RTN4 reticulon 4 0.0325565
RAB8B RAB8B, member RAS oncogene family 0.0325126
RAD51B RAD51 paralog B 0.0324385
USP34 ubiquitin specific peptidase 34 0.0321902
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0319384
BBX bobby sox homolog (Drosophila) 0.0316165
ENO1 enolase 1, (alpha) 0.0311104
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0305711
RAB6A RAB6A, member RAS oncogene family 0.0305549
FBXO32 F-box protein 32 0.0305167
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0303889
PTK2 protein tyrosine kinase 2 0.0301731
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0301495
RIOK3 RIO kinase 3 0.0300931
LIFR leukemia inhibitory factor receptor alpha 0.0293138
CD109 CD109 molecule 0.0293132
COPA coatomer protein complex, subunit alpha 0.0290447
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0288581
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0288052
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0287938
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0284886
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0281931
PDIA6 protein disulfide isomerase family A, member 6 0.0280125
GRB10 growth factor receptor-bound protein 10 0.0279384
XPO1 exportin 1 0.0277261
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0273858
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0271951
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.027167
SPAG9 sperm associated antigen 9 0.0271353
EEF2 eukaryotic translation elongation factor 2 0.0271306
INSIG2 insulin induced gene 2 0.0269695
CDCP1 CUB domain containing protein 1 0.0268147

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.108358
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.103114
GLCCI1 glucocorticoid induced 1 -0.0975762
HMGA2 high mobility group AT-hook 2 -0.0760502
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0740817
STC1 stanniocalcin 1 -0.0694324
VIM vimentin -0.0646948
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0592532
NTN4 netrin 4 -0.0564847
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0544932
EXT1 exostosin glycosyltransferase 1 -0.0537318
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0535929
FAM20C family with sequence similarity 20, member C -0.0506162
AADAC arylacetamide deacetylase -0.0495769
IER3 immediate early response 3 -0.0477262
NRG1 neuregulin 1 -0.0462062
RPL35A ribosomal protein L35a -0.0446024
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.043798
RPS19 ribosomal protein S19 -0.0437918
OSMR oncostatin M receptor -0.0417879
VRK2 vaccinia related kinase 2 -0.0417771
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.04166
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0410637
ZNF804A zinc finger protein 804A -0.039936
MT2A metallothionein 2A -0.0391598
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0389428
KYNU kynureninase -0.0384015
EGR1 early growth response 1 -0.0354271
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0352962
LOX lysyl oxidase -0.0347933
FN1 fibronectin 1 -0.033209
NLK nemo-like kinase -0.0331332
RPLP1 ribosomal protein, large, P1 -0.0324712
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0321089
FBN1 fibrillin 1 -0.0310959
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0310298
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0308299
GLIS3 GLIS family zinc finger 3 -0.0307217
RPL31 ribosomal protein L31 -0.0307205
RPS8 ribosomal protein S8 -0.0307109
RPLP2 ribosomal protein, large, P2 -0.0304369
HLA-B major histocompatibility complex, class I, B -0.0304309
TPT1 tumor protein, translationally-controlled 1 -0.0301251
RPL34 ribosomal protein L34 -0.029895
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0294976
NCOA7 nuclear receptor coactivator 7 -0.0294932
PTMA prothymosin, alpha -0.0291472
DAAM1 dishevelled associated activator of morphogenesis 1 -0.0290245
CDH13 cadherin 13 -0.0289334
RPL37A ribosomal protein L37a -0.0289256
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0288597
WLS wntless Wnt ligand secretion mediator -0.0284649
INTS6 integrator complex subunit 6 -0.0284234
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0281022
DPYD dihydropyrimidine dehydrogenase -0.0279934
RIGI RNA sensor RIG-I -0.0275326
PID1 phosphotyrosine interaction domain containing 1 -0.0272693
RPS29 ribosomal protein S29 -0.0270139
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0266041
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0265628
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.026471
CLMP CXADR-like membrane protein -0.0258242
RPL32 ribosomal protein L32 -0.025489
BPTF bromodomain PHD finger transcription factor -0.0251995
RPL19 ribosomal protein L19 -0.0249647
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0240931
SEPTIN9 septin 9 -0.0239622
CLIC4 chloride intracellular channel 4 -0.0238337
COL12A1 collagen, type XII, alpha 1 -0.0234137
AVIL advillin -0.0233617
HDAC4 histone deacetylase 4 -0.0233484
EIF1 eukaryotic translation initiation factor 1 -0.0232718
RPS12 ribosomal protein S12 -0.0232201
S100A6 S100 calcium binding protein A6 -0.0231648
TM4SF1 transmembrane 4 L six family member 1 -0.0231149
FRMD4A FERM domain containing 4A -0.0228692
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0224837
RPL9 ribosomal protein L9 -0.0224234
ATG7 autophagy related 7 -0.022263
ACTG1 actin gamma 1 -0.0222063
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0221685
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0221251
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0220227
NUMB numb homolog (Drosophila) -0.0220081
PSEN1 presenilin 1 -0.0218984
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0217955
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0215575
MTSS1 metastasis suppressor 1 -0.0215425
CCDC88A coiled-coil domain containing 88A -0.0215153
TRPS1 trichorhinophalangeal syndrome I -0.0213712
CUX1 cut-like homeobox 1 -0.0212202
PCNX4 pecanex 4 -0.0211867
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0209853
RSU1 Ras suppressor protein 1 -0.020916
DNER delta/notch-like EGF repeat containing -0.020883
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0208512
FNBP1 formin binding protein 1 -0.0208145
TFPI2 tissue factor pathway inhibitor 2 -0.0207293
TNS3 tensin 3 -0.0206716
RPS21 ribosomal protein S21 -0.0204564